专利检索 ap:("Francis Boyle" OR "Jon Curwen" OR "Neil Gallagher" OR "Ursula Hancox" OR "Andrew Hughes" OR "Donna Johnstone" OR "Sian Taylor" OR "David Tonge") AND inv:"Jon Curwen" 第 1 页

1.

发明申请
Therapeutic treatment 审中-公开
标题翻译：治疗治疗

公开(公告)号：US20060122180A1

公开(公告)日：2006-06-08

申请号：US10530794

申请日：2003-10-07

申请人： Francis Boyle , Jon Curwen , Neil Gallagher , Ursula Hancox , Andrew Hughes , Donna Johnstone , Sian Taylor , David Tonge

发明人： Francis Boyle , Jon Curwen , Neil Gallagher , Ursula Hancox , Andrew Hughes , Donna Johnstone , Sian Taylor , David Tonge

IPC分类号： A61K31/5377 , A61K31/517 , A61K31/4965 , A61K31/497 , A61K31/422 , A61K31/42

CPC分类号： A61K45/06 , A61K31/517 , A61K2300/00

摘要： A combination, comprising an endothelin receptor antagonist, or a pharmaceutically acceptable salt thereof, and an EGFR TKI, or a pharmaceutically acceptable salt thereof is described.

摘要翻译： 描述了包含内皮素受体拮抗剂或其药学上可接受的盐和EGFR TKI或其药学上可接受的盐的组合。

2.

发明申请
5-ht 1b/1d receptor agonists for the treatment of headache resulting from administering an endothelin receptor antagonist 审中-公开
标题翻译： 5-ht 1b / 1d受体激动剂用于治疗由内皮素受体拮抗剂引起的头痛

公开(公告)号：US20060009512A1

公开(公告)日：2006-01-12

申请号：US10530232

申请日：2003-10-06

申请人： Jon Curwen , Andrew Hughes , Donna Johnstone , Clive Morris

发明人： Jon Curwen , Andrew Hughes , Donna Johnstone , Clive Morris

IPC分类号： A61K31/405 , C07D209/18

CPC分类号： A61K45/06 , A61K31/00 , A61K31/18 , A61K31/192 , A61K31/216 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/422 , A61K31/445 , A61K31/48 , A61K31/506 , A61K31/635 , A61K2300/00

摘要： The use of a 5-HT1B/1D receptor agonist in the treatment or prevention of headache that results from administering an endothelin receptor antagonist; and the combination, comprising an endothelin receptor antagonist and a 5-HT1B/1D receptor agonist is described.

摘要翻译： 使用5-HT 1B / 1D受体激动剂治疗或预防由施用内皮素受体拮抗剂引起的头痛; 并描述了包含内皮素受体拮抗剂和5-HT 1B / 1D受体激动剂的组合。

3.

发明申请
Therapeutic agents comprising an anti-angiogenic agent in combination with an src-inhibitor and their therapeutic use 审中-公开
标题翻译：包含与src抑制剂组合的抗血管生成剂及其治疗用途的治疗剂

公开(公告)号：US20060223815A1

公开(公告)日：2006-10-05

申请号：US10555389

申请日：2004-05-04

申请人： Jon Curwen , Stephen Wedge

发明人： Jon Curwen , Stephen Wedge

IPC分类号： A61K31/517

CPC分类号： A61K45/06

摘要： The invention relates to the use of an anti-angiogenic agent in combination with an inhibitor of the Src family of non-receptor tyrosine kinases in the manufacture of a medicament for use in the substantially normotensive treatment in a warm-blooded mammal such as a human being of a disease state associated with angiogenesis, the Src kinase inhibitor being administered in an amount effective to counteract substantially the hypertension induced by the anti-angiogenic agent.

摘要翻译： 本发明涉及抗血管生成剂与非受体酪氨酸激酶的Src家族的抑制剂的组合在制备用于在温血哺乳动物（例如人）中基本上正常血压治疗的药物中的用途作为与血管生成相关的疾病状态，Src激酶抑制剂以有效抵消由抗血管生成剂诱导的高血压的量的量施用。