公开(公告)号：US07172603B2

公开(公告)日：2007-02-06

申请号：US10300495

申请日：2002-11-19

申请人： Fred H. Burbank ,  Michael L. Jones ,  Greig E. Altieri ,  Ed Olson

发明人： Fred H. Burbank ,  Michael L. Jones ,  Greig E. Altieri ,  Ed Olson

IPC分类号： A61B17/42

CPC分类号： A61B17/1227 ,  A61B5/026 ,  A61B8/06 ,  A61B8/12 ,  A61B17/1285 ,  A61B17/42

摘要： Devices, systems and methods for occluding blood vessels include a deployable constrictor having opposed pressure-applying portions, a delivery shaft configured to intravaginally advance the constrictor to the patient's cervix, a location sensor configured to detect a blood vessel, a deployment member for deploying the constrictor about the patient's cervix, and optionally a guide. The constrictor has a first configuration to receive a cervix and a second configuration to apply pressure to the cervical area to occlude a uterine artery by compression from the pressure-applying members. The pressure-applying members may be released from the cervix after a limited therapeutically effective time. The constrictor is for treating uterine disorders and conditions which may be treated by occlusion of the uterine arteries, such as uterine fibroids, dysfunctional uterine bleeding, post-partum hemorrhage, and bleeding associated with caesarian sections.

摘要翻译： 用于闭塞血管的装置，系统和方法包括具有相对的压力施加部分的可展开的收缩器，配置成将阴囊推进到患者的子宫颈的输送轴，配置成检测血管的位置传感器，用于部署 关于患者的子宫颈的收缩，以及可选的导引。 收缩器具有接收子宫颈的第一构造和第二构造，以通过压力从压力施加构件压迫宫颈区域以阻塞子宫动脉。 压力施加构件可在有限的治疗有效时间后从子宫颈释放。 压缩器用于治疗可通过闭塞子宫动脉（例如子宫肌瘤），功能障碍性子宫出血，产后出血以及与切片相关的出血治疗的子宫疾病和病症。

公开(公告)号：US07875036B2

公开(公告)日：2011-01-25

申请号：US11256768

申请日：2005-10-24

申请人： Fred H. Burbank ,  Greig E. Altieri ,  Michael L. Jones ,  Ed Olson

发明人： Fred H. Burbank ,  Greig E. Altieri ,  Michael L. Jones ,  Ed Olson

IPC分类号： A61B17/42

CPC分类号： A61B17/42 ,  A61B17/12 ,  A61B17/282

摘要： A method and device for treating a female patient's uterine disorder by occluding one or both of the patient's uterine artery. The treatment involves occluding one or both of the patient's uterine arteries with an intravaginal device to form a thrombus within the occluded artery or arteries and administering an agent which will prolong the occlusion of the artery or arteries after removal of the occluding device or initiate or accelerate fibroid cell apoptosis (programmed cell death). The intravaginal device has a pair of pivotally connected occluding members, with at least one of the occluding member having a movable occluding element on a distal shaft section of the occluding member.

摘要翻译： 一种用于通过闭塞患者的子宫动脉中的一者或两者来治疗女性患者的子宫疾病的方法和装置。 该治疗涉及用阴道内装置阻塞患者的子宫动脉中的一者或两者，以在闭塞的动脉或动脉内形成血栓并施用一种药剂，其将在移除闭塞装置之后延长动脉或动脉的闭塞，或启动或加速 纤维细胞凋亡（程序性细胞死亡）。 阴道内装置具有一对枢转连接的闭塞构件，其中至少一个阻塞构件在闭塞构件的远侧轴部上具有可移动的闭塞元件。

公开(公告)号：US07686817B2

公开(公告)日：2010-03-30

申请号：US10721857

申请日：2003-11-25

申请人： Fred H. Burbank ,  Greig E. Altieri ,  Michael L. Jones ,  Ed Olson

发明人： Fred H. Burbank ,  Greig E. Altieri ,  Michael L. Jones ,  Ed Olson

IPC分类号： A61B17/42

CPC分类号： A61B17/42 ,  A61B17/12 ,  A61B2017/2927 ,  A61B2017/2944 ,  A61B2017/4216 ,  A61B2017/4225

摘要： An occluding device is disclosed for occluding a female patient's uterine arteries which have unsymmetrical anatomy with respect to the patient's uterine cervix. The occluding device has a pair of pivotally connected occluding members, with at least one of the occluding member having a movable occluding element on a distal shaft section of the occluding member. The position and orientation of the occluding elements on the distal shaft sections may be adjusted by operative members on the proximal shaft sections of the occluding members to accommodate for asymmetrical uterine artery anatomy. The occluding elements have pressure applying surfaces with one or more blood flow sensors such as Doppler chips which help the physician to better identify the uterine artery and to monitor blood flow therein. A tenaculum-like guiding element configured to be secured within the patient's uterine cervix, may be provided to guide the occluding device to the patient's cervix.

摘要翻译： 公开了一种闭塞装置，用于阻塞相对于患者的子宫颈具有不对称解剖结构的女性患者的子宫动脉。 闭塞装置具有一对枢转连接的闭塞构件，其中至少一个阻塞构件在闭塞构件的远侧轴部上具有可移动的闭塞元件。 封闭元件在远侧轴部分上的位置和取向可以通过闭塞构件的近侧轴部分上的操作构件来调节，以适应不对称的子宫动脉解剖。 闭塞元件具有一个或多个血液流量传感器（例如多普勒碎片）的压力施加表面，其帮助医生更好地识别子宫动脉并监测其中的血液流动。 构造成固定在患者子宫颈内的十字形引导元件可被设置成将闭塞装置引导到病人的子宫颈。

公开(公告)号：US07479145B2

公开(公告)日：2009-01-20

申请号：US10716329

申请日：2003-11-18

申请人： Fred H. Burbank ,  Michael L. Jones ,  Greig E. Altieri ,  R. J. Serra ,  Ed Olson ,  Yu-Tung Wong

发明人： Fred H. Burbank ,  Michael L. Jones ,  Greig E. Altieri ,  R. J. Serra ,  Ed Olson ,  Yu-Tung Wong

IPC分类号： A61B17/42 ,  A61B17/46 ,  A61D1/10

CPC分类号： A61B17/4241 ,  A61B17/282 ,  A61B17/42

摘要： The invention is directed to tenaculum-like devices and systems for the intravaginal delivery of therapeutic or diagnostic devices and particularly for occluding a female patient's uterine arteries in order to treat uterine disorders. Included are methods for grasping, manipulating and retaining tissue. The tenaculum-type device has a distal portion with a sound configured to enter a cervical os without causing undue trauma or discomfort to the patient, and a retention or tissue grasping mechanism with a grasping element such as a spike configured to engage and retain a patient's cervix. The tenaculum-type devices embodying features of the invention may have an expandable distal tip to more securely be engaged within the patient's uterine cervical canal.

摘要翻译： 本发明涉及用于治疗或诊断装置的阴道内输送的特定用途的器械和系统，特别是用于阻塞女性患者的子宫动脉以治疗子宫疾病。 包括用于抓握，操纵和保持组织的方法。 所述牵引式装置具有远端部分，其具有构造成进入颈部口的声音，而不会对患者造成不适当的创伤或不适;以及保持或组织夹持机构，其具有抓握元件，例如尖峰，其构造成接合并保持患者的 宫颈。 体现本发明的特征的憩室型装置可以具有可扩张的远端，以更可靠地接合在患者的子宫颈管内。

公开(公告)号：US20060106109A1

公开(公告)日：2006-05-18

申请号：US11256768

申请日：2005-10-24

申请人： Fred Burbank ,  Greig Altieri ,  Michael Jones ,  Ed Olson

发明人： Fred Burbank ,  Greig Altieri ,  Michael Jones ,  Ed Olson

IPC分类号： A61M31/00 ,  A61K31/195 ,  A61K31/19

CPC分类号： A61B17/42 ,  A61B17/12 ,  A61B17/282

摘要： This invention is directed to a method and device for treating a female patient's uterine disorder by occluding one or both of the patient's uterine artery. The treatment embodying features of the invention basically involves occluding one or both of the patient's uterine arteries with an intravaginal device to form a thrombus within the occluded artery or arteries and administering an agent which will prolong the occlusion of the artery or arteries after removal of the occluding device or initiate or accelerate fibroid cell apoptosis (programmed cell death). The intravaginal device has a pair of pivotally connected occluding members, with at least one of the occluding member having a movable occluding element on a distal shaft section of the occluding member.

摘要翻译： 本发明涉及通过闭塞患者的子宫动脉中的一者或两者来治疗女性患者的子宫疾病的方法和装置。 体现本发明特征的治疗基本上包括用阴道内装置阻塞患者的子宫动脉中的一个或两个，以在闭塞的动脉或动脉内形成血栓，并施用一种能够在移除动脉或动脉后延长动脉或动脉闭塞的药剂 闭塞装置或引发或加速纤维细胞凋亡（程序性细胞死亡）。 阴道内装置具有一对枢转连接的闭塞构件，其中至少一个阻塞构件在闭塞构件的远侧轴部上具有可移动的闭塞元件。

公开(公告)号：US20050113634A1

公开(公告)日：2005-05-26

申请号：US10721857

申请日：2003-11-25

申请人： Fred Burbank ,  Greig Altieri ,  Michael Jones ,  Ed Olson

发明人： Fred Burbank ,  Greig Altieri ,  Michael Jones ,  Ed Olson

IPC分类号： A61B17/12 ,  A61B17/28 ,  A61B17/42 ,  A61F2/02

CPC分类号： A61B17/42 ,  A61B17/12 ,  A61B2017/2927 ,  A61B2017/2944 ,  A61B2017/4216 ,  A61B2017/4225

摘要： An occluding device is disclosed for occluding a female patient's uterine arteries which have unsymmetrical anatomy with respect to the patient's uterine cervix. The occluding device has a pair of pivotally connected occluding members, with at least one of the occluding member having a movable occluding element on a distal shaft section of the occluding member. The position and orientation of the occluding elements on the distal shaft sections may be adjusted by operative members on the proximal shaft sections of the occluding members to accommodate for asymmetrical uterine artery anatomy. The occluding elements have pressure applying surfaces with one or more blood flow sensors such as Doppler chips which help the physician to better identify the uterine artery and to monitor blood flow therein. A tenaculum-like guiding element configured to be secured within the patient's uterine cervix, may be provided to guide the occluding device to the patient's cervix.

摘要翻译： 公开了一种闭塞装置，用于阻塞相对于患者的子宫颈具有不对称解剖结构的女性患者的子宫动脉。 闭塞装置具有一对枢转连接的闭塞构件，其中至少一个阻塞构件在闭塞构件的远侧轴部上具有可移动的闭塞元件。 封闭元件在远侧轴部分上的位置和取向可以通过闭塞构件的近侧轴部分上的操作构件来调节，以适应不对称的子宫动脉解剖。 闭塞元件具有一个或多个血液流量传感器（例如多普勒碎片）的压力施加表面，其帮助医生更好地识别子宫动脉并监测其中的血液流动。 构造成固定在患者子宫颈内的十字形引导元件可被设置成将闭塞装置引导到病人的子宫颈。

公开(公告)号：US20070173863A1

公开(公告)日：2007-07-26

申请号：US11703118

申请日：2007-02-06

申请人： Fred Burbank ,  Michael Jones ,  Greig Altieri ,  Ed Olson

发明人： Fred Burbank ,  Michael Jones ,  Greig Altieri ,  Ed Olson

IPC分类号： A61B17/42

CPC分类号： A61B17/1227 ,  A61B5/026 ,  A61B8/06 ,  A61B8/12 ,  A61B17/1285 ,  A61B17/42

摘要： Devices, systems and methods for occluding blood vessels include a deployable constrictor having opposed pressure-applying portions, a delivery shaft configured to intravaginally advance the constrictor to the patient's cervix, a location sensor configured to detect a blood vessel, a deployment member for deploying the constrictor about the patient's cervix, and optionally a guide. The constrictor has a first configuration to receive a cervix and a second configuration to apply pressure to the cervical area to occlude a uterine artery by compression from the pressure-applying members. The pressure-applying members may be released from the cervix after a limited therapeutically effective time. The invention finds use in, for example, treating uterine disorders and conditions which may be treated by occlusion of the uterine arteries, such as uterine fibroids, dysfunctional uterine bleeding, post-partum hemorrhage, and bleeding associated with caesarian sections.

摘要翻译： 用于闭塞血管的装置，系统和方法包括具有相对的压力施加部分的可展开的收缩器，配置成将阴囊推进到患者的子宫颈的输送轴，配置成检测血管的位置传感器，用于部署 关于患者的子宫颈的收缩，以及可选的导引。 收缩器具有接收子宫颈的第一构造和第二构造，以通过压力从压力施加构件压迫宫颈区域以阻塞子宫动脉。 压力施加构件可在有限的治疗有效时间后从子宫颈释放。 本发明可用于例如治疗可通过闭塞子宫动脉（例如子宫肌瘤），功能障碍性子宫出血，产后出血以及与切片相关的出血治疗的子宫疾病和病症。