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公开(公告)号：US20070149549A1
公开(公告)日：2007-06-28
申请号：US11618932
申请日：2007-01-01
申请人： Francine Li , Kenneth Rehder , Michael Campbell , Celeste Viscardi , Jon-Paul Strachan , Zhengming Guo
发明人： Francine Li , Kenneth Rehder , Michael Campbell , Celeste Viscardi , Jon-Paul Strachan , Zhengming Guo
IPC分类号： A61K31/506 , A61K31/497 , A61K31/454 , A61K31/4439 , A61K31/426 , A61K31/42 , A61K31/4178 , A61K31/416 , C07D417/14 , C07D413/14 , C07D409/02
CPC分类号： C07D231/12 , C07D231/22 , C07D401/04 , C07D401/14 , C07D409/14 , C07D471/04
摘要： The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
摘要翻译： 本发明涉及可用于治疗与蛋白质与其药学上可接受的盐的异戊二烯化有关的疾病的化合物，其包含其的药物组合物，以及用于抑制蛋白质异戊烯化的方法。
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2.发明申请Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use 审中-公开含有二甲基环丁烷的丙炔基化抑制剂及其合成和使用方法公开(公告)号：US20050004122A1
公开(公告)日：2005-01-06
申请号：US10636312
申请日：2003-08-06
IPC分类号： C07D231/12 , C07D231/22 , C07D401/04 , C07D401/14 , C07D403/04 , C07D409/14 , C07D417/04 , C07D471/04 , A61K31/53 , A61K31/4245 , A61K31/433 , A61K31/506
CPC分类号： C07D231/12 , C07D231/22 , C07D401/04 , C07D401/14 , C07D403/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04
摘要： The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
摘要翻译： 本发明涉及可用于治疗与蛋白质与其药学上可接受的盐的异戊二烯化有关的疾病的化合物，其包含其的药物组合物，以及用于抑制蛋白质异戊烯化的方法。
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3.发明申请PRENYLATION INHIBITORS CONTAINING DIMETHYLCYCLOBUTANE AND METHODS OF THEIR SYNTHESIS AND USE 审中-公开含二甲基胆碱酯酶的重组抑制剂及其合成与使用方法公开(公告)号：US20080119524A1
公开(公告)日：2008-05-22
申请号：US12020475
申请日：2008-01-25
IPC分类号： A61K31/4439 , C07D401/04
CPC分类号： C07D231/12 , C07D231/22 , C07D401/04 , C07D401/14 , C07D403/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04
摘要： The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
摘要翻译： 本发明涉及可用于治疗与蛋白质与其药学上可接受的盐的异戊二烯化有关的疾病的化合物，其包含其的药物组合物，以及用于抑制蛋白质异戊烯化的方法。
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公开(公告)号：US07452889B2
公开(公告)日：2008-11-18
申请号：US11845720
申请日：2007-08-27
申请人： Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Kenneth Rehder , Jeff Zablocki
发明人： Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Kenneth Rehder , Jeff Zablocki
IPC分类号： A61K31/496 , C07D417/12
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
摘要翻译： 公开了具有式I结构的新型取代的杂环衍生物：该化合物可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变异）心绞痛，稳定和不稳定型心绞痛， 运动诱发心绞痛，充血性心脏病，糖尿病和心肌梗死。
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公开(公告)号：US20090054457A1
公开(公告)日：2009-02-26
申请号：US12259085
申请日：2008-10-27
IPC分类号： A61K31/496 , C07D417/02 , A61K31/454 , A61P3/10 , A61P21/00 , A61P9/00
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
摘要翻译： 公开了具有式I结构的新型取代的杂环衍生物：该化合物可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变异）心绞痛，稳定和不稳定型心绞痛， 运动诱发心绞痛，充血性心脏病，糖尿病和心肌梗死。
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公开(公告)号：US20080032993A1
公开(公告)日：2008-02-07
申请号：US11845720
申请日：2007-08-27
IPC分类号： A61K31/496 , A61K31/4468 , A61P3/10 , A61P9/00 , C07D277/64 , C07D409/14
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
摘要翻译： 公开了具有式I结构的新型取代的杂环衍生物：该化合物可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变异）心绞痛，稳定和不稳定型心绞痛， 运动诱发心绞痛，充血性心脏病，糖尿病和心肌梗死。
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公开(公告)号：US20050197346A1
公开(公告)日：2005-09-08
申请号：US11015915
申请日：2004-12-17
IPC分类号： A61K31/496 , C07D211/58 , C07D277/64 , C07D417/02 , C07D417/12
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
摘要翻译： 公开了具有式I结构的新型取代的杂环衍生物：该化合物可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变异）心绞痛，稳定和不稳定型心绞痛， 运动诱发心绞痛，充血性心脏病，糖尿病和心肌梗死。
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公开(公告)号：US20060229317A1
公开(公告)日：2006-10-12
申请号：US11452479
申请日：2006-06-13
IPC分类号： A61K31/496 , C07D417/14 , C07D413/14
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
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公开(公告)号：US20060025454A1
公开(公告)日：2006-02-02
申请号：US11237134
申请日：2005-09-27
申请人： Bradley Brown , Kenneth Rehder
发明人： Bradley Brown , Kenneth Rehder
IPC分类号： A61K31/4439 , C07D403/04
CPC分类号： C07D231/12 , C07D231/22 , C07D401/04 , C07D401/14 , C07D409/14 , C07D471/04
摘要： The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
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公开(公告)号：US07262198B2
公开(公告)日：2007-08-28
申请号：US11452479
申请日：2006-06-13
申请人： Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Kenneth Rehder , Jeff Zablocki
发明人： Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Kenneth Rehder , Jeff Zablocki
IPC分类号： A61K31/496 , C07D277/64
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
摘要翻译： 公开了具有式I结构的新型取代的杂环衍生物：该化合物可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变异）心绞痛，稳定和不稳定型心绞痛， 运动诱发心绞痛，充血性心脏病，糖尿病和心肌梗死。
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