公开(公告)号：US20080000828A1

公开(公告)日：2008-01-03

申请号：US10588695

申请日：2005-02-15

申请人： Friedbert Wechs ,  Arne Gehlen ,  Bodo Harten ,  Richard Kruger ,  Oliver Schuster

发明人： Friedbert Wechs ,  Arne Gehlen ,  Bodo Harten ,  Richard Kruger ,  Oliver Schuster

IPC分类号： B01D63/02 ,  B01D39/14 ,  B01D67/00 ,  B01D69/00 ,  B01D69/02 ,  B01D69/08 ,  B29C47/00 ,  B29C47/02

CPC分类号： B01D69/08 ,  B01D67/0013 ,  B01D67/0088 ,  B01D67/0095 ,  B01D67/0097 ,  B01D69/02 ,  B01D71/64 ,  B01D71/68 ,  B01D2323/02 ,  B01D2323/12 ,  B01D2323/36 ,  B01D2325/14 ,  B01D2325/20

摘要： A hydrophilic, semipermeable hollow-fibre membrane for blood treatment, with an integrally asymmetric structure based on a synthetic polymer. The hollow-fibre membrane possesses on its inner surface a porous separating layer and an open-pored supporting layer adjoining the separating layer, and has an ultrafiltration rate in albumin solution of 25 to 60 ml/(h·m2·mmHg). The hollow-fibre membrane is free from pore-stabilising additives, and has a minimum sieving coefficient for cytochrome c of 0.8 and maximum sieving coefficient for albumin of 0.005. Method for the preparation of such membranes based on coagulation induced by a non-solvent, whereby a spinning solution of a synthetic first polymer and possibly a hydrophilic second polymer is extruded into a hollow fibre through the annular slit of a hollow-fibre die with simultaneous extrusion of a coagulation medium as the interior filler through the central opening of the hollow-fibre die, the interior filler initiating coagulation in the interior of the hollow fibre as a result of which a separating layer on the inner surface of the hollow-fibre membrane is formed as well as the membrane structure, the method being characterised in that the interior filler contains a polyelectrolyte with negative fixed charges.

摘要翻译： 用于血液处理的亲水性半透性中空纤维膜，具有基于合成聚合物的整体不对称结构。 中空纤维膜在其内表面具有邻接分离层的多孔分离层和开孔支撑层，并且在白蛋白溶液中的超滤速率为25至60ml /（hm 2 / .mmHg）。 中空纤维膜不含孔稳定添加剂，细胞色素c的筛分系数最小为0.8，白蛋白筛分系数为0.005。 基于由非溶剂引起的凝结制备这种膜的方法，由此将合成的第一聚合物和可能的亲水性第二聚合物的纺丝溶液通过中空纤维模具的环形狭缝挤出成中空纤维，同时 通过中空纤维模头的中心开口挤出凝固介质作为内部填料，内部填料在中空纤维内部引发凝结，由此在中空纤维膜的内表面上形成分离层 形成膜结构，该方法的特征在于内部填充物含有具有负固定电荷的聚电解质。

公开(公告)号：US20070163949A1

公开(公告)日：2007-07-19

申请号：US10588696

申请日：2005-02-15

申请人： Friedbert Wechs ,  Arne Gehlen ,  Bodo Harten ,  Kruger Richard ,  Schuster Oliver

发明人： Friedbert Wechs ,  Arne Gehlen ,  Bodo Harten ,  Kruger Richard ,  Schuster Oliver

IPC分类号： B01D71/06

CPC分类号： B01D71/68 ,  B01D67/0011 ,  B01D67/0016 ,  B01D67/0088 ,  B01D67/0095 ,  B01D67/0097 ,  B01D69/02 ,  B01D69/08 ,  B01D2323/02 ,  B01D2323/12 ,  B01D2323/36 ,  B01D2325/14 ,  B01D2325/20 ,  Y10T428/2975

摘要： A hydrophilic semipermeable hollow-fibre membrane for blood treatment, with an integrally asymmetric structure based on a synthetic polymer. The hollow-fibre membrane possesses on its inner surface a separating layer and an adjoining open-pored supporting layer, and has an ultrafiltration rate in albumin solution of 5 to 25 ml/(h·m2·mmHg). The hollow-fibre membrane is free from pore-stabilizing additives and has a maximum sieving coefficient for albumin of 0.005 and a sieving coefficient for cytochrome c that satisfies the equation SCCC≧5·10−5·UFRAlb3−0.004·UFRAlb2+1.081·UFRAlb−0.25A method for producing such membranes by a coagulation process induced by a non-solvent, in which a spinning solution comprising a synthetic first polymer and possibly a hydrophilic second polymer is extruded through the annular slit of a hollow-fibre die to give a hollow fibre, and a coagulation medium that initiates coagulation in the interior of the hollow fibre is simultaneously extruded through the central opening of the hollow-fibre die, the coagulation medium initiating coagulation in the interior of the hollow fibre for formation of a separating layer on the inner surface of the hollow fibre and formation of the membrane structure, the method being characterized in that the interior filler contains a polyelectrolyte with negative fixed charges.

摘要翻译： 一种用于血液处理的亲水性半透性中空纤维膜，具有基于合成聚合物的整体不对称结构。 中空纤维膜的内表面具有分离层和相邻的开孔支撑层，并且在白蛋白溶液中具有5至25ml /（h.m 2 SUP·mmHg）的超滤速率。 中空纤维膜不含孔稳定添加剂，白蛋白的最大筛分系数为0.005，细胞色素c的筛分系数满足方程式<？in-line-formula description =“In-Line Formulas”end = “铅”？> SC = 5.10 。 3 3 -0.004.UFR _{Alb ^{+ 1.081.UFR -0.25 <？in-line-formula description =“In-line Formulas”end =“tail”？> 通过由非溶剂诱导的凝结过程制造这种膜的方法，其中将包含合成的第一聚合物和可能的亲水性第二聚合物的纺丝溶液通过中空纤维模头的环形狭缝挤出，得到中空纤维 ，并且在中空纤维内部引发凝结的凝固介质通过中空纤维模的中心孔同时挤出，凝固介质在中空纤维的内部起始凝结形成为 在中空纤维的内表面上形成渗透层并形成膜结构，该方法的特征在于，内部填料含有具有负固定电荷的聚电解质。}}