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公开(公告)号：US20110110989A1
公开(公告)日：2011-05-12
申请号：US12866463
申请日：2009-02-11
IPC分类号： A61K8/02 , A61K8/368 , A61K8/64 , A61K8/365 , A61K8/96 , A61K8/66 , A61K8/97 , A61K8/67 , A61K8/99 , A61Q17/04 , A61Q19/00
CPC分类号： A61K8/06 , A61K8/062 , A61K8/8147 , A61K8/8152 , A61K8/8158 , A61K8/87 , A61K8/90 , A61K2800/262 , A61Q1/14 , A61Q19/00
摘要： The present patent application relates to a composition for topical application in the form of an oil-in-water emulsion comprising an oily phase dispersed in an aqueous phase, characterized in that it comprises at least one noncrosslinked amphiphilic polymer, the globules of the said emulsion exhibiting a mean size ranging from 15 to 500 microns and the oily phase being present in an amount of less than 35% by weight, with respect to the total weight of the composition.
摘要翻译： 本专利申请涉及以水包油乳状液形式局部施用的组合物，其包含分散在水相中的油相，其特征在于其包含至少一种非交联的两亲性聚合物，所述乳液的小球 表现出15至500微米的平均尺寸，相对于组合物的总重量，油相的存在量小于35重量％。
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公开(公告)号：US10925815B2
公开(公告)日：2021-02-23
申请号：US12866463
申请日：2009-02-11
摘要： The present patent application relates to a composition for topical application in the form of an oil-in-water emulsion comprising an oily phase dispersed in an aqueous phase, characterized in that it comprises at least one noncrosslinked amphiphilic polymer, the globules of the said emulsion exhibiting a mean size ranging from 15 to 500 microns and the oily phase being present in an amount of less than 35% by weight, with respect to the total weight of the composition.
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3.发明申请Aqueous photoprotective compositions comprising hydrophilic metal oxide nanopigments and polyalkylene glycols of low molecular mass 审中-公开包含亲水性金属氧化物纳米颜料和低分子量聚亚烷基二醇的水性光保护组合物公开(公告)号：US20070166248A1
公开(公告)日：2007-07-19
申请号：US11653394
申请日：2007-01-16
摘要： Stable, reduced whitening photoprotective compositions contain: a) at least one aqueous phase, b) at least hydrophilic inorganic nanopigments based on metal oxides, in an amount ranging from 1% to 25% by weight, with respect to the total weight of the composition, and c) at least one polyalkylene glycol having a molecular mass of less than 8,000 g/mol, formulated into d) a topically applicable, physiologically acceptable medium therefor.
摘要翻译： 稳定的减少美白光保护组合物包含：a）至少一个水相，b）至少基于金属氧化物的亲水性无机纳米颗粒，其量为组合物总重量的1重量％至25重量％ ，和c）至少一种分子量小于8,000g / mol的聚亚烷基二醇，配制成d）局部适用的生理学上可接受的介质。
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公开(公告)号：US20060030655A1
公开(公告)日：2006-02-09
申请号：US11248285
申请日：2005-10-13
CPC分类号： A61Q19/007 , A61K8/062 , A61K9/1075 , A61K2800/21 , A61K2800/262 , B01F17/0028 , B01F17/0085 , B82Y5/00
摘要： These objects and others may be accomplished with the present invention, the first embodiment of which provides an oil-in-water nanoemulsion, which includes: an oily phase dispersed in an aqueous phase; (i) at least one amphiphilic lipid selected from the group including nonionic amphiphilic lipids, anionic amphiphilic lipids, and combinations thereof; and (ii) at least one water-soluble nonionic polymer selected from the group including homopolymers and copolymers of ethylene oxide; polyvinyl alcohols; homopolymers and copolymers of vinylpyrrolidone; homopolymers and copolymers of vinylcaprolactam; homopolymers and copolymers of polyvinyl methyl ether; neutral acrylic homopolymers and copolymers; C1-C2 alkyl celluloses and their derivatives; C1-C3 alkyl guar; C1-C3 hydroxyalkyl guar; and combinations thereof; wherein a ratio of the weight of the oily phase to the weight of the amphiphilic lipid (i) ranges from 1.2 to 10; and wherein the oily phase includes oil globules having a number-average size of less than 100 nm. The nanoemulsion obtained is preferably transparent and stable on storage. It may form a composition for topical, preferably cosmetic or dermatological compositions, pharmaceutical compositions and ophthalmological compositions.
摘要翻译： 这些目的和其它目的可以用本发明来完成，本发明的第一个实施方案提供了一种水包油纳米乳液，其包括：分散在水相中的油相; （i）至少一种选自包括非离子两亲性脂质，阴离子两亲性脂质及其组合的两亲性脂质; 和（ii）至少一种选自包括环氧乙烷的均聚物和共聚物的水溶性非离子聚合物; 聚乙烯醇; 乙烯基吡咯烷酮的均聚物和共聚物; 乙烯基己内酰胺的均聚物和共聚物; 聚乙烯基甲基醚的均聚物和共聚物; 中性丙烯酸均聚物和共聚物; C 1 -C 2烷基纤维素及其衍生物; C 1 -C 3烷基瓜尔胶; C 1 -C 3羟烷基瓜尔胶; 及其组合; 其中所述油相的重量与所述两亲脂质（i）的重量的比率为1.2至10; 并且其中所述油相包括数均分子量小于100nm的油球。 获得的纳米乳液优选在储存时是透明的和稳定的。 它可以形成用于局部，优选化妆品或皮肤病学组合物，药物组合物和眼科学组合物的组合物。
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公开(公告)号：US06998426B2
公开(公告)日：2006-02-14
申请号：US09903768
申请日：2001-07-13
CPC分类号： A61Q19/007 , A61K8/062 , A61K9/1075 , A61K2800/21 , A61K2800/262 , B01F17/0028 , B01F17/0085 , B82Y5/00
摘要： These objects and others may be accomplished with the present invention, the first embodiment of which provides an oil-in-water nanoemulsion, which includes: an oily phase dispersed in an aqueous phase; (i) at least one amphiphilic lipid selected from the group including nonionic amphiphilic lipids, anionic amphiphilic lipids, and combinations thereof; and (ii) at least one water-soluble nonionic polymer selected from the group including homopolymers and copolymers of ethylene oxide; polyvinyl alcohols; homopolymers and copolymers of vinylpyrrolidone; homopolymers and copolymers of vinylcaprolactam; homopolymers and copolymers of polyvinyl methyl ether; neutral acrylic homopolymers and copolymers; C1–C2 alkyl celluloses and their derivatives; C1–C3 alkyl guar; C1–C3 hydroxyalkyl guar; and combinations thereof; wherein a ratio of the weight of the oily phase to the weight of the amphiphilic lipid (i) ranges from 1.2 to 10; and wherein the oily phase includes oil globules having a number-average size of less than 100 nm. The nanoemulsion obtained is preferably transparent and stable on storage. It may form a composition for topical, preferably cosmetic or dermatological compositions, pharmaceutical compositions and ophthalmological compositions.
摘要翻译： 这些目的和其它目的可以用本发明来完成，本发明的第一个实施例提供了一种水包油纳米乳液，其中包括
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6.发明申请Concave or annular particles of silicone materials for increasing the sun protection factor of aqueous photoprotective compositions comprising same 审中-公开用于增加包含其的水性光保护组合物的防晒因子的有机硅材料的凹形或环形颗粒公开(公告)号：US20080044365A1
公开(公告)日：2008-02-21
申请号：US11812901
申请日：2007-06-22
CPC分类号： A61K8/894 , A61K8/0245 , A61K8/891 , A61K2800/412 , A61Q17/04
摘要： Sunscreen compositions having increased SPF contain at least one aqueous phase, at least one organic UV screening agent and/or at least one inorganic UV screening agent, notably at least one wetting agent, and an effective SPF-increasing amount of concave or annular particles of a silicone material, formulated into a physiologically acceptable medium therefor.
摘要翻译： 具有增加的SPF的防晒组合物含有至少一种水相，至少一种有机UV屏蔽剂和/或至少一种无机UV屏蔽剂，特别是至少一种润湿剂和有效的增加SPF的凹或环形颗粒 配制成生理上可接受的介质的有机硅材料。
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公开(公告)号：US10449126B2
公开(公告)日：2019-10-22
申请号：US12637803
申请日：2009-12-15
摘要： The present invention relates to a composition in the form of an emulsion of the oil-in-water type formed of oily globules which are each provided with a lamellar liquid crystal coating and which are dispersed in an aqueous phase, wherein it has a pH ranging from 3 to 5.5 and in that it contains at least one lipophilic surface-active agent with an HLB ranging from 2 to 5, at least one hydrophilic surface-active agent with an HLB ranging from 8 to 12 and at least one amphiphilic compound of ionic nature at a pH ranging from 3 to 5.5.
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8.发明申请Aqueous photoprotective compositions comprising hydrophilic metal oxide nanopigments and vinylpyrrolidone homopolymers 审中-公开包含亲水性金属氧化物纳米颗粒和乙烯基吡咯烷酮均聚物的水性光保护组合物公开(公告)号：US20100254920A1
公开(公告)日：2010-10-07
申请号：US11653392
申请日：2007-01-16
CPC分类号： A61Q17/04 , A61K8/27 , A61K8/29 , A61K8/8176 , A61K2800/413 , B82Y5/00
摘要： Stable, reduced whitening photoprotective compositions contain: a) at least one aqueous phase, b) at least hydrophilic metal oxide nanoparticles, and c) at least one vinylpyrrolidone homopolymer, formulated into d) a topically applicable, physiologically acceptable medium therefor.
摘要翻译： 稳定的减少美白光保护组合物包含：a）至少一个水相，b）至少亲水性金属氧化物纳米颗粒，和c）至少一种乙烯基吡咯烷酮均聚物，配制成d）局部适用的生理上可接受的介质。
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公开(公告)号：US09107843B2
公开(公告)日：2015-08-18
申请号：US13304195
申请日：2011-11-23
申请人： Jean-Thierry Simonnet , Anil Shah , Susan Halpern
发明人： Jean-Thierry Simonnet , Anil Shah , Susan Halpern
摘要： The disclosure relates to sunscreen compositions having a synergistic combination of ultraviolet light (UV) filtering agents that provide a high sun protection factor (SPF). Compositions according to the disclosure have high SPF values without requiring high overall amounts of UV filtering agents. Furthermore, the disclosure relates to methods of using the described compositions for protecting keratinous substances such as skin and hair from UV radiation.
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10.发明授权Vectorization of dsRNA by cationic particles and use of same on a skin model 有权通过阳离子颗粒对dsRNA进行向量化，并在皮肤模型上使用它们公开(公告)号：US09095630B2
公开(公告)日：2015-08-04
申请号：US11436775
申请日：2006-05-19
IPC分类号： A61K48/00 , A61K47/48 , A61K31/713 , B82Y5/00 , C12N15/113
CPC分类号： A61K47/488 , A61K31/713 , A61K47/6907 , A61K47/6911 , B82Y5/00 , C12N15/113
摘要： The present invention relates to vectorization of double stranded RNA oligonucleotides by cationic particles chosen from among surfactant micelles, block or non-block polymer micelles, cationic liposomes and niosomes, cationic oleosomes and cationic nanoemulsions, as well as from among cationic organic or inorganic particles and nanocapsules, and to the use of compositions comprising the association of at least one dsRNA and at least one cationic particle on skin models.
摘要翻译： 本发明涉及通过选自表面活性剂胶束，嵌段或非嵌段聚合物胶束，阳离子脂质体和niosomes，阳离子油质体和阳离子纳米乳液中的阳离子颗粒以及阳离子有机或无机颗粒和 纳米胶囊，以及使用包含至少一种dsRNA和至少一种阳离子颗粒在皮肤模型上缔合的组合物。
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