-
1.发明申请Compounds and methods for reducing undesired toxicity of chemotherapeutic agents 审中-公开用于减少化学治疗剂不期望的毒性的化合物和方法公开(公告)号：US20050256055A1
公开(公告)日：2005-11-17
申请号：US10843930
申请日：2004-05-12
申请人： Frederick Hausheer , Harry Kochat , Qiuli Huang
发明人： Frederick Hausheer , Harry Kochat , Qiuli Huang
摘要： Novel compositions and formulations are disclosed that have use as toxicity-reducing agents for various chemotherapeutic agents and as treatment for certain diseases and conditions. The compositions of matter are amino acid and peptide heteroconjugated disulfides of 2-mercaptoethane sulfonate sodium.
摘要翻译： 公开了作为各种化学治疗剂的毒性还原剂和某些疾病和病症治疗的新型组合物和制剂。 物质的组成是2-巯基乙磺酸钠的氨基酸和肽杂合二硫化物。
-
公开(公告)号：US07687497B2
公开(公告)日：2010-03-30
申请号：US11974756
申请日：2007-10-16
IPC分类号： A61K31/4375 , A61K31/5377 , A61P35/00 , C07F7/10
CPC分类号： C07F7/0812 , A61K31/4375 , A61K31/5377
摘要： The novel C10-modified camptothecin analogs, and pharmaceutically-acceptable salts thereof, of the present invention: (i) possess potent antitumor activity (i.e., in nanomolar or subnanomolar concentrations) for inhibiting the growth of human and animal tumor cells in vitro; (ii) are potent inhibition of Topoisomerase I; (iii) lack of susceptibility to MDR/MRP drug resistance; (iv) require no metabolic drug activation: (v) lack glucuronidation of the A-ring or B-ring; (vi) reduce drug-binding affinity to plasma proteins; (vii) maintain lactone stability; (viii) maintain drug potency; and (ix) possess a low molecular weight (e.g., MW
摘要翻译： 本发明的新颖的C10修饰的喜树碱类似物及其药学上可接受的盐：（i）具有有效的抗肿瘤活性（即纳米摩尔或亚纳摩尔浓度），用于在体外抑制人和动物肿瘤细胞的生长; （ii）是拓扑异构酶I的有效抑制; （iii）对MDR / MRP耐药性不敏感; （iv）不需要代谢药物活化：（v）缺乏A环或B环的葡糖醛酸化; （vi）降低与血浆蛋白质的药物结合亲和力; （vii）维持内酯稳定性; （viii）维持药物效力; 和（ix）具有低分子量（例如MW <600）。
-
![Deuterated analogs of (4S)-4-Ethyl-4-hydroxy-11-[2- (trimethylsilyl)ethyl]-1H-pyrano[3', 4':6,7] indolizino [1,2-b]quinoline-3,14(4H, 12H)-dione and methods of use thereof](/abs-image/US/2012/11/08/US20120282261A1/abs.jpg.150x150.jpg)
3.发明申请Deuterated analogs of (4S)-4-Ethyl-4-hydroxy-11-[2- (trimethylsilyl)ethyl]-1H-pyrano[3', 4':6,7] indolizino [1,2-b]quinoline-3,14(4H, 12H)-dione and methods of use thereof 有权（4S）-4-乙基-4-羟基-11- [2-（三甲基甲硅烷基）乙基] -1H-吡喃并[3'，4'：6,7]中氮茚并[1,2-b] 3,4（4H，12H） - 二酮及其使用方法公开(公告)号：US20120282261A1
公开(公告)日：2012-11-08
申请号：US13068244
申请日：2011-05-06
IPC分类号： A61K31/695 , A61K31/7064 , A61K31/7076 , A61K33/24 , A61P35/02 , A61K38/43 , A61K39/395 , A61K38/02 , A61P35/00 , A61P35/04 , C07F7/10 , A61K38/22
CPC分类号： C07B59/004 , A61K38/00 , C07F7/0812
摘要： The present invention discloses: (i) two novel deuterated Karenitecin® analogs, pharmaceutically-acceptable salts, and/or derivatives thereof; (ii) methods of synthesis of said novel deuterated Karenitecin® analogs, pharmaceutically-acceptable salts, and/or derivatives thereof; (iii) pharmaceutically-acceptable formulations comprising said novel deuterated Karenitecin® analogs, pharmaceutically-acceptable salts, derivatives thereof; and/or, optionally, one or more additional chemotherapeutic agents; and (iv) methods of administration of said novel deuterated Karenitecin® analogs, pharmaceutically-acceptable salts, derivatives thereof; and/or, optionally, one or more additional chemotherapeutic agents, to subjects in need thereof.
摘要翻译： 本发明公开了：（i）两种新型氘代Karenitecin？类似物，其药学上可接受的盐和/或衍生物; （ii）合成所述新型氘化Karenitecin®类似物，其药学上可接受的盐和/或衍生物的方法; （iii）药学上可接受的制剂，其包含所述新型氘代Karenitecin？类似物，其药学上可接受的盐，衍生物; 和/或任选的一种或多种另外的化学治疗剂; 和（iv）所述新型氘化Karenitecin®类似物，其药学上可接受的盐，衍生物的给药方法; 和/或任选的一种或多种另外的化学治疗剂给予有需要的受试者。
-
公开(公告)号：US07829540B2
公开(公告)日：2010-11-09
申请号：US11985244
申请日：2007-11-14
申请人： Frederick H. Hausheer , Harry Kochat , Qiuli Huang
发明人： Frederick H. Hausheer , Harry Kochat , Qiuli Huang
IPC分类号： A61K38/05
摘要： Novel compositions and formulations are disclosed that have use as toxicity-reducing agents for various chemotherapeutic agents and as treatment for certain diseases and conditions. The compositions of matter are amino acid and peptide heteroconjugated disulfides of 2-mercaptoethane sulfonate sodium.
-
公开(公告)号：US07829538B2
公开(公告)日：2010-11-09
申请号：US11985242
申请日：2007-11-14
申请人： Frederick H. Hausheer , Harry Kochat , Qiuli Huang
发明人： Frederick H. Hausheer , Harry Kochat , Qiuli Huang
IPC分类号： A61K38/05
摘要： Novel compositions and formulations are disclosed that have use as toxicity-reducing agents for various chemotherapeutic agents and as treatment for certain diseases and conditions. The compositions of matter are amino acid and peptide heteroconjugated disulfides of 2-mercaptoethane sulfonate sodium.
-
公开(公告)号：US06977311B2
公开(公告)日：2005-12-20
申请号：US10627484
申请日：2003-07-25
申请人： Harry Kochat , Xinghai Chen , Ye Wu , Qiuli Huang , Jianyan Wang , Vincent Gerusz
发明人： Harry Kochat , Xinghai Chen , Ye Wu , Qiuli Huang , Jianyan Wang , Vincent Gerusz
IPC分类号： A61K20060101 , C07C53/00 , C07C207/00 , C07C227/22 , C07C229/00 , C07C229/24 , C07C229/30 , C07D209/46
CPC分类号： C07C227/22 , C07C229/30
摘要： A process for synthesizing substantially enantiomerically pure L-amino acids, particularly L-γ-methylene glutamic acid, and esters and salts thereof. The process includes the derivatization of (2S)-pyroglutamic acid, and the decyclization of the resulting derivative to form the desired end product.
摘要翻译： 基本上对映体纯的L-氨基酸，特别是L-γ-亚甲基谷氨酸及其酯和盐的合成方法。 该方法包括（2S） - 吡咯烷酸的衍生化，以及所得衍生物的脱环形成所需的最终产物。
-
公开(公告)号：US07829541B2
公开(公告)日：2010-11-09
申请号：US11985272
申请日：2007-11-14
申请人： Frederick H. Hausheer , Harry Kochat , Qiuli Huang
发明人： Frederick H. Hausheer , Harry Kochat , Qiuli Huang
IPC分类号： A61K38/05
摘要： Novel compositions and formulations are disclosed that have use as toxicity-reducing agents for various chemotherapeutic agents and as treatment for certain diseases and conditions. The compositions of matter are amino acid and peptide heteroconjugated disulfides of 2-mercaptoethane sulfonate sodium.
-
公开(公告)号：US07829539B2
公开(公告)日：2010-11-09
申请号：US11985243
申请日：2007-11-14
申请人： Frederick H. Hausheer , Harry Kochat , Qiuli Huang
发明人： Frederick H. Hausheer , Harry Kochat , Qiuli Huang
IPC分类号： A61K38/05
摘要： Novel compositions and formulations are disclosed that have use as toxicity-reducing agents for various chemotherapeutic agents and as treatment for certain diseases and conditions. The compositions of matter are amino acid and peptide heteroconjugated disulfides of 2-mercaptoethane sulfonate sodium.
-
公开(公告)号：US20080161416A1
公开(公告)日：2008-07-03
申请号：US11985272
申请日：2007-11-14
申请人： Frederick H. Hausheer , Harry Kochat , Qiuli Huang
发明人： Frederick H. Hausheer , Harry Kochat , Qiuli Huang
IPC分类号： A61K31/185 , A61K31/66
摘要： Novel compositions and formulations are disclosed that have use as toxicity-reducing agents for various chemotherapeutic agents and as treatment for certain diseases and conditions. The compositions of matter are amino acid and peptide heteroconjugated disulfides of 2-mercaptoethane sulfonate sodium.
-
10.发明授权Compounds and methods for reducing undesired toxicity of chemotherapeutic agents 有权用于减少化学治疗剂不期望的毒性的化合物和方法公开(公告)号：US07829117B2
公开(公告)日：2010-11-09
申请号：US11985241
申请日：2007-11-14
申请人： Frederick H. Hausheer , Harry Kochat , Qiuli Huang
发明人： Frederick H. Hausheer , Harry Kochat , Qiuli Huang
IPC分类号： A61K31/74
摘要： Novel compositions and formulations are disclosed that have use as toxicity-reducing agents for various chemotherapeutic agents and as treatment for certain diseases and conditions. The compositions of matter are amino acid and peptide heteroconjugated disulfides of 2-mercaptoethane sulfonate sodium.
摘要翻译： 公开了作为各种化学治疗剂的毒性还原剂和某些疾病和病症治疗的新型组合物和制剂。 物质的组成是2-巯基乙磺酸钠的氨基酸和肽杂合二硫化物。
-
-
-
-
-
-
-
-
-
搜索结果
34 条记录 (耗时 0.018 秒)
