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    1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF
    1.
    发明申请
    1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF 有权
    1,3-苯并噻嗪酮衍生物及其用途

    公开(公告)号：US20090082343A1

    公开(公告)日：2009-03-26

    申请号：US12099779

    申请日：2008-04-08

    申请人： Masahiro Kajino ,  Yutaka Nakayama ,  Akira Kawada ,  Haruhide Kimura ,  Taisuke Tawaraishi

    发明人： Masahiro Kajino ,  Yutaka Nakayama ,  Akira Kawada ,  Haruhide Kimura ,  Taisuke Tawaraishi

    IPC分类号： A61K31/5415 ,  C07D401/04 ,  A61P9/00 ,  A61P1/00

    CPC分类号： C07D417/04 ,  A61K31/5415 ,  C07D417/14

    摘要： This invention provides a compound represented by the formula (I): wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents; R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I), which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

    摘要翻译： 本发明提供由式（I）表示的化合物：其中R1是氢原子，卤素原子，羟基，硝基，任选卤代烷基，任选具有取代基的烷氧基，任选具有取代基的酰基或氨基; R 2是可以具有取代基的吡啶基，呋喃基，噻吩基，吡咯基，喹啉基，吡嗪基，嘧啶基，哒嗪基，吲哚基，四氢喹啉基或噻唑基。 n为1或2; 或盐。 本发明提供了一种安全药物，其包含具有优异的细胞凋亡抑制作用和MIF结合作用的式（I）化合物，用于预防和/或治疗心脏病，神经退行性疾病，脑血管病，中枢神经感染性疾病， 外伤，脱髓鞘疾病，骨和关节疾病，肾脏疾病，肝病，骨发育不良，艾滋病，癌症等。

    1,3-benzothiazinone derivatives and use thereof
    2.
    发明授权
    1,3-benzothiazinone derivatives and use thereof 有权
    1,3-苯并噻嗪酮衍生物及其用途

    公开(公告)号：US07767665B2

    公开(公告)日：2010-08-03

    申请号：US12099779

    申请日：2008-04-08

    申请人： Masahiro Kajino ,  Yutaka Nakayama ,  Akira Kawada ,  Haruhide Kimura ,  Taisuke Tawaraishi

    发明人： Masahiro Kajino ,  Yutaka Nakayama ,  Akira Kawada ,  Haruhide Kimura ,  Taisuke Tawaraishi

    IPC分类号： C07D417/04 ,  A61K31/538

    CPC分类号： C07D417/04 ,  A61K31/5415 ,  C07D417/14

    摘要： This invention provides a compound represented by the formula (I): wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents; R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I), which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

    摘要翻译： 本发明提供由式（I）表示的化合物：其中R1是氢原子，卤素原子，羟基，硝基，任选卤代烷基，任选具有取代基的烷氧基，任选具有取代基的酰基或氨基; R 2是可以具有取代基的吡啶基，呋喃基，噻吩基，吡咯基，喹啉基，吡嗪基，嘧啶基，哒嗪基，吲哚基，四氢喹啉基或噻唑基。 n为1或2; 或盐。 本发明提供一种安全药物，其包含具有优异的细胞凋亡抑制作用和MIF结合作用的式（I）化合物，用于预防和/或治疗心脏病，神经退行性疾病，脑血管病，中枢神经感染性疾病， 外伤，脱髓鞘疾病，骨和关节疾病，肾脏疾病，肝病，骨发育不良，艾滋病，癌症等。

    1, 3-benzothiazinone derivatives and use thereof
    3.
    发明授权
    1, 3-benzothiazinone derivatives and use thereof 有权
    1,3-苯并噻嗪酮衍生物及其用途

    公开(公告)号：US07399759B2

    公开(公告)日：2008-07-15

    申请号：US10488384

    申请日：2002-09-02

    申请人： Masahiro Kajino ,  Akira Kawada ,  Yutaka Nakayama ,  Haruhide Kimura ,  Taisuke Tawaraishi

    发明人： Masahiro Kajino ,  Akira Kawada ,  Yutaka Nakayama ,  Haruhide Kimura ,  Taisuke Tawaraishi

    IPC分类号： C07D417/04 ,  A61K31/538

    CPC分类号： C07D417/04 ,  A61K31/5415 ,  C07D417/14

    摘要： This invention provides a compound represented by the formula (I): wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents; R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I), which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

    摘要翻译： 本发明提供由式（I）表示的化合物：其中R 1是氢原子，卤素原子，羟基，硝基，任选卤代烷基，任选具有取代基的烷氧基，任选具有 取代基; R 2是吡啶基，呋喃基，噻吩基，吡咯基，喹啉基，吡嗪基，嘧啶基，哒嗪基，吲哚基，四氢喹啉基或噻唑基，它们各自可以具有取代基; n为1或2; 或盐。 本发明提供了一种安全药物，其包含具有优异的细胞凋亡抑制作用和MIF结合作用的式（I）化合物，用于预防和/或治疗心脏病，神经退行性疾病，脑血管病，中枢神经感染性疾病， 外伤，脱髓鞘疾病，骨和关节疾病，肾脏疾病，肝病，骨发育不良，艾滋病，癌症等。

    1, 3-benzothiazinone derivatives and use thereof
    4.
    发明申请
    1, 3-benzothiazinone derivatives and use thereof 有权
    1,3-苯并噻嗪酮衍生物及其用途

    公开(公告)号：US20050032786A1

    公开(公告)日：2005-02-10

    申请号：US10488384

    申请日：2002-09-02

    申请人： Masahiro Kajino ,  Akira Kawada ,  Yutaka Nakayama ,  Haruhide Kimura

    发明人： Masahiro Kajino ,  Akira Kawada ,  Yutaka Nakayama ,  Haruhide Kimura

    IPC分类号： A61K31/5415 ,  A61P1/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P13/12 ,  A61P17/00 ,  A61P19/00 ,  A61P19/02 ,  A61P25/00 ,  A61P31/00 ,  A61P43/00 ,  C07D417/04 ,  C07D417/14 ,  C07D279/16

    CPC分类号： C07D417/04 ,  A61K31/5415 ,  C07D417/14

    摘要： This invention provides a compound represented by the formula (I): wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents; R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I), which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

    摘要翻译： 本发明提供由式（I）表示的化合物：其中R 1为氢原子，卤素原子，羟基，硝基，任选卤代烷基，任选具有取代基的烷氧基，任选具有取代基的酰基或氨基; R 2是吡啶基，呋喃基，噻吩基，吡咯基，喹啉基，吡嗪基，嘧啶基，哒嗪基，吲哚基，四氢喹啉基或噻唑基，其各自可以具有取代基; n为1或2; 或盐。 本发明提供一种安全药物，其包含具有优异的细胞凋亡抑制作用和MIF结合作用的式（I）化合物，用于预防和/或治疗心脏病，神经退行性疾病，脑血管病，中枢神经感染性疾病， 外伤，脱髓鞘疾病，骨和关节疾病，肾脏疾病，肝病，骨发育不良，艾滋病，癌症等。

    Optical fiber having glass core and fluoro-copolymer cladding
    9.
    发明授权
    Optical fiber having glass core and fluoro-copolymer cladding 失效
    具有玻璃芯和氟共聚物包层的光纤

    公开(公告)号：US4787709A

    公开(公告)日：1988-11-29

    申请号：US826588

    申请日：1986-02-06

    申请人： Akira Kawada ,  Takashi Yasumura ,  Toshio Koishi

    发明人： Akira Kawada ,  Takashi Yasumura ,  Toshio Koishi

    IPC分类号： G02B1/04 ,  C03C13/04 ,  C03C25/10 ,  C08L73/00 ,  G02B6/00 ,  G02B6/02 ,  G02B6/16

    CPC分类号： C03C25/105 ,  C03C13/04 ,  G02B6/02033 ,  Y10T428/2962

    摘要： The invention relates to an optical fiber of the step-index type using quartz glass or an inorganic optical glass as the core material and a fluorine-containing resin as the cladding material. A copolymer of vinylidene fluoride with hexafluoroacetone, preferably at a molar ratio in the range from 96:4 to 88:12, is employed as the cladding material. Using such a copolymer, a highly transparent and very strong and tough cladding layer can easily be formed by a solution coating method.

    摘要翻译： 本发明涉及使用石英玻璃或无机光学玻璃作为芯材的分级折射型光纤，含氟树脂作为包层材料。 偏二氟乙烯与六氟丙酮的共聚物优选以96:4至88:12的摩尔比进行包覆材料。 使用这样的共聚物，可以通过溶液涂布法容易地形成高度透明且非常坚固和坚韧的包层。

    Fluorine-containing resin composition for optical use
    10.
    发明授权
    Fluorine-containing resin composition for optical use 失效
    用于光学用途的含氟树脂组合物

    公开(公告)号：US4617350A

    公开(公告)日：1986-10-14

    申请号：US826373

    申请日：1986-02-05

    申请人： Kazuhiko Maeda ,  Akira Kawada

    发明人： Kazuhiko Maeda ,  Akira Kawada

    IPC分类号： C08L33/00 ,  C08L1/00 ,  C08L27/00 ,  C08L27/12 ,  C08L27/14 ,  C08L27/16 ,  C08L27/20 ,  C08L33/02 ,  C08L33/04 ,  C08L33/08

    CPC分类号： C08L27/16 ,  C08L33/08

    摘要： A thermoplastic resin composition useful for optical purposes is obtained by blending a polymer of an acrylic ester with a copolymer of vinylidene fluoride (VDF) and hexafluoroacetone (HFA). The blending ratio is not limited, though very good transparency is ensured when the acrylic ester polymer amounts to at least 20 wt %. It is preferable to use a polymer of an acrylic ester with an alkyl alcohol having not more than 4 carbon atoms. When using the resin composition in optical fibers or cylindrical lenses it is suitable to use a VDF/HFA copolymer containing not more than 20 mol % of HFA. The refractive index of a member formed of the resin composition is lower than that of the acrylic ester polymer and falls in the range of about 1.37-1.48. The resin composition is soluble in various organic solvents and accordingly can be used for adhesing and coating purposes too. Besides, this resin composition serves as a thermochromic material.

    摘要翻译： 通过将丙烯酸酯的聚合物与偏二氟乙烯（VDF）和六氟丙酮（HFA）的共聚物共混而获得用于光学目的的热塑性树脂组合物。 共混比没有限制，但是当丙烯酸酯聚合物达到至少20重量％时，确保了非常好的透明度。 优选使用具有不超过4个碳原子的烷基醇的丙烯酸酯的聚合物。 当将光学纤维或圆柱形透镜中的树脂组合物使用时，适合使用含有不大于20mol％HFA的VDF / HFA共聚物。 由树脂组合物形成的部件的折射率低于丙烯酸酯聚合物的折射率，并且在约1.37-1.48的范围内。 树脂组合物可溶于各种有机溶剂，因此也可用于粘合和涂布。 此外，该树脂组合物用作热变色材料。