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公开(公告)号:US07160592B2
公开(公告)日:2007-01-09
申请号:US10366767
申请日:2003-02-14
IPC分类号: B32B1/08 , B32B27/36 , B32B15/08 , B32B15/09 , B32B27/06 , A61F2/00 , A61F2/06 , A61F2/82 , B29D23/00
CPC分类号: A61L31/10 , A61L31/16 , A61L33/0076 , A61L2300/606 , Y10T428/1352 , Y10T428/139 , Y10T428/1393 , Y10T428/31663 , Y10T428/31786 , C08L83/04 , C08L67/04
摘要: Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester on the bonded lactone. Biologically active agents may be deposited with the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.
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公开(公告)号:US20080160166A1
公开(公告)日:2008-07-03
申请号:US12049966
申请日:2008-03-17
IPC分类号: B05D3/12
CPC分类号: A61L31/10 , A61L31/16 , A61L33/0076 , A61L2300/606 , Y10T428/1352 , Y10T428/139 , Y10T428/1393 , Y10T428/31663 , Y10T428/31786 , C08L83/04 , C08L67/04
摘要: Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester on the bonded lactone. Biologically active agents may be deposited with the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.
摘要翻译: 提供涂层,其中可以通过将硅烷衍生物共价键合到金属表面来活化表面,通过原位开环聚合将内酯聚合物共价键合到硅烷衍生物上,并在粘合的内酯上沉积至少一层聚酯。 生物活性剂可以与聚酯层一起沉积。 这种涂覆的表面可用于医疗装置,特别是支架。
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公开(公告)号:US07419709B2
公开(公告)日:2008-09-02
申请号:US11605654
申请日:2006-11-28
IPC分类号: B32B1/08 , B32B27/36 , B32B15/08 , B32B15/09 , B32B27/06 , A61F2/00 , A61F2/06 , A61F2/82 , B29D23/00
CPC分类号: A61L31/10 , A61L31/16 , A61L33/0076 , A61L2300/606 , Y10T428/1352 , Y10T428/139 , Y10T428/1393 , Y10T428/31663 , Y10T428/31786 , C08L83/04 , C08L67/04
摘要: Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester on the bonded lactone. Biologically active agents may be deposited with the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.
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公开(公告)号:US07364768B2
公开(公告)日:2008-04-29
申请号:US11605634
申请日:2006-11-28
CPC分类号: A61L31/10 , A61L31/16 , A61L33/0076 , A61L2300/606 , Y10T428/1352 , Y10T428/139 , Y10T428/1393 , Y10T428/31663 , Y10T428/31786 , C08L83/04 , C08L67/04
摘要: Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester on the bonded lactone. Biologically active agents may be deposited with the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.
摘要翻译: 提供涂层,其中可以通过将硅烷衍生物共价键合到金属表面来活化表面,通过原位开环聚合将内酯聚合物共价键合到硅烷衍生物上,并在粘合的内酯上沉积至少一层聚酯。 生物活性剂可以与聚酯层一起沉积。 这种涂覆的表面可用于医疗装置,特别是支架。
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公开(公告)号:US20070071926A1
公开(公告)日:2007-03-29
申请号:US11605654
申请日:2006-11-28
IPC分类号: B32B27/08
CPC分类号: A61L31/10 , A61L31/16 , A61L33/0076 , A61L2300/606 , Y10T428/1352 , Y10T428/139 , Y10T428/1393 , Y10T428/31663 , Y10T428/31786 , C08L83/04 , C08L67/04
摘要: Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester on the bonded lactone. Biologically active agents may be deposited with the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.
摘要翻译: 提供涂层,其中可以通过将硅烷衍生物共价键合到金属表面来活化表面,通过原位开环聚合将内酯聚合物共价键合到硅烷衍生物上,并在粘合的内酯上沉积至少一层聚酯。 生物活性剂可以与聚酯层一起沉积。 这种涂覆的表面可用于医疗装置,特别是支架。
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公开(公告)号:US20070071879A1
公开(公告)日:2007-03-29
申请号:US11605634
申请日:2006-11-28
CPC分类号: A61L31/10 , A61L31/16 , A61L33/0076 , A61L2300/606 , Y10T428/1352 , Y10T428/139 , Y10T428/1393 , Y10T428/31663 , Y10T428/31786 , C08L83/04 , C08L67/04
摘要: Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester on the bonded lactone. Biologically active agents may be deposited with the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.
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公开(公告)号:US20060093771A1
公开(公告)日:2006-05-04
申请号:US11251441
申请日:2005-10-14
IPC分类号: B32B1/08
CPC分类号: A61L31/16 , A61L31/10 , A61L33/0076 , A61L2300/41 , A61L2300/416 , A61L2300/43 , A61L2300/432 , A61L2300/436 , A61L2300/608 , Y10T428/1393 , C08L67/04 , C08L83/04
摘要: Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of poly(lactide-co-caprolactone) copolymer on the bonded lactone. Biologically active agents may be disposed with the poly(lactide-co-caprolactone) copolymer layers. Such coated surfaces may be useful in medical devices, in particular stents.
摘要翻译: 提供涂层,其中可以通过将硅烷衍生物共价键合到金属表面来活化表面,通过原位开环聚合将内酯聚合物共价键合到硅烷衍生物上,并沉积至少一层聚(丙交酯 - 共 - 己内酯 )共聚物。 生物活性剂可与聚(丙交酯 - 共 - 己内酯)共聚物层一起设置。 这种涂覆的表面可用于医疗装置,特别是支架。
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