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公开(公告)号：US06995184B2
公开(公告)日：2006-02-07
申请号：US10416617
申请日：2001-11-21
申请人： Francis Barth , Christian Congy , Carole Guillaumont , Murielle Rinaldi , Fabienne Vasse , Claude Vernhet
发明人： Francis Barth , Christian Congy , Carole Guillaumont , Murielle Rinaldi , Fabienne Vasse , Claude Vernhet
IPC分类号： A61K31/404 , A61K31/405 , C07D209/08
CPC分类号： C07D209/12
摘要： A subject-matter of the present invention is compounds of formula: and their preparation and the pharmaceutical compositions comprising them. These compounds are agonists for CB2 cannabinoid receptors.
摘要翻译： 本发明的主题是下式的化合物：化学式id =“CHEM-US-00001”num =“000
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2.发明授权Indole derivatives, method for preparing same and pharmaceutical compositions containing same 失效吲哚衍生物，其制备方法和含有它们的药物组合物公开(公告)号：US07138424B2
公开(公告)日：2006-11-21
申请号：US10514309
申请日：2003-05-15
IPC分类号： A61K31/404 , C07D209/14
CPC分类号： C07D209/14
摘要： The present invention provides compounds of formula: and also provides their preparation and the pharmaceutical compositions comprising them. These compounds are ligands of CB2 cannabinoid receptors.
摘要翻译： 本发明提供式的化合物，并且还提供其制备方法和包含它们的药物组合物。 这些化合物是CB 2/2大麻素受体的配体。
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3.发明申请Indole derivatives, method for preparating same and pharmaceutical compositions containing same 失效吲哚衍生物，其制备方法和含有其的药物组合物公开(公告)号：US20060089345A1
公开(公告)日：2006-04-27
申请号：US10514309
申请日：2003-05-15
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/405 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D209/14
摘要： The present invention provides compounds of formula: and also provides their preparation and the pharmaceutical compositions comprising them. These compounds are ligands of CB2 cannabinoid receptors.
摘要翻译： 本发明提供式的化合物，并且还提供其制备方法和包含它们的药物组合物。 这些化合物是CB 2/2大麻素受体的配体。
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公开(公告)号：US07741363B2
公开(公告)日：2010-06-22
申请号：US12120509
申请日：2008-05-14
IPC分类号： A61K31/405 , C07D209/12
CPC分类号： C07D209/14 , C07D209/12
摘要： The invention relates to compounds of formula (I), wherein X, R1, R2, R3, R4 and R5 are as described herein. The invention also includes preparative methods for the preparation of compounds of formula (I). A method for the therapeutic use of the inventive compounds is also disclosed and claimed.
摘要翻译： 本发明涉及式（I）化合物，其中X，R 1，R 2，R 3，R 4和R 5如本文所述。 本发明还包括制备式（I）化合物的制备方法。 还公开并要求保护本发明化合物的治疗用途的方法。
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公开(公告)号：US08680102B2
公开(公告)日：2014-03-25
申请号：US12942780
申请日：2010-11-09
IPC分类号： A61K31/496 , C07D403/02
CPC分类号： C07D401/14 , C07D401/06
摘要： The subject of the invention is compounds of formula (I): in which R1-R10 are as defined within, the method of preparation and therapeutic application as cannabinoid CB1 receptor antagonists.
摘要翻译： 本发明的主题是式（I）化合物：其中R 1 -R 10如上所定义，作为大麻素CB1受体拮抗剂的制备方法和治疗应用。
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公开(公告)号：US20110152320A1
公开(公告)日：2011-06-23
申请号：US12942780
申请日：2010-11-09
IPC分类号： A61K31/4545 , C07D401/14 , C07D401/06 , A61K31/454 , A61P29/00 , A61P25/04 , A61P35/00 , A61P1/00 , A61P19/02 , A61P25/16 , A61P25/28
CPC分类号： C07D401/14 , C07D401/06
摘要： The subject of the invention is compounds of formula (I): in which R1-R10 are as defined within, the method of preparation and therapeutic application as cannabinoid CB1 receptor antagonists.
摘要翻译： 本发明的主题是式（I）化合物：其中R 1 -R 10如上所定义，作为大麻素CB1受体拮抗剂的制备方法和治疗应用。
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![N-[(4,5-diphenyl-3-alkyl-2-thienyl)methyl]amine [amide, sulfonamide, carbamate and urea) derivatives as cannabinoid CB1 receptor antagonists](/abs-image/US/2010/03/09/US07674821B2/abs.jpg.150x150.jpg)
7.发明授权N-[(4,5-diphenyl-3-alkyl-2-thienyl)methyl]amine [amide, sulfonamide, carbamate and urea) derivatives as cannabinoid CB1 receptor antagonists 失效N - [（4,5-二苯基-3-烷基-2-噻吩基）甲基]胺[酰胺，磺酰胺，氨基甲酸酯和尿素）衍生物作为大麻素CB1受体拮抗剂公开(公告)号：US07674821B2
公开(公告)日：2010-03-09
申请号：US11764378
申请日：2007-06-18
IPC分类号： A61K31/381 , C07D333/22
CPC分类号： C07D333/20
摘要： The invention concerns compounds of formula (I), wherein X, R1, R2, R3, R4 and R5 are as defined herein. The invention also concerns a method for preparing said compounds and their use as cannabinoid CB1 receptor antagonists.
摘要翻译： 本发明涉及式（I）化合物，其中X，R 1，R 2，R 3，R 4和R 5如本文所定义。 本发明还涉及制备所述化合物的方法及其作为大麻素CB1受体拮抗剂的用途。
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公开(公告)号：US07381727B2
公开(公告)日：2008-06-03
申请号：US11625616
申请日：2007-01-22
IPC分类号： A61K31/4025 , A61K31/445 , A61K31/496 , C07D207/30 , C07D401/02 , C07D403/02
CPC分类号： C07D409/12 , C07D207/34 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The invention concerns compounds of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. The invention also concerns the method for preparing said compounds and their therapeutic use.
摘要翻译： 本发明涉及式（I）的化合物：其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，R 8和R 9， 如本文所定义。 本发明还涉及制备所述化合物的方法及其治疗用途。
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公开(公告)号：US20050192332A1
公开(公告)日：2005-09-01
申请号：US11119074
申请日：2005-04-29
IPC分类号： A61K31/4162 , A61K31/438 , A61K31/4439 , A61K31/454 , A61K31/55 , A61P1/00 , A61P1/12 , A61P3/04 , A61P3/10 , A61P13/00 , A61P15/00 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P29/00 , A61P31/00 , A61P35/00 , A61P43/00 , C07D231/54 , C07D231/56 , C07D401/12 , C07D495/04 , C07D498/02
CPC分类号： C07D231/56 , C07D231/54 , C07D495/04
摘要： The subject of the invention is tricyclic derivatives of pyrazolecarboxylic acid of formula: in which R1 represents a C3-C15 carboxyl radical or an NR2R3 group. The invention also relates to the method for preparing the compounds of formula (I), pharmaceutical compositions containing them. The compounds of formula (I) are active on cannabinoid CB1 receptors.
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10.发明授权(1,5-diphenyl-1H-pyrazol-3-yl)oxadiazole derivatives, preparation method thereof and use of same in therapeutics 失效（1,5-二苯基-1H-吡唑-3-基）恶二唑衍生物及其制备方法及其在治疗中的应用公开(公告)号：US07632852B2
公开(公告)日：2009-12-15
申请号：US11835670
申请日：2007-08-08
申请人： Francis Barth , Christian Congy , Patrick Gueule , Murielle Rinaldi-Carmona , Didier Van Broeck
发明人： Francis Barth , Christian Congy , Patrick Gueule , Murielle Rinaldi-Carmona , Didier Van Broeck
IPC分类号： A61K31/4155 , A61K31/4245 , C07D271/10 , C07D231/10
CPC分类号： C07D413/04
摘要： The invention relates to compounds having formula (I): Wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to a method of preparing said compounds and to the application thereof in therapeutics.
摘要翻译： 本发明涉及具有式（I）的化合物：其中R1，R2，R3和R4如本文所定义。 本发明还涉及制备所述化合物的方法及其在治疗中的应用。
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