公开(公告)号：US20240415775A1

公开(公告)日：2024-12-19

申请号：US18686557

申请日：2022-10-12

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/24 ,  A61K9/20 ,  A61K31/137 ,  A61K31/167 ,  A61K31/198 ,  A61K31/375 ,  A61K31/485 ,  A61K31/522 ,  A61K36/258

Abstract: An oral chewable tablet contains dextrose in an amount from 50 to 95% by weight of the tablet; and one or more active ingredients in an amount from 0.1 to 50% by weight of the tablet. The oral chewable tablet includes at least two compressed layers containing the dextrose and the one or more active ingredients, the first of the compressed layers being cohered to and adjacent to the second layer.

公开(公告)号：US20190350860A1

公开(公告)日：2019-11-21

申请号：US15982772

申请日：2018-05-17

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/20

Abstract: The invention relates to an oral delivery tablet suitable for active pharmaceutical ingredients comprising a population of particles, the population of particles comprising a) directly compressible (DC) sugar alcohol particles, b) non-directly compressible (non-DC) sugar alcohol particles and c) particles comprising gum base, the non-DC particles providing the tablet with a plurality of discrete non-DC areas, and the non-DC areas resulting in induced saliva generation upon mastication of the tablet, wherein the tablet is designed to be masticated into a coherent residual containing water-insoluble components.

公开(公告)号：US10391054B2

公开(公告)日：2019-08-27

申请号：US15411205

申请日：2017-01-20

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff ,  Kirsten Lund

IPC: A61K31/465 ,  A61K9/20 ,  A61K9/68 ,  A61K9/00 ,  A23G3/36 ,  A23G4/20 ,  A23G4/08 ,  A23G4/18 ,  A24B13/00 ,  A24B15/10 ,  A23L33/10 ,  A23G3/42 ,  A23G4/10

Abstract: The invention relates to a chewable tablet including a polymer system, tobacco powder, flavor and sweetener, at least about 70% by weight of the polymer system being polyvinyl acetate (PVAc) and less than 10% by weight of the polymer system being polymer having a molecular weight (Mw) of greater than about 50000 g/mol.

公开(公告)号：US11351103B2

公开(公告)日：2022-06-07

申请号：US15783151

申请日：2017-10-13

Applicant: Johnson & Johnson Consumer Inc. ,  Fertin Pharma A/S

Inventor： Anthony R. Geonnotti ,  Patricia L. Golas ,  Helle Wittorff ,  Heidi Ziegler Bruun ,  Dorthe Shackinger Boesen

IPC: A61K8/60 ,  A61Q11/00 ,  A61K9/20 ,  A61K8/02 ,  A61K9/00

Abstract: Provided are methods of providing at least one oral care benefit by introducing a tablet into the oral cavity to generate a fluid and forcing at least a portion of fluid generated around the oral cavity, for example, by swishing, rinsing, washing, etc., to provide an oral care benefit.

公开(公告)号：US11260030B2

公开(公告)日：2022-03-01

申请号：US17344373

申请日：2021-06-10

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/20 ,  A61K9/00 ,  A61K31/734 ,  A61K31/165 ,  A61K31/43 ,  A61K31/606 ,  A61K31/708

Abstract: An oral tablet for delivery of active ingredients to the gastrointestinal tract includes a population of particles and an active ingredient to be delivered to the gastrointestinal tract. The population of particles includes directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas, and the non-DC areas resulting in induced saliva generation upon mastication of the tablet, wherein the tablet is designed to be masticated and designed to deliver the active ingredient to the gastrointestinal tract as part of the saliva generated upon mastication of the tablet.

公开(公告)号：US20210346263A1

公开(公告)日：2021-11-11

申请号：US17245330

申请日：2021-04-30

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff ,  Christine Nøhr Pedersen

IPC: A61K8/37 ,  A61Q11/00 ,  A61K8/02

Abstract: A mouthwash and method for oral care benefits includes a swishable powder delivery system having a content of at least two types of sugar alcohol particles with different particle size distributions and one or more active ingredients, the powder delivery system being a dry and flowable population of particles suitable for resembling a liquid mouthwash by swishing the powder delivery system, thereby generating fluid in the oral cavity without adding water.

公开(公告)号：US20210299052A1

公开(公告)日：2021-09-30

申请号：US17344373

申请日：2021-06-10

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/20 ,  A61K9/00 ,  A61K31/165 ,  A61K31/43 ,  A61K31/606 ,  A61K31/708 ,  A61K31/734

Abstract: An oral tablet for delivery of active ingredients to the gastrointestinal tract includes a population of particles and an active ingredient to be delivered to the gastrointestinal tract. The population of particles includes directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas, and the non-DC areas resulting in induced saliva generation upon mastication of the tablet, wherein the tablet is designed to be masticated and designed to deliver the active ingredient to the gastrointestinal tract as part of the saliva generated upon mastication of the tablet.

公开(公告)号：US11096896B2

公开(公告)日：2021-08-24

申请号：US15982810

申请日：2018-05-17

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/20 ,  A61K9/00 ,  A61K45/06 ,  A61K31/465

Abstract: The invention relates to a tablet dosage form for buccal absorption of active ingredients comprising a population of particles and an active ingredient to be released in the oral cavity for absorption through the oral mucosa, the population of particles comprising directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas.

公开(公告)号：US11058641B2

公开(公告)日：2021-07-13

申请号：US15982510

申请日：2018-05-17

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/56 ,  A61K9/20 ,  A61K9/00 ,  A61K31/522

Abstract: The invention relates to an oral tablet for taste masking of active ingredients, the tablet comprising a population of particles and an active ingredient with off-note taste, the population of particles comprising directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas, and the non-DC areas resulting at least partly in induced taste masking of the active ingredient upon mastication of the tablet.

公开(公告)号：US11058633B2

公开(公告)日：2021-07-13

申请号：US15982556

申请日：2018-05-17

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/56 ,  A61K9/00 ,  A61K9/20

Abstract: The invention relates to a disintegrating oral tablet suitable for active pharmaceutical ingredients comprising a population of particles and at least one flavor ingredient, the population of particles comprising directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas, and the non-DC areas resulting in a burst of the at least one flavor ingredient upon mastication of the tablet.