Antiangiogenic drug to treat cancer, arthritis and retinopathy
    4.
    发明授权
    Antiangiogenic drug to treat cancer, arthritis and retinopathy 失效
    抗血管生成药物治疗癌症,关节炎和视网膜病变

    公开(公告)号:US5932545A

    公开(公告)日:1999-08-03

    申请号:US39682

    申请日:1998-03-16

    IPC分类号: A61K38/00 C07K14/78

    CPC分类号: C07K14/78 A61K38/00 Y02P20/55

    摘要: Peptides having the formula:T-Gly-Val-D-Ile-Thr-Arg-Ile-U,V-Gly-D-Val-Ile-D-Thr-D-Arg-D-Ile-W,X-D-Arg-D-Ile-D-Arg-D-Thr-lle-D-Val-Y, andZ-Gly-Val-Ile-Thr-Arg-Ile-Uwherein T is absent or is selected from N-protecting group and a polypeptide of up to 12 amino acid residues optionally terminated with a N-protecting group; U is selected from Arg and Arg-NR.sup.1 R.sup.2 wherein R.sup.1 and R.sup.2 are independently selected from hydrogen and alkyl of one to four carbon atoms; V is absent or a N-protecting group; W is selected from D-Arg and D-Arg-NR.sup.1 R.sup.2 ; X is absent or a N-protecting group; Y is selected from Gly and Gly-NR.sup.1 R.sup.2 ; and Z is 1-12 amino acid residues optionally terminated with a N-protecting group wherein at least one of the amino acid residues is a D-amino acid residue inhibit angiogenesis and are useful in the treatment of disease states such as cancer, arthritis, macular degeneration and diabetic retinopathyin which angiogenesis plays a role.

    摘要翻译: 具有下式的肽:T-Gly-Val-D-Ile-Thr-Arg-Ile-U,V-Gly-D-Val-Ile-D-Thr-D-Arg-D-Il eW,XD-Arg- D-Ile-D-Arg-D-Thr-Lle-D-Val-Y和Z-Gly-Val-Ile-Thr-Arg-Ile-U,其中T不存在或选自N-保护基和 最多12个氨基酸残基,任选以N-保护基终止; U选自Arg和Arg-NR1R2,其中R1和R2独立地选自氢和1-4个碳原子的烷基; V不存在或N-保护基; W选自D-Arg和D-Arg-NR1R2; X不存在或N-保护基; Y选自Gly和Gly-NR1R2; Z为1-12个氨基酸残基,任选以N-保护基终止,其中至少一个氨基酸残基为D-氨基酸残基,抑制血管生成,可用于治疗疾病状态,如癌症,关节炎, 黄斑变性和血管生成发挥作用的糖尿病视网膜病变。

    Intelligent audio selector
    6.
    发明申请
    Intelligent audio selector 失效
    智能音频选择器

    公开(公告)号:US20070266843A1

    公开(公告)日:2007-11-22

    申请号:US11784702

    申请日:2007-04-09

    IPC分类号: G10H7/00

    摘要: A digital music player includes an audio file selector that selects a subsequent audio file to play from a collection of audio files based upon a desired relationship between an audio characteristic of a current audio file and an audio characteristic of the subsequent audio file. The audio selector digitally analyzes the audio files to determine their audio characteristics. A weighting procedure then assigns weights to the audio files in the collection based upon their audio characteristics and their relationship to the audio characteristics of the current audio file. A random selector then pseudo randomly selects the subsequent audio files from a weighted list of the files. The desired relationship can be a specified correspondence between a key or tempo of the current audio file and a key or tempo of the subsequent audio file. The audio selector is preferably implemented through a software macro which is downloaded into an existing digital music player.

    摘要翻译: 数字音乐播放器包括音频文件选择器,其基于当前音频文件的音频特性和后续音频文件的音频特性之间的期望关系,从音频文件的集合中选择随后的音频文件进行播放。 音频选择器对音频文件进行数字分析,以确定其音频特性。 然后,加权过程基于它们的音频特性及其与当前音频文件的音频特性的关系,给集合中的音频文件分配权重。 随机选择器随后从文件的加权列表中随机选择随后的音频文件。 期望的关系可以是当前音频文件的键或速度与后续音频文件的键或速度之间的指定对应关系。 音频选择器优选地通过下载到现有数字音乐播放器中的软件宏实现。

    Intelligent audio selector
    9.
    发明授权
    Intelligent audio selector 失效
    智能音频选择器

    公开(公告)号:US07612280B2

    公开(公告)日:2009-11-03

    申请号:US11784702

    申请日:2007-04-09

    IPC分类号: G10H1/00 G10H1/18

    摘要: A digital music player includes an audio file selector that selects a subsequent audio file to play from a collection of audio files based upon a desired relationship between an audio characteristic of a current audio file and an audio characteristic of the subsequent audio file. The audio selector digitally analyzes the audio files to determine their audio characteristics. A weighting procedure then assigns weights to the audio files in the collection based upon their audio characteristics and their relationship to the audio characteristics of the current audio file. A random selector then pseudo randomly selects the subsequent audio files from a weighted list of the files. The desired relationship can be a specified correspondence between a key or tempo of the current audio file and a key or tempo of the subsequent audio file. The audio selector is preferably implemented through a software macro which is downloaded into an existing digital music player.

    摘要翻译: 数字音乐播放器包括音频文件选择器,其基于当前音频文件的音频特性和后续音频文件的音频特性之间的期望关系,从音频文件的集合中选择随后的音频文件进行播放。 音频选择器对音频文件进行数字分析,以确定其音频特性。 然后,加权过程基于它们的音频特性及其与当前音频文件的音频特性的关系,给集合中的音频文件分配权重。 随机选择器随后从文件的加权列表中随机选择随后的音频文件。 期望的关系可以是当前音频文件的键或速度与后续音频文件的键或速度之间的指定对应关系。 音频选择器优选地通过下载到现有数字音乐播放器中的软件宏实现。

    SYSTEM AND METHOD FOR RENDERING ANTI-ALIASED TEXT TO A VIDEO SCREEN
    10.
    发明申请
    SYSTEM AND METHOD FOR RENDERING ANTI-ALIASED TEXT TO A VIDEO SCREEN 审中-公开
    用于将反病毒文本渲染到视频屏幕的系统和方法

    公开(公告)号:US20130120657A1

    公开(公告)日:2013-05-16

    申请号:US13294139

    申请日:2011-11-10

    IPC分类号: G09G5/00 H04N5/00

    摘要: Text is rendered to a television screen using only the alpha channel. This is accomplished by delaying blending with underlying video until the end of the process to thereby preserve the alpha channel information. Glyphs are used to graphically represent character data in the text to be rendered. Glyphs can be stored in a character texture. In addition, the glyphs can be contained in rectangles having identifiable locations in the character texture. The rectangles can have sizes dependent upon the glyph the rectangle contains.

    摘要翻译: 文本仅使用Alpha通道呈现给电视屏幕。 这是通过延迟与底层视频的混合来实现的,直到过程结束,从而保留Alpha通道信息。 字形用于图形化地表示要呈现的文本中的字符数据。 字形可以存储在字符纹理中。 此外,字形可以包含在具有字符纹理中的可识别位置的矩形中。 矩形可以具有取决于矩形包含的字形的大小。