公开(公告)号：US20090297530A1

公开(公告)日：2009-12-03

申请号：US12475009

申请日：2009-05-29

Applicant: Feng Wang-Johanning

Inventor： Feng Wang-Johanning

IPC: A61K39/395 ,  C07K16/10

CPC classification number: C07K16/1036 ,  A61K39/0011 ,  A61K47/6839 ,  A61K47/6855 ,  A61K47/6865 ,  A61K47/6869 ,  A61K2039/505 ,  C07K16/3015 ,  C07K16/3053 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2319/55 ,  C12N2740/10011 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57434 ,  G01N33/57449 ,  G01N33/57484 ,  G01N33/57492

Abstract: Methods and compositions for cancer diagnostics and therapy are provided. More particular, methods and compositions for detecting, preventing, and treating HERV-K+ cancers are provided. One example of a method may involve a method for preventing or inhibiting cancer cell proliferation by administering to a subject a cancer cell proliferation blocking or reducing amount of a HERV-K env protein binding antibody.

Abstract translation: 提供了癌症诊断和治疗的方法和组合物。 提供了更具体的用于检测，预防和治疗HERV-K +癌症的方法和组合物。 方法的一个实例可以涉及通过向受试者施用癌细胞增殖阻断或减少HERV-K env蛋白结合抗体的量来预防或抑制癌细胞增殖的方法。

公开(公告)号：US20240059787A1

公开(公告)日：2024-02-22

申请号：US18245879

申请日：2021-09-18

Applicant: Feng Wang-Johanning ,  Gary Johanning

Inventor： Feng Wang-Johanning ,  Gary Johanning

IPC: C07K16/30 ,  A61K39/00 ,  A61P35/00 ,  C07K16/28

CPC classification number: C07K16/30 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/4644 ,  A61K39/464838 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/2815 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/92

Abstract: The invention provides therapeutic humanized anti-HERV-K antibodies, CAR, or a fusion thereof consisting of a hispecific T ceil engager (BiTE) FOR CD3 and CDS, a DNA-encoded BiTE (DBiTE), or an antibody-drug conjugate (ADC). The invention also relates to peptides, proteins, nucleic acids, and cells for use in immunotherapeutic methods. In particular, the invention relates to the immunotherapy of cancer peptides bound to molecules of the MHC, or peptides as such, which can also be targets of antibodies and other binding molecules.

公开(公告)号：US20080019979A1

公开(公告)日：2008-01-24

申请号：US11752235

申请日：2007-05-22

Applicant: Feng Wang-Johanning

Inventor： Feng Wang-Johanning

IPC: A61K39/395 ,  A61K31/7088 ,  A61P31/12 ,  C07K16/08 ,  C12Q1/02 ,  G01N33/53 ,  C12N15/63 ,  C07H21/00 ,  A61K39/12

CPC classification number: G01N33/57415 ,  A61K39/0011 ,  A61K47/6839 ,  A61K47/6855 ,  A61K47/6865 ,  A61K47/6869 ,  A61K2039/505 ,  C07K16/1036 ,  C07K16/3015 ,  C07K16/3053 ,  C07K16/3069 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/55 ,  G01N33/57407 ,  G01N33/57434 ,  G01N33/57449 ,  G01N33/57484 ,  G01N33/57492

Abstract: Methods and compositions for cancer diagnostics and therapy are provided. More particular, methods and compositions for detecting, preventing, and treating HERV-K+ cancers are provided. One example of a method may involve a method for preventing or inhibiting cancer cell proliferation by administering to a subject a cancer cell proliferation blocking or reducing amount of a HERV-K env protein binding antibody.

Abstract translation: 提供了癌症诊断和治疗的方法和组合物。 更具体地，提供了用于检测，预防和治疗HERV-K + +癌症的方法和组合物。 方法的一个实例可以涉及通过向受试者施用癌细胞增殖阻断或减少HERV-K env蛋白结合抗体的量来预防或抑制癌细胞增殖的方法。