公开(公告)号：US20130189195A1

公开(公告)日：2013-07-25

申请号：US13796860

申请日：2013-03-12

申请人： Foamix Ltd.

发明人： Dov Tamarkin ,  Doron Friedman ,  Tal Berman ,  Enbal Ziv ,  David Schuz

IPC分类号： A61K9/12

CPC分类号： A61K9/122 ,  A01N25/16 ,  A61K8/046 ,  A61K8/362 ,  A61K8/37 ,  A61K8/4993 ,  A61K8/86 ,  A61K9/0014 ,  A61Q19/00

摘要： The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.

摘要翻译： 本发明教导了一种可发泡药物载体，其包含选自二羧酸和二羧酸酯的有益剂; 选自由至少一种表面活性剂组成的组的稳定剂; 至少一种聚合物及其混合物; 选自水，亲水溶剂，疏水溶剂，有效溶剂，极性溶剂，硅氧烷，软化剂及其混合物的溶剂，其中选择有益剂，稳定剂和溶剂以提供组合物 其基本上耐老化和相分离，或基本上稳定其它活性成分。 本发明还涉及另外含有液化烃气体推进剂的可发泡组合物。

公开(公告)号：US20140248219A1

公开(公告)日：2014-09-04

申请号：US14189559

申请日：2014-02-25

申请人： Foamix Ltd.

发明人： Dov Tamarkin ,  Doron Friedman ,  Enbal Ziv ,  Meir Eini ,  Tal Berman ,  Jorge Danziger ,  Rita Keynan ,  David Schuz

IPC分类号： A61K9/12 ,  A61K47/06

CPC分类号： A61K8/046 ,  A61K8/31 ,  A61K9/0014 ,  A61K9/107 ,  A61K9/122 ,  A61K47/06 ,  A61K2800/31 ,  A61Q19/00 ,  Y10S514/859

摘要： The present invention relates to stable substantially non-aqueous, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum or mixtures thereof, at least one foam agent, at least one propellant, and with and without the addition of an active agent. The formulations may contain a solvent substantially miscible therein. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject in need thereof, comprising administering the above-mentioned compositions to an afflicted target site of said mammalian subject.

摘要翻译： 本发明涉及包含凡士林或其混合物，至少一种泡沫剂，至少一种推进剂，以及加入和不添加活性剂的稳定的基本上非水性，非醇，非硅氧烷，可发泡的载体组合物。 制剂可以含有其中基本上可混溶的溶剂。 本发明还提供了治疗，减轻或预防有此需要的哺乳动物受试者病症的方法，包括将上述组合物施用于所述哺乳动物受试者的受影响的靶位点。