Assays to Identify Irreversibly Binding Inhibitors of Receptor Tyrosine Kinases
    1.
    发明申请
    Assays to Identify Irreversibly Binding Inhibitors of Receptor Tyrosine Kinases 审中-公开
    鉴定受体酪氨酸激酶不可逆结合抑制剂的方法

    公开(公告)号:US20080268460A1

    公开(公告)日:2008-10-30

    申请号:US11569288

    申请日:2005-05-11

    IPC分类号: G01N33/53

    摘要: The present invention relates to a method of identifying an inhibitor of a receptor tyrosine kinase that irreversibly binds to the kinase. Specifically, the method comprises using a variety of assays, either alone or in combination, to identify compounds that irreversibly bind to tyrosine kinases. More specifically, there are four assays, which are novel variations of a basic enzyme assay and identify irreversible binding inhibitors.

    摘要翻译: 本发明涉及鉴定不可逆地结合激酶的受体酪氨酸激酶抑制剂的方法。 具体地,该方法包括单独或组合地使用多种测定来鉴定不可逆地结合酪氨酸激酶的化合物。 更具体地,有四种测定法,其是碱性酶测定的新变体并鉴定不可逆结合抑制剂。