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    Foam Prepared From Nanoemulsions And Uses
    3.
    发明申请
    Foam Prepared From Nanoemulsions And Uses 有权
    从纳米乳液和用途制备的泡沫

    公开(公告)号：US20140193502A1

    公开(公告)日：2014-07-10

    申请号：US14172466

    申请日：2014-02-04

    申请人： Foamix Ltd.

    发明人： Dov Tamarkin ,  Alex Besonov ,  Meir Eini ,  Jorge Danziger

    IPC分类号： A61K9/12

    CPC分类号： A61K9/122 ,  A01N25/16 ,  A61K8/046 ,  A61K8/06 ,  A61K8/062 ,  A61K8/068 ,  A61K8/342 ,  A61K8/375 ,  A61K8/39 ,  A61K8/498 ,  A61K8/4993 ,  A61K8/602 ,  A61K8/73 ,  A61K8/731 ,  A61K8/737 ,  A61K8/8141 ,  A61K8/8147 ,  A61K8/86 ,  A61K8/87 ,  A61K9/0014 ,  A61K9/1075 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/26 ,  A61K47/38 ,  A61K2800/21 ,  A61Q19/00

    摘要： The present invention provides a foamable composition for administration to the skin, body surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory system, vagina or rectum, and methods of using such a composition to treat, alleviate, or prevent a disorder of the skin, body cavity, or mucosal surface. The foamable oil in water nano emulsion composition includes: (a) a nano oil globule system, comprising substantially of sub-micron oil globules; (b) about 0.1% to about 5% by weight of at least one stabilizing agent selected from (i) a non-ionic surfactant, (ii) an ionic surfactant, or (iii) a polymeric agent; and (c) a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition, water and optional ingredients. Upon release from an aerosol container, the foamable composition forms and expanded foam suitable for topical administration.

    摘要翻译： 本发明提供了用于给予皮肤，体表，体腔或粘膜表面的可发泡组合物，例如鼻，口，眼，耳，呼吸系统，阴道或直肠的粘膜，以及使用这种组合物的方法 治疗，减轻或预防皮肤，体腔或粘膜表面的紊乱。 水可发泡油中的纳米乳液组合物包括：（a）纳米油球系统，其基本上包含亚微米级的微球; （b）约0.1％至约5％重量的至少一种稳定剂，其选自（i）非离子表面活性剂，（ii）离子表面活性剂或（iii）聚合物剂; 和（c）浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂，水和任选成分。 当从气溶胶容器释放时，可发泡组合物形成适合局部给药的膨胀泡沫。

    Moisturizing Foam Containing Lanolin
    8.
    发明申请
    Moisturizing Foam Containing Lanolin 审中-公开
    含羊毛脂的保湿泡沫

    公开(公告)号：US20130295022A1

    公开(公告)日：2013-11-07

    申请号：US13911470

    申请日：2013-06-06

    申请人： Foamix Ltd.

    发明人： Doron Friedman ,  Alex Besonov ,  Dov Tamarkin ,  Meir Eini

    IPC分类号： A61K9/12 ,  A61K45/06 ,  A61K31/575

    CPC分类号： A61K45/06 ,  A61K8/046 ,  A61K8/062 ,  A61K8/31 ,  A61K9/0014 ,  A61K9/107 ,  A61K9/122 ,  A61K31/575 ,  A61Q19/00

    摘要： The present invention provides a highly tolerable, hydrating lanolin containing foamable composition for administration to the skin, body surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory system, vagina or rectum. The foamable composition includes lanolin, a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent, water, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

    摘要翻译： 本发明提供了一种用于给予皮肤，身体表面，体腔或粘膜表面的高度耐受的水合羊毛脂含可发泡组合物，例如鼻，口，眼，耳，呼吸系统，阴道或直肠的粘膜。 可发泡组合物包括羊毛脂，表面活性剂，约0.01％至约5％重量的至少一种聚合物添加剂，其选自生物粘附剂，胶凝剂，成膜剂和相变剂 ，水和液化或压缩气体推进剂，其浓度为总组合物重量的约3％至约25％。

    DICARBOXYLIC ACID FOAMABLE VEHICLE AND PHARMACEUTICAL COMPOSITIONS THEREOF
    9.
    发明申请
    DICARBOXYLIC ACID FOAMABLE VEHICLE AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开
    二羧酸可燃性汽车及其药用组合物

    公开(公告)号：US20130189195A1

    公开(公告)日：2013-07-25

    申请号：US13796860

    申请日：2013-03-12

    申请人： Foamix Ltd.

    发明人： Dov Tamarkin ,  Doron Friedman ,  Tal Berman ,  Enbal Ziv ,  David Schuz

    IPC分类号： A61K9/12

    CPC分类号： A61K9/122 ,  A01N25/16 ,  A61K8/046 ,  A61K8/362 ,  A61K8/37 ,  A61K8/4993 ,  A61K8/86 ,  A61K9/0014 ,  A61Q19/00

    摘要： The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.

    摘要翻译： 本发明教导了一种可发泡药物载体，其包含选自二羧酸和二羧酸酯的有益剂; 选自由至少一种表面活性剂组成的组的稳定剂; 至少一种聚合物及其混合物; 选自水，亲水溶剂，疏水溶剂，有效溶剂，极性溶剂，硅氧烷，软化剂及其混合物的溶剂，其中选择有益剂，稳定剂和溶剂以提供组合物 其基本上耐老化和相分离，或基本上稳定其它活性成分。 本发明还涉及另外含有液化烃气体推进剂的可发泡组合物。

    Foamable Vehicle and Pharmaceutical Compositions Thereof
    10.
    发明申请
    Foamable Vehicle and Pharmaceutical Compositions Thereof 有权
    可发泡车辆及其药物组合物

    公开(公告)号：US20130189193A1

    公开(公告)日：2013-07-25

    申请号：US13793893

    申请日：2013-03-11

    申请人： Foamix Ltd.

    发明人： Dov Tamarkin ,  Doron Friedman ,  Meir Eini ,  Alex Besonov

    IPC分类号： A61K47/10

    CPC分类号： A61K47/10 ,  A01N25/16 ,  A61K8/046 ,  A61K9/0014 ,  A61K9/0034 ,  A61K9/12 ,  A61K9/122 ,  A61K47/14 ,  A61K47/38 ,  A61Q19/00 ,  Y10S514/945 ,  A01N53/00

    摘要： A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

    摘要翻译： 吸湿性药物组合物包括至少一种浓度足以提供至少0.9的Aw值的吸湿物质和抗感染剂。 起泡药物载体包括约50％至约98％的选自多元醇和PEG的极性溶剂; 0％至约48％的第二极性溶剂; 约0.2重量％至约5重量％的表面活性剂; 约0.01重量％至约5重量％的至少一种聚合物; 和以总组合物重量计约3％至约25％浓度的液化或压缩气体推进剂。