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![Derivatives of 5-pyridinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics](/abs-image/US/2011/01/04/US07863290B2/abs.jpg.150x150.jpg)
1.发明授权Derivatives of 5-pyridinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics 有权5-吡啶基-1-氮杂双环[3.2.1]辛烷的衍生物及其在治疗学中的应用公开(公告)号：US07863290B2
公开(公告)日：2011-01-04
申请号：US12028999
申请日：2008-02-11
申请人： Frederic Galli , Odile LeClerc , Alistair Lochead , Julien Vache
发明人： Frederic Galli , Odile LeClerc , Alistair Lochead , Julien Vache
IPC分类号： A61K31/4745 , C07D471/04
CPC分类号： C07D471/18
摘要： The invention relates to compounds having general formula (I), wherein R is as defined herein. The invention also relates to acid addition salt, a hydrate or a solvate of compounds of formula (I). The invention further relates to the method of preparing said compounds and to the use of same in therapeutics.
摘要翻译： 本发明涉及具有通式（I）的化合物，其中R如本文所定义。 本发明还涉及式（I）化合物的酸加成盐，水合物或溶剂合物。 本发明还涉及制备所述化合物的方法及其在治疗中的用途。
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![Derivatives of 5-pyridazinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics](/abs-image/US/2013/10/15/US08557819B2/abs.jpg.150x150.jpg)
公开(公告)号：US08557819B2
公开(公告)日：2013-10-15
申请号：US13286662
申请日：2011-11-01
申请人： Frederic Galli , Odile Leclerc , Alistair Lochead , Julien Vache
发明人： Frederic Galli , Odile Leclerc , Alistair Lochead , Julien Vache
IPC分类号： C07D403/04 , C07D403/14 , A61K31/503
CPC分类号： C07D471/18
摘要： The invention relates to compounds having general formula (I), wherein R is as defined herein. The invention also relates to acid addition salt, a hydrate or a solvate of compounds of formula (I). The invention further relates to the method of preparing said compounds and to the use of same in therapeutics.
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![DERIVATIVES OF 5-PYRIDAZINYL-1-AZABICYCLO[3.2.1]OCTANE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS](/abs-image/US/2009/04/02/US20090088440A1/abs.jpg.150x150.jpg)
3.发明申请DERIVATIVES OF 5-PYRIDAZINYL-1-AZABICYCLO[3.2.1]OCTANE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS 有权5-吡啶基亚氨基-1-氮杂双环[3.2.1]月桂酰胺的衍生物及其制备方法及其在治疗中的应用公开(公告)号：US20090088440A1
公开(公告)日：2009-04-02
申请号：US12328804
申请日：2008-12-05
申请人： Frederic Galli , Odile Leclerc , Alistair Lochead , Julien Vache
发明人： Frederic Galli , Odile Leclerc , Alistair Lochead , Julien Vache
IPC分类号： A61K31/501
CPC分类号： C07D471/18
摘要： The invention relates to compounds having general formula (I), wherein R is as defined herein. The invention also relates to acid addition salt, a hydrate or a solvate of compounds of formula (I). The invention further relates to the method of preparing said compounds and to the use of same in therapeutics.
摘要翻译： 本发明涉及具有通式（I）的化合物，其中R如本文所定义。 本发明还涉及式（I）化合物的酸加成盐，水合物或溶剂合物。 本发明还涉及制备所述化合物的方法及其在治疗中的用途。
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![Derivatives of 5-pyridinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics](/abs-image/US/2013/09/24/US08541440B2/abs.jpg.150x150.jpg)
4.发明授权Derivatives of 5-pyridinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics 有权5-吡啶基-1-氮杂双环[3.2.1]辛烷的衍生物及其在治疗学中的应用公开(公告)号：US08541440B2
公开(公告)日：2013-09-24
申请号：US12955389
申请日：2010-11-29
申请人： Frederic Galli , Odile Leclerc , Alistair Lochead , Julien Vache
发明人： Frederic Galli , Odile Leclerc , Alistair Lochead , Julien Vache
IPC分类号： A61K31/439 , A61P25/28 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/32 , A61P25/34 , A61P25/04
CPC分类号： C07D471/18
摘要： The invention relates to compounds having general formula (I), wherein R is as defined herein. The invention also relates to acid addition salt, a hydrate or a solvate of compounds of formula (I). The invention further relates to the method of preparing said compounds and to the use of same in therapeutics.
摘要翻译： 本发明涉及具有通式（I）的化合物，其中R如本文所定义。 本发明还涉及式（I）化合物的酸加成盐，水合物或溶剂合物。 本发明还涉及制备所述化合物的方法及其在治疗中的用途。
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![Derivatives of 5-pyridazinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics](/abs-image/US/2009/01/13/US07476674B2/abs.jpg.150x150.jpg)
5.发明授权Derivatives of 5-pyridazinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics 有权5-哒嗪基-1-氮杂双环[3.2.1]辛烷的衍生物及其在治疗学中的应用公开(公告)号：US07476674B2
公开(公告)日：2009-01-13
申请号：US12029008
申请日：2008-02-11
申请人： Frederic Galli , Odile Leclerc , Alistair Lochead , Julien Vache
发明人： Frederic Galli , Odile Leclerc , Alistair Lochead , Julien Vache
IPC分类号： C07D403/04 , C07D403/14 , A61K31/501
CPC分类号： C07D471/18
摘要： The invention relates to compounds having general formula (I), wherein R is as defined herein. The invention also relates to acid addition salt, a hydrate or a solvate of compounds of formula (I). The invention further relates to the method of preparing said compounds and to the use of same in therapeutics.
摘要翻译： 本发明涉及具有通式（I）的化合物，其中R如本文所定义。 本发明还涉及式（I）化合物的酸加成盐，水合物或溶剂合物。 本发明还涉及制备所述化合物的方法及其在治疗中的用途。
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![Derivatives of 5-pyridazinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics](/abs-image/US/2011/12/13/US08076340B2/abs.jpg.150x150.jpg)
6.发明授权Derivatives of 5-pyridazinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics 有权5-哒嗪基-1-氮杂双环[3.2.1]辛烷的衍生物及其在治疗学中的应用公开(公告)号：US08076340B2
公开(公告)日：2011-12-13
申请号：US12328804
申请日：2008-12-05
申请人： Frederic Galli , Odile Leclerc , Alistair Lochead , Julien Vache
发明人： Frederic Galli , Odile Leclerc , Alistair Lochead , Julien Vache
IPC分类号： C07D403/04 , C07D403/14 , A61K31/503
CPC分类号： C07D471/18
摘要： The invention relates to compounds having general formula (I), wherein R is as defined herein. The invention also relates to acid addition salt, a hydrate or a solvate of compounds of formula (I). The invention further relates to the method of preparing said compounds and to the use of same in therapeutics.
摘要翻译： 本发明涉及具有通式（I）的化合物，其中R如本文所定义。 本发明还涉及式（I）化合物的酸加成盐，水合物或溶剂合物。 本发明还涉及制备所述化合物的方法及其在治疗中的用途。
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7.发明授权Azabicycloalkane derivatives, preparation thereof and use thereof in therapy 有权氮杂双环烷烃衍生物，其制备方法及其在治疗中的用途公开(公告)号：US08759343B2
公开(公告)日：2014-06-24
申请号：US13422296
申请日：2012-03-16
申请人： Omar Ben Ayad , Odile LeClerc , Alistair Lochead , Mourad Saady , Franck Slowinski , Julien Vache
发明人： Omar Ben Ayad , Odile LeClerc , Alistair Lochead , Mourad Saady , Franck Slowinski , Julien Vache
IPC分类号： A61K31/4439 , C07D401/14 , C07D413/14 , C07D401/04 , A61K31/496 , A61K31/506 , A61K31/5377
CPC分类号： C07D487/08 , C07D471/08
摘要： The invention relates to compounds of the general formula (I): wherein R, m, n and o are as defined herein. The invention also relates to a method for preparing the same and to the application in therapy.
摘要翻译： 本发明涉及通式（I）的化合物：其中R，m，n和o如本文所定义。 本发明还涉及其制备方法及其在治疗中的应用。
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8.发明授权Azabicycloalkane derivatives, preparation thereof and use thereof in therapy 有权氮杂双环烷烃衍生物，其制备方法及其在治疗中的用途公开(公告)号：US08173669B2
公开(公告)日：2012-05-08
申请号：US12535156
申请日：2009-08-04
申请人： Omar Ben Ayad , Odile Leclerc , Alistair Lochead , Mourad Saady , Franck Slowinski , Julien Vache
发明人： Omar Ben Ayad , Odile Leclerc , Alistair Lochead , Mourad Saady , Franck Slowinski , Julien Vache
IPC分类号： A01N43/42 , A61K31/44 , C07D221/02
CPC分类号： C07D487/08 , C07D471/08
摘要： The invention relates to compounds of the general formula (I): Wherein R, m, n and o are as defined herein. The invention also relates to a method for preparing the same and to the application in therapy.
摘要翻译： 本发明涉及通式（I）的化合物：其中R，m，n和o如本文所定义。 本发明还涉及其制备方法及其在治疗中的应用。
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公开(公告)号：US08507470B2
公开(公告)日：2013-08-13
申请号：US12844275
申请日：2010-07-27
申请人： Aude Fayol , Alistair Lochead , Mourad Saady , Julien Vache , Philippe Yaiche
发明人： Aude Fayol , Alistair Lochead , Mourad Saady , Julien Vache , Philippe Yaiche
IPC分类号： C07D498/04
CPC分类号： C07D498/04
摘要： The disclosure relates to a series pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: wherein: Y, Z, R1, R2, R3, R4 and n are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I), intermediates therefor and their utility in treating a variety of disease conditions.
摘要翻译： 本发明涉及由式（I）表示的一系列嘧啶酮衍生物或其盐，或其溶剂合物或其水合物：其中：Y，Z，R 1，R 2，R 3，R 4和n如本公开所定义。 还公开了制备式（I）化合物，其中间体及其在治疗各种疾病状况中的用途的方法。
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公开(公告)号：US08501728B2
公开(公告)日：2013-08-06
申请号：US12844270
申请日：2010-07-27
申请人： Aude Fayol , Alistair Lochead , Mourad Saady , Julien Vache , Philippe Yaiche
发明人： Aude Fayol , Alistair Lochead , Mourad Saady , Julien Vache , Philippe Yaiche
IPC分类号： A61P3/00 , A61P25/00 , A61P35/00 , A61K31/553 , C07D498/04
CPC分类号： C07D498/04 , C07D519/00
摘要： The disclosure relates to a series pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: wherein: Y, Z, R1, R2, R3, R4 and n are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I), intermediates therefor and their utility in treating a variety of disease conditions.
摘要翻译： 本发明涉及由式（I）表示的一系列嘧啶酮衍生物或其盐，或其溶剂合物或其水合物：其中：Y，Z，R 1，R 2，R 3，R 4和n如本公开所定义。 还公开了制备式（I）化合物，其中间体及其在治疗各种疾病状况中的用途的方法。
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