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公开(公告)号:US09778254B2
公开(公告)日:2017-10-03
申请号:US12669217
申请日:2008-07-18
申请人: Femke Karina De Theije , Thea Van Der Wijk , Albert Hendrik Jan Immink , Eduard Gerard Marie Pelssers , Wilhelmina Maria Hardeman , Sandra Marlin , Gordon Thomas Jowett
发明人: Femke Karina De Theije , Thea Van Der Wijk , Albert Hendrik Jan Immink , Eduard Gerard Marie Pelssers , Wilhelmina Maria Hardeman , Sandra Marlin , Gordon Thomas Jowett
IPC分类号: G01N27/74 , G01N33/543
CPC分类号: G01N33/54366 , G01N27/745 , Y10T29/49885
摘要: A system and method wherein components of a reagent such as labeled antibodies are separated from a biologically active sensor surface by depositing the reagent on a carrier surface distinct from a sensor surface in a detection region. The present device provides a short, well-defined and controlled, pre-incubation time between the particles of interest in the sample fluid and the reagent, thereby increasing the reproducibility by providing all components in one detection region such as a detection chamber.
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公开(公告)号:US20100297780A1
公开(公告)日:2010-11-25
申请号:US12669217
申请日:2008-07-18
申请人: Femke Karina De Theije , Thea Van Der Wijk , Albert Hendrik Jan Immink , Eduard Gerard Marie Pelssers , Wilhelmina Maria Hardeman , Sandra Marlin , Gordon Thomas Jowett
发明人: Femke Karina De Theije , Thea Van Der Wijk , Albert Hendrik Jan Immink , Eduard Gerard Marie Pelssers , Wilhelmina Maria Hardeman , Sandra Marlin , Gordon Thomas Jowett
IPC分类号: G01N33/553 , G01N30/96 , B23P25/00
CPC分类号: G01N33/54366 , G01N27/745 , Y10T29/49885
摘要: A system and method is described wherein components of the reagent (4), e.g. labelled antibodies, are separated from the biologically active sensor surface (5) by depositing the reagent (4) on a carrier surface (3) distinct from the sensor surface (5) in the detection region (2), e.g. detection chamber. In this way, a high assay reproducibility is obtained. By allowing a short, well-defined and controlled, pre-incubation time between the particles of interest, e.g. drugs, in the sample fluid (20) and the reagent (4), the reproducibility will be increased, whereas the speed of the assay is guaranteed by having all components in one detection region (2), e.g. detection chamber.
摘要翻译: 描述了一种系统和方法,其中试剂(4)的组分例如。 通过将试剂(4)沉积在与检测区域(2)中的传感器表面(5)不同的载体表面(3)上,例如从生物活性传感器表面(5)分离。 检测室。 以这种方式,获得高的测定重现性。 通过在感兴趣的颗粒之间允许短的,明确的和受控的预孵育时间,例如。 药物在样品液体(20)和试剂(4)中的重现性将会增加,而测定的速度则通过在一个检测区域(2)中具有所有成分来保证。 检测室。
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