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    19-nor steroids having a thiocarbonated chain in position 11beta, their preparation process and the intermediates of this process, and the intermediates of this process, their use as medicaments and compositions
    2.
    发明授权
    19-nor steroids having a thiocarbonated chain in position 11beta, their preparation process and the intermediates of this process, and the intermediates of this process, their use as medicaments and compositions 失效
    19-还没有在位置11beta具有硫代碳链的类固醇，其制备方法和该方法的中间体，以及该方法的中间体，它们作为药物和组合物的用途

    公开(公告)号：US06281204B1

    公开(公告)日：2001-08-28

    申请号：US08244735

    申请日：1994-06-09

    申请人： Andre Claussner ,  Francois Nique ,  Jean-Georges Teutsch ,  Patrick Van De Velde

    发明人： Andre Claussner ,  Francois Nique ,  Jean-Georges Teutsch ,  Patrick Van De Velde

    IPC分类号： A61K3158

    CPC分类号： C07J31/006 ,  C07J41/0005 ,  C07J41/0016 ,  C07J41/0083 ,  C07J43/003

    摘要： Compounds of formula (I), wherein R17 and R′17 are such that: either R17 and R′17 together form ketone, hydrazono, oxime or methylene, or R17 is hydroxyl, hydroxymethyl or acyloxy and R′17 is hydrogen, alkyl or optionally substitued alkenyl or alkynyl; R3 is hydrogen or alkyl; R16 is hydrogen, halogen or alkyl; m is 0, 1 or 2; X, Y and Z are such that: X is methylene, arylene or arylenoxy bonded to the steroid by a carbon atom; Y is a saturated or unsaturated straight or branched aliphatic chain which is optionally interrupted by oxygen; and Z is aryl, arylalkyl or straight or branched alkyl; addition salts thereof, a preparation method therefor, medicinal uses thereof, compositions containing said compounds, and resulting novel intermediates.

    摘要翻译： 式（I）化合物，其中R 17和R 17如此：R 17和R 17一起形成酮，亚肼基，肟或亚甲基，或R 17为羟基，羟甲基或酰氧基，R 17为氢，烷基或 任选取代的烯基或炔基; R3是氢或烷基; R16是氢，卤素或烷基; m为0,1或2; X，Y和Z使得：X是亚甲基，亚芳基或亚芳基氧基通过碳原子键合到类固醇; Y是任选被氧中断的饱和或不饱和直链或支链脂族链; Z为芳基，芳烷基或直链或支链烷基; 其加成盐，其制备方法，其医药用途，含有所述化合物的组合物，以及所得的新型中间体。