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公开(公告)号：US08097635B2
公开(公告)日：2012-01-17
申请号：US12440807
申请日：2007-09-19
IPC分类号： A61K31/44
CPC分类号： A61K31/437 , A23G3/364 , A23G4/12 , A23L33/10 , A23V2002/00 , A23V2200/328 , C07D471/04 , Y10S514/866
摘要： An object of the present invention is to provide a safe and highly effective insulin resistance improving agent or therapeutic agent for type II diabetes. According to the present invention, an insulin resistance improving agent or a therapeutic agent for type II diabetes comprising a compound represented by general formula (I) (wherein R1, R2, and R3 are the same as or different from each other, and each represents lower alkyl, lower alkenyl, lower alkynyl, aralkyl, araryl, phenyl, or a hydrogen atom) or a salt thereof as an active ingredient can be provided.
摘要翻译： 本发明的目的是提供一种安全高效的胰岛素抵抗改善剂或II型糖尿病治疗剂。 根据本发明，提供一种胰岛素抵抗性改善剂或II型糖尿病治疗剂，其含有通式（I）表示的化合物（其中，R1，R2和R3彼此相同或不同，表示 低级烷基，低级烯基，低级炔基，芳烷基，芳芳基，苯基或氢原子）或其盐作为有效成分。
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公开(公告)号：US20100093780A1
公开(公告)日：2010-04-15
申请号：US12440807
申请日：2007-09-19
IPC分类号： A61K31/437 , A61P3/10
CPC分类号： A61K31/437 , A23G3/364 , A23G4/12 , A23L33/10 , A23V2002/00 , A23V2200/328 , C07D471/04 , Y10S514/866
摘要： An object of the present invention is to provide a safe and highly effective insulin resistance improving agent or therapeutic agent for type II diabetes. According to the present invention, an insulin resistance improving agent or a therapeutic agent for type II diabetes comprising a compound represented by general formula (I) (wherein R1, R2, and R3 are the same as or different from each other, and each represents lower alkyl, lower alkenyl, lower alkynyl, aralkyl, araryl, phenyl, or a hydrogen atom) or a salt thereof as an active ingredient can be provided.
摘要翻译： 本发明的目的是提供一种安全高效的胰岛素抵抗改善剂或II型糖尿病治疗剂。 根据本发明，提供一种胰岛素抵抗性改善剂或II型糖尿病治疗剂，其含有通式（I）表示的化合物（其中，R1，R2和R3彼此相同或不同，表示 低级烷基，低级烯基，低级炔基，芳烷基，芳芳基，苯基或氢原子）或其盐作为有效成分。
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公开(公告)号：US20100190815A1
公开(公告)日：2010-07-29
申请号：US12440069
申请日：2007-09-07
IPC分类号： A61K31/475
CPC分类号： C07D471/04 , A23K20/137 , A23L33/10 , A23V2002/00 , A61K31/437 , A23V2200/326
摘要： It is an objective of the present invention to provide a safe and highly effective hypertension-ameliorating agent.The present invention provides a hypertension-ameliorating agent, comprising a compound represented by general formula (I) (wherein R1, R2, and R3 are the same as or different from each other, and each represents lower alkyl, lower alkenyl, lower alkynyl, aralkyl, araryl, phenyl, or a hydrogen atom) or a salt thereof as an active ingredient.
摘要翻译： 本发明的目的是提供一种安全有效的高血压改善剂。 本发明提供一种高血压改善剂，其包含通式（I）表示的化合物（其中，R 1，R 2和R 3相同或不同，各自表示低级烷基，低级链烯基，低级炔基， 芳烷基，芳芳基，苯基或氢原子）或其盐作为活性成分。
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4.发明授权Method of preventing or ameliorating psoriasis using pyrroloquinoline quinone compounds 有权使用吡咯喹啉醌化合物预防或改善牛皮癣的方法公开(公告)号：US08575190B2
公开(公告)日：2013-11-05
申请号：US12742351
申请日：2008-11-12
IPC分类号： A61K31/44
CPC分类号： C07D471/04
摘要： The present invention provides a method for preventing or ameliorating skin psoriasis by applying as an active ingredient, a compound represented by general formula (I) or a salt thereof: (wherein R1, R2, and R3 simultaneously or separately represent a lower alkyl, lower alkenyl, lower alkynyl, aralkyl, araryl, or phenyl group, or a hydrogen atom).
摘要翻译： 本发明提供一种通过施用作为活性成分的通式（I）表示的化合物或其盐来预防或改善皮肤银屑病的方法：（其中R1，R2和R3同时或分别代表低级烷基，低级 烯基，低级炔基，芳烷基，芳芳基或苯基，或氢原子）。
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5.发明申请METHOD OF PREVENTING OR AMELIORATING PSORIASIS USING PYRROLOQUINOLINE QUINONE COMPOUNDS 有权使用吡咯啉喹啉化合物防止或增强PSORIASIS的方法公开(公告)号：US20100261749A1
公开(公告)日：2010-10-14
申请号：US12742351
申请日：2008-11-12
IPC分类号： A61K31/475 , A61P17/06
CPC分类号： C07D471/04
摘要： It is an object of the present invention to provide a safe and highly effective preventing or ameliorating agent for skin psoriasis.The present invention provides a preventing or ameliorating agent for skin psoriasis, containing, as an active ingredient, a compound represented by general formula (I) or a salt thereof: (wherein R1, R2, and R3 simultaneously or separately represent a lower alkyl, lower alkenyl, lower alkynyl, aralkyl, araryl, or phenyl group, or a hydrogen atom).
摘要翻译： 本发明的目的是提供一种安全且高效的防止或改善皮肤银屑病的药剂。 本发明提供一种皮肤银屑病的预防或改善剂，其含有通式（I）所示的化合物或其盐作为有效成分：（其中R1，R2和R3同时或分别表示低级烷基， 低级烯基，低级炔基，芳烷基，芳芳基或苯基，或氢原子）。
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公开(公告)号：US07485662B2
公开(公告)日：2009-02-03
申请号：US10549155
申请日：2004-03-19
申请人： Toshikazu Kamiya , Akio Shirai , Miho Takada , Fumiko Ogino
发明人： Toshikazu Kamiya , Akio Shirai , Miho Takada , Fumiko Ogino
CPC分类号： A61K31/401 , A23K20/142 , A23L2/52 , A23L33/175 , A23V2002/00 , A23V2250/064
摘要： An object of the present invention is to provide a therapeutic agent for diabetes mellitus or insulin resistance improving agent, or to provide foods and drinks, food and drink additives, and feeds or feed additives for treating diabetes mellitus or improving insulin diabetes.In order to achieve such an object, the present invention provides a therapeutic agent for diabetes mellitus and insulin resistance improving agent comprising hydroxyproline, a hydroxyproline derivative or a pharmaceutically acceptable salt thereof or foods and drinks, food and drink additives, feeds or feed additives for treatment of diabetes mellitus or improvement of insulin resistance comprising the same.
摘要翻译： 本发明的目的是提供糖尿病或胰岛素抵抗性改善剂的治疗剂，或提供食品和饮料，食品和饮料添加剂以及用于治疗糖尿病或改善胰岛素糖尿病的饲料或饲料添加剂。 为了达到上述目的，本发明提供了含有羟脯氨酸，羟脯氨酸衍生物或其药学上可接受的盐或食品和饮料的糖尿病和胰岛素抵抗改善剂的治疗剂，食品和饮料添加剂，饲料添加剂或饲料添加剂 糖尿病的治疗或胰岛素抵抗的改善包括它们。
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公开(公告)号：US20060173066A1
公开(公告)日：2006-08-03
申请号：US10549155
申请日：2004-03-19
申请人： Toshikazu Kamiya , Akio Shirai , Miho Takada , Fumiko Ogino
发明人： Toshikazu Kamiya , Akio Shirai , Miho Takada , Fumiko Ogino
IPC分类号： A61K31/4015
CPC分类号： A61K31/401 , A23K20/142 , A23L2/52 , A23L33/175 , A23V2002/00 , A23V2250/064
摘要： An object of the present invention is to provide a therapeutic agent for diabetes mellitus or insulin resistance improving agent, or to provide foods and drinks, food and drink additives, and feeds or feed additives for treating diabetes mellitus or improving insulin diabetes. In order to achieve such an object, the present invention provides a therapeutic agent for diabetes mellitus and insulin resistance improving agent comprising hydroxyproline, a hydroxyproline derivative or a pharmaceutically acceptable salt thereof or foods and drinks, food and drink additives, feeds or feed additives for treatment of diabetes mellitus or improvement of insulin resistance comprising the same.
摘要翻译： 本发明的目的是提供糖尿病或胰岛素抵抗性改善剂的治疗剂，或提供食品和饮料，食品和饮料添加剂，以及用于治疗糖尿病或改善胰岛素糖尿病的饲料或饲料添加剂。 为了达到上述目的，本发明提供了含有羟脯氨酸，羟脯氨酸衍生物或其药学上可接受的盐或食品和饮料的糖尿病和胰岛素抵抗改善剂的治疗剂，食品和饮料添加剂，饲料添加剂或饲料添加剂 糖尿病的治疗或胰岛素抵抗的改善包括它们。
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公开(公告)号：US20100040715A1
公开(公告)日：2010-02-18
申请号：US12519190
申请日：2007-12-14
申请人： Toshikazu Kamiya , Shun Kayahashi , Akio Shirai
发明人： Toshikazu Kamiya , Shun Kayahashi , Akio Shirai
IPC分类号： A61K36/00
CPC分类号： A61K36/07 , A61K31/198
摘要： The invention provides a composition containing a fruit body of Agaricus blazei murill or an extract of the fruit body, and an amino acid constituting the ornithine cycle or a salt thereof, wherein the pharmacological activities of the fruit body of Agaricus blazei murill or the extract of the fruit body and the amino acid constituting the omithine cycle or the salt thereof are increased synergistically. Such a composition can contain a fruit body of Agaricus blazei murill or an extract of the fruit body, and an amino acid constituting the ornithine cycle or a salt thereof in 10-100 parts by weight per 1 part by weight of the fruit body or the extract.
摘要翻译： 本发明提供一种含有姬松茸的水果体或果实的提取物的组合物和构成鸟氨酸循环的氨基酸或其盐，其中，姬松茸蕈果实果实的药理活性或提取物 水果体和构成奥米星循环的氨基酸或其盐的协同增加。 这种组合物可以含有10-100重量份的每1重量份水果体或果实体的水果体的果实体或果实的提取物，以及构成鸟氨酸循环的氨基酸或其盐 提取。
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9.发明授权Anomaly judgment system for operator detection device and process for judging normality/anomaly of operator detection device 有权用于操作员检测装置的异常判断系统和用于判断操作员检测装置的正常/异常的过程公开(公告)号：US07456730B2
公开(公告)日：2008-11-25
申请号：US11302588
申请日：2005-12-13
IPC分类号： B60Q1/00
CPC分类号： B60N2/002 , B60K28/04 , B60N2/0244 , B60R21/01524 , B60R21/01546 , B60R2021/0079 , B60R2021/01184
摘要： An anomaly judgment system includes an actuating switch and an anomaly judgment unit for judging anomaly of an operator detection device that is turned into an ON state when detecting an operator in a vehicle. The actuating switch is operable to be turned into an ON state by the operator. The anomaly judgment unit judges the operator detection device as anomalous when a time period during which the actuating switch is in an OFF state with the operator detection device in the ON state exceeds a predetermined time period.
摘要翻译： 异常判断系统包括：动作开关和异常判定单元，用于判断在车辆中检测到操作者时变为ON状态的操作者检测装置的异常。 致动开关可操作以由操作者变为ON状态。 当操作者检测装置处于接通状态的启动开关处于断开状态的时间段超过预定时间段时，异常判断单元判断操作者检测装置是异常的。
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公开(公告)号：US20060127492A1
公开(公告)日：2006-06-15
申请号：US10537401
申请日：2003-12-02
申请人： Hiroshi Tsuchita , Masato Saito , Toshikazu Kamiya , Miho Komatsu
发明人： Hiroshi Tsuchita , Masato Saito , Toshikazu Kamiya , Miho Komatsu
IPC分类号： A61K35/20 , A61K31/198
CPC分类号： A61K31/198 , A23L2/66 , A23L33/175 , A23L33/19 , A23V2002/00 , A61K38/018 , A61K38/1709 , A61K2300/00 , A23V2250/54252 , A23V2250/0628 , A23V2250/0626 , A23V2250/0654 , A23V2250/062
摘要： A long-acting improver of muscular fatigue characterized by comprising 4 kinds of amino acids made up of leucine, isoleucine, valine and glutamine, and a whey protein component (whey protein and/or decomposition product of whey protein). At least one of a whey protein isolate (WPI), a whey protein concentrate (WPC), β-lactoglobulin, and α-lactalbumin is used as the whey protein. Novel food or drink, and pharmaceuticals which exhibit sustained recovery effects on muscular fatigue are provided.
摘要翻译： 一种长效肌肉疲劳改善剂，其特征在于包含由亮氨酸，异亮氨酸，缬氨酸和谷氨酰胺组成的4种氨基酸和乳清蛋白组分（乳清蛋白和/或乳清蛋白的分解产物）。 使用乳清蛋白分离物（WPI），乳清蛋白浓缩物（WPC），β-乳球蛋白和α-乳白蛋白中的至少一种作为乳清蛋白。 提供新的食物或饮料以及对肌肉疲劳具有持续恢复作用的药物。
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