公开(公告)号：US08244331B2

公开(公告)日：2012-08-14

申请号：US12229754

申请日：2008-08-26

申请人： Frank Deinzer ,  Esther-Sabrina Platzer ,  Matthias Wacker

发明人： Frank Deinzer ,  Esther-Sabrina Platzer ,  Matthias Wacker

IPC分类号： A61B6/00

CPC分类号： G01C1/00 ,  A61B6/481 ,  A61B6/504

摘要： The invention relates to a method and a device for determination of an optimum direction of projection or position for recording a number of two-dimensional projection images of an object of interest, with the two-dimensional projection images being recorded by rotation or translation of an imaging system around the object. Inventively the process is as follows: a) estimating a position of the object at a point in time; b) determining at least one optimum imaging view from which the optimum direction of projection and/or position is produced, for the position estimated under a) with the aid of previously determined measurement. Preferably the measurement is expressed as a function of a transformation which is described by a spatial object-imaging system relationship.

摘要翻译： 本发明涉及一种用于确定用于记录感兴趣对象的多个二维投影图像的投影或位置的最佳方向的方法和装置，其中通过旋转或平移来记录二维投影图像 成像系统周围的物体。 本发明的过程如下：a）在某个时间点估计物体的位置; b）根据先前确定的测量确定在a）下估计的位置的至少一个最佳成像视图，从该最佳成像视图产生投影和/或位置的最佳方向。 优选地，测量被表示为由空间物体成像系统关系描述的变换的函数。

公开(公告)号：US20090082990A1

公开(公告)日：2009-03-26

申请号：US12229754

申请日：2008-08-26

申请人： Frank Deinzer ,  Esther-Sabrina Platzer ,  Matthias Wacker

发明人： Frank Deinzer ,  Esther-Sabrina Platzer ,  Matthias Wacker

IPC分类号： G01C1/00

CPC分类号： G01C1/00 ,  A61B6/481 ,  A61B6/504

摘要： The invention relates to a method and a device for determination of an optimum direction of projection or position for recording a number of two-dimensional projection images of an object of interest, with the two-dimensional projection images being recorded by rotation or translation of an imaging system around the object. Inventively the process is as follows: a) estimating a position of the object at a point in time; b) determining at least one optimum imaging view from which the optimum direction of projection and/or position is produced, for the position estimated under a) with the aid of previously determined measurement. Preferably the measurement is expressed as a function of a transformation which is described by a spatial object-imaging system relationship.

摘要翻译： 本发明涉及一种用于确定用于记录感兴趣对象的多个二维投影图像的投影或位置的最佳方向的方法和装置，其中通过旋转或平移来记录二维投影图像 成像系统周围的物体。 本发明的过程如下：a）在某个时间点估计物体的位置; b）根据先前确定的测量确定在a）下估计的位置的至少一个最佳成像视图，从该最佳成像视图产生投影和/或位置的最佳方向。 优选地，测量被表示为由空间物体成像系统关系描述的变换的函数。

公开(公告)号：US20110142948A1

公开(公告)日：2011-06-16

申请号：US12941350

申请日：2010-11-08

申请人： Klaus Langer ,  Matthias Wacker ,  Beate Röder ,  Annegret Preuss ,  Volker Albrecht ,  Susanna Gräfe ,  Arno Wiehe ,  Hagen von Briesen ,  Karin Löw ,  Sylvia Wagner

发明人： Klaus Langer ,  Matthias Wacker ,  Beate Röder ,  Annegret Preuss ,  Volker Albrecht ,  Susanna Gräfe ,  Arno Wiehe ,  Hagen von Briesen ,  Karin Löw ,  Sylvia Wagner

IPC分类号： A61K31/409 ,  A61K9/00 ,  A61K9/14 ,  A61P35/00 ,  A61P17/00 ,  A61P27/02 ,  A61P13/00 ,  A61P19/02 ,  A61P29/00 ,  A61P31/04 ,  B82Y5/00

CPC分类号： A61K31/409 ,  A61K9/5169 ,  A61K41/0071

摘要： Compositions, which are stable in storage, and a method of production of pharmaceutical based nanoparticulate formulations for photodynamic therapy comprising a hydrophobic photosensitizer, human serum albumin (HSA) and stabilizing agent are provided. These nanoparticulate formulations provide therapeutically effective amounts of photosensitizer (PS) for parenteral administration. In particular, tetrapyrrole derivatives can be used as photosensitizers whose efficacy and safety are enhanced by such nanoparticulate formulations. A method of preparing the HSA-based nanoparticles under sterile conditions is also provided. In one of the preferred embodiments of the present invention temoporfin, a hydrophobic PS, is formulated as a nanoparticle for parenteral administration. The formulations are useful for treating hyperplasic and neoplasic conditions, inflammatory problems, and more specifically to target tumor cells.

摘要翻译： 提供了在储存中稳定的组合物以及用于光动力疗法的药物基纳米颗粒制剂的制备方法，其包括疏水性光敏剂，人血清白蛋白（HSA）和稳定剂。 这些纳米颗粒制剂提供用于胃肠外给药的治疗有效量的光敏剂（PS）。 特别地，四吡咯衍生物可以用作光敏剂，其功效和安全性通过这样的纳米颗粒制剂增强。 还提供了在无菌条件下制备基于HSA的纳米颗粒的方法。 在本发明的一个优选实施方案中，一种疏水性PS被配制成用于肠胃外给药的纳米颗粒。 该制剂可用于治疗过度和肿瘤状况，炎症问题，更具体地涉及靶向肿瘤细胞。

公开(公告)号：US09211283B2

公开(公告)日：2015-12-15

申请号：US12941350

申请日：2010-11-08

申请人： Klaus Langer ,  Matthias Wacker ,  Beate Röder ,  Annegret Preuss ,  Volker Albrecht ,  Susanna Gräfe ,  Arno Wiehe ,  Hagen von Briesen ,  Karin Löw ,  Sylvia Wagner

发明人： Klaus Langer ,  Matthias Wacker ,  Beate Röder ,  Annegret Preuss ,  Volker Albrecht ,  Susanna Gräfe ,  Arno Wiehe ,  Hagen von Briesen ,  Karin Löw ,  Sylvia Wagner

IPC分类号： A61K9/51 ,  A61K31/409 ,  A61K33/20 ,  A61K41/00

CPC分类号： A61K31/409 ,  A61K9/5169 ,  A61K41/0071

摘要： Compositions, which are stable in storage, and a method of production of pharmaceutical based nanoparticulate formulations for photodynamic therapy comprising a hydrophobic photosensitizer, human serum albumin (HSA) and stabilizing agent are provided. These nanoparticulate formulations provide therapeutically effective amounts of photosensitizer (PS) for parenteral administration. In particular, tetrapyrrole derivatives can be used as photosensitizers whose efficacy and safety are enhanced by such nanoparticulate formulations. A method of preparing the HSA-based nanoparticles under sterile conditions is also provided. In one of the preferred embodiments of the present invention temoporfin, a hydrophobic PS, is formulated as a nanoparticle for parenteral administration. The formulations are useful for treating hyperplasic and neoplasic conditions, inflammatory problems, and more specifically to target tumor cells.

摘要翻译： 提供了在储存中稳定的组合物以及用于光动力疗法的药物基纳米颗粒制剂的制备方法，其包括疏水性光敏剂，人血清白蛋白（HSA）和稳定剂。 这些纳米颗粒制剂提供用于胃肠外给药的治疗有效量的光敏剂（PS）。 特别地，四吡咯衍生物可以用作光敏剂，其功效和安全性通过这样的纳米颗粒制剂增强。 还提供了在无菌条件下制备基于HSA的纳米颗粒的方法。 在本发明的一个优选实施方案中，一种疏水性PS被配制成用于肠胃外给药的纳米颗粒。 该制剂可用于治疗过度和肿瘤状况，炎症问题，更具体地涉及靶向肿瘤细胞。