摘要:
A combination, comprising an endothelin receptor antagonist, or a pharmaceutically acceptable salt thereof, and an EGFR TKI, or a pharmaceutically acceptable salt thereof is described.
摘要:
The use of N-(3-methoxy-5-methylpyrazin-2-yl)-2-(4-[1,3,4-oxadiazol-2-yl]phenyl)pyridine-3-sulphonamide, or a pharmaceutically acceptable salt thereof, in the treatment of cancer and/or pain in a warm blooded animal such as man is described.
摘要:
The use of a 5-HT1B/1D receptor agonist in the treatment or prevention of headache that results from administering an endothelin receptor antagonist; and the combination, comprising an endothelin receptor antagonist and a 5-HT1B/1D receptor agonist is described.
摘要:
A combination, comprising N-(3-methoxy-5-methylpyrazin-2-yl)-2-(4-[1,3,4-oxadiazol-2-yl]phenyl)pyridine-3-sulphonamide and an anti-mitotic cytotoxic agent.
摘要:
A combination, comprising N-(3-methoxy-5-methylpyrazin-2-yl)-2-(4-[1,3,4-oxadiazol-2-yl]phenyl)pyridine-3-sulphonamide and an anti-mitotic cytotoxic agent.
摘要:
The present invention meets one or more of the above needs and is a composition comprising plurality of capsules wherein the capsules comprise: a core of one or more highly polar liquids; one or more polar active materials dissolved in or dispersed in one or more highly polar liquids; a mixture of one or more polymers and one of more highly polar liquids; or a mixture of one or more polymers, one or more highly polar liquids and one or more polar active materials, and a shell comprising, particles in a polymer matrix or particles; wherein the thickness of the shell is sufficient to prevent passage of the highly polar liquid or the active material through the shell or to control the rate passage of the highly polar liquid or the active material through the shell with the proviso that the one or more polymers may be located in the core, in the polymer matrix of the shell or both.
摘要:
In a method of and apparatus for manufacturing a filtering screen, a frame of plastics coated metal or reinforced plastics material is located in a jig and at least two sheets of wire cloths are placed over the frame and their edges gripped by pneumatically operated clamps carried by the jig. The clamps are pneumatically driven outwardly of the frame to tension each cloth in orthogonal directions. The tensioned cloths are pressed against the frame and heated in order to bond the cloths to the frame. The heated material is allowed to cool, and after completion of the bonding step the clamps are released, allowing the frame to be removed from the jig. Where necessary the cloths are trimmed back to the edges of the frame. A separate set of pneumatically operated clamps may be provided for gripping all four edges of each wire cloth layer to allow each layer to be individually tensioned.
摘要:
A sifting screen is described comprising a rigid frame, a first woven cloth of hard wearing metal wire, stretched thereacross and secured thereto, and a second woven cloth having a coarser mesh than the first cloth and being woven from an elongate material of greater cross-section than the first, also stretched across the frame, and secured thereto, below the first cloth, to support the latter against sagging. In accordance with the invention, at least the wearing surface of the material from which the lower cloth is woven is selected to be significantly less hard wearing than that from which the upper cloth is woven, so that wear due to rubbing and vibration during use, occurs to a greater extent in the lower cloth than in the upper cloth. In one example the upper cloth is woven from stainless steel wire and the lower from phosphor bronze wire. In another example the lower cloth is of wire having a coating of an epoxy based material, or Teflon (TM), or Molybdenum Disulphide. In another example the lower cloth is formed from a plastics material or Kevlar (TM) or carbon fibre. The frame may be formed from glass reinforced gas blown polypropylene reinforced by elongate metal reinforcing elements or rods.