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公开(公告)号：US4857469A
公开(公告)日：1989-08-15
申请号：US171380
申请日：1988-03-21
CPC分类号： C12P41/005 , C12P11/00
摘要： A process for preparing an optically active mercapto compound having asymmetrical centers having the formula: ##STR1## in which R.sub.1 represents an alkyl group, R represents a hydrogen atom or an alkyl group, C* represents an asymmetric carbon, n represents the value of 1 or 2, is disclosed. The process involves the reaction of a cultured microorganism having the ability of asymmetrically hydrolyzing ester bonds of the raw material, thus eliminating the need for protecting free mercapto groups which are unstable in the reaction conditions. The optically active mercapto compound is useful as a raw material for producing a compound having medicinal effects such as antihypertensive activity.
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2.发明授权
公开(公告)号：US4727030A
公开(公告)日：1988-02-23
申请号：US791274
申请日：1985-10-25
申请人： Fumihiro Ishimura , Koji Murata , Suong-Hyu Hyon , Yoshito Ikada
发明人： Fumihiro Ishimura , Koji Murata , Suong-Hyu Hyon , Yoshito Ikada
CPC分类号： C12N11/04
摘要： A porous gel containing an immobilized enzyme is prepared by mixing an aqueous solution of polyvinyl alcohol having a saponification degree of not lower than 95 mol% and an average polymerization degree of not lower than 1,000, with an enzyme or enzyme-producing cell, and activated carbon powder, pouring the mixture into a container of any desired form, gelating and molding the mixture by dehydrating it up to a dehydration ratio of not lower than 50%, immersing the resulting molding in water, and drying the immersed molding. Preferably, dehydrating is by leaving the mixture to stand at room temperature or a temperature of from 30.degree. C. to 40.degree. C. The enzyme or enzyme-producing cell may be mixed with or adsorbed on an inorganic or organic carrier. The dried molding may be granulated.
摘要翻译： 通过将皂化度不低于95摩尔％且平均聚合度不低于1,000的聚乙烯醇水溶液与酶或酶产生细胞混合并制备含有固定化酶的多孔凝胶，并将其活化 碳粉，将混合物倒入任何所需形式的容器中，通过将其脱水至脱水率不低于50％，将混合物凝胶化和模塑，将所得模制品浸入水中，并干燥浸渍的模制品。 优选地，脱水是通过在室温或30℃至40℃的温度下使混合物静置。酶或酶产生细胞可以与无机或有机载体混合或吸附在无机或有机载体上。 干燥的成型品可以造粒。
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