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公开(公告)号:US20080163386A1
公开(公告)日:2008-07-03
申请号:US11627977
申请日:2007-01-28
申请人: Felix D. Karim , Linda Nolan Keyes , Gregory D. Plowman , Michael Martin Ollmann , Mark E. Maxwell , Thierry Tidiane Diagana
发明人: Felix D. Karim , Linda Nolan Keyes , Gregory D. Plowman , Michael Martin Ollmann , Mark E. Maxwell , Thierry Tidiane Diagana
IPC分类号: G01N33/483 , G01N33/50 , C12N5/06 , C12Q1/02
CPC分类号: C12Q1/6883 , C07K14/515 , C07K14/705 , C12Q1/6809 , C12Q2600/136 , C12Q2600/158 , G01N33/74 , G01N2333/515 , G01N2500/04 , Y10T436/145555
摘要: Human CRB genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of CRB are provided.
摘要翻译: 人CRB基因被鉴定为分支形态发生的调节剂,因此是与缺陷支配形态发生功能相关的病症的治疗靶点。 提供了鉴定分支形态发生调节剂的方法,包括筛选调节CRB活性的试剂。