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    1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF
    3.
    发明申请
    1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF 有权
    1,3-苯并噻嗪酮衍生物及其用途

    公开(公告)号：US20090082343A1

    公开(公告)日：2009-03-26

    申请号：US12099779

    申请日：2008-04-08

    申请人： Masahiro Kajino ,  Yutaka Nakayama ,  Akira Kawada ,  Haruhide Kimura ,  Taisuke Tawaraishi

    发明人： Masahiro Kajino ,  Yutaka Nakayama ,  Akira Kawada ,  Haruhide Kimura ,  Taisuke Tawaraishi

    IPC分类号： A61K31/5415 ,  C07D401/04 ,  A61P9/00 ,  A61P1/00

    CPC分类号： C07D417/04 ,  A61K31/5415 ,  C07D417/14

    摘要： This invention provides a compound represented by the formula (I): wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents; R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I), which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

    摘要翻译： 本发明提供由式（I）表示的化合物：其中R1是氢原子，卤素原子，羟基，硝基，任选卤代烷基，任选具有取代基的烷氧基，任选具有取代基的酰基或氨基; R 2是可以具有取代基的吡啶基，呋喃基，噻吩基，吡咯基，喹啉基，吡嗪基，嘧啶基，哒嗪基，吲哚基，四氢喹啉基或噻唑基。 n为1或2; 或盐。 本发明提供了一种安全药物，其包含具有优异的细胞凋亡抑制作用和MIF结合作用的式（I）化合物，用于预防和/或治疗心脏病，神经退行性疾病，脑血管病，中枢神经感染性疾病， 外伤，脱髓鞘疾病，骨和关节疾病，肾脏疾病，肝病，骨发育不良，艾滋病，癌症等。

    1,3-benzothiazinone derivatives and use thereof
    4.
    发明授权
    1,3-benzothiazinone derivatives and use thereof 有权
    1,3-苯并噻嗪酮衍生物及其用途

    公开(公告)号：US07767665B2

    公开(公告)日：2010-08-03

    申请号：US12099779

    申请日：2008-04-08

    申请人： Masahiro Kajino ,  Yutaka Nakayama ,  Akira Kawada ,  Haruhide Kimura ,  Taisuke Tawaraishi

    发明人： Masahiro Kajino ,  Yutaka Nakayama ,  Akira Kawada ,  Haruhide Kimura ,  Taisuke Tawaraishi

    IPC分类号： C07D417/04 ,  A61K31/538

    CPC分类号： C07D417/04 ,  A61K31/5415 ,  C07D417/14

    摘要： This invention provides a compound represented by the formula (I): wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents; R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I), which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

    摘要翻译： 本发明提供由式（I）表示的化合物：其中R1是氢原子，卤素原子，羟基，硝基，任选卤代烷基，任选具有取代基的烷氧基，任选具有取代基的酰基或氨基; R 2是可以具有取代基的吡啶基，呋喃基，噻吩基，吡咯基，喹啉基，吡嗪基，嘧啶基，哒嗪基，吲哚基，四氢喹啉基或噻唑基。 n为1或2; 或盐。 本发明提供一种安全药物，其包含具有优异的细胞凋亡抑制作用和MIF结合作用的式（I）化合物，用于预防和/或治疗心脏病，神经退行性疾病，脑血管病，中枢神经感染性疾病， 外伤，脱髓鞘疾病，骨和关节疾病，肾脏疾病，肝病，骨发育不良，艾滋病，癌症等。

    1, 3-benzothiazinone derivatives and use thereof
    5.
    发明授权
    1, 3-benzothiazinone derivatives and use thereof 有权
    1,3-苯并噻嗪酮衍生物及其用途

    公开(公告)号：US07399759B2

    公开(公告)日：2008-07-15

    申请号：US10488384

    申请日：2002-09-02

    申请人： Masahiro Kajino ,  Akira Kawada ,  Yutaka Nakayama ,  Haruhide Kimura ,  Taisuke Tawaraishi

    发明人： Masahiro Kajino ,  Akira Kawada ,  Yutaka Nakayama ,  Haruhide Kimura ,  Taisuke Tawaraishi

    IPC分类号： C07D417/04 ,  A61K31/538

    CPC分类号： C07D417/04 ,  A61K31/5415 ,  C07D417/14

    摘要： This invention provides a compound represented by the formula (I): wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents; R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I), which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

    摘要翻译： 本发明提供由式（I）表示的化合物：其中R 1是氢原子，卤素原子，羟基，硝基，任选卤代烷基，任选具有取代基的烷氧基，任选具有 取代基; R 2是吡啶基，呋喃基，噻吩基，吡咯基，喹啉基，吡嗪基，嘧啶基，哒嗪基，吲哚基，四氢喹啉基或噻唑基，它们各自可以具有取代基; n为1或2; 或盐。 本发明提供了一种安全药物，其包含具有优异的细胞凋亡抑制作用和MIF结合作用的式（I）化合物，用于预防和/或治疗心脏病，神经退行性疾病，脑血管病，中枢神经感染性疾病， 外伤，脱髓鞘疾病，骨和关节疾病，肾脏疾病，肝病，骨发育不良，艾滋病，癌症等。