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    1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF
    1.
    发明申请
    1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF 有权
    1,3-苯并噻嗪酮衍生物及其用途

    公开(公告)号：US20090082343A1

    公开(公告)日：2009-03-26

    申请号：US12099779

    申请日：2008-04-08

    申请人： Masahiro Kajino ,  Yutaka Nakayama ,  Akira Kawada ,  Haruhide Kimura ,  Taisuke Tawaraishi

    发明人： Masahiro Kajino ,  Yutaka Nakayama ,  Akira Kawada ,  Haruhide Kimura ,  Taisuke Tawaraishi

    IPC分类号： A61K31/5415 ,  C07D401/04 ,  A61P9/00 ,  A61P1/00

    CPC分类号： C07D417/04 ,  A61K31/5415 ,  C07D417/14

    摘要： This invention provides a compound represented by the formula (I): wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents; R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I), which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

    摘要翻译： 本发明提供由式（I）表示的化合物：其中R1是氢原子，卤素原子，羟基，硝基，任选卤代烷基，任选具有取代基的烷氧基，任选具有取代基的酰基或氨基; R 2是可以具有取代基的吡啶基，呋喃基，噻吩基，吡咯基，喹啉基，吡嗪基，嘧啶基，哒嗪基，吲哚基，四氢喹啉基或噻唑基。 n为1或2; 或盐。 本发明提供了一种安全药物，其包含具有优异的细胞凋亡抑制作用和MIF结合作用的式（I）化合物，用于预防和/或治疗心脏病，神经退行性疾病，脑血管病，中枢神经感染性疾病， 外伤，脱髓鞘疾病，骨和关节疾病，肾脏疾病，肝病，骨发育不良，艾滋病，癌症等。

    1,3-benzothiazinone derivatives and use thereof
    2.
    发明授权
    1,3-benzothiazinone derivatives and use thereof 有权
    1,3-苯并噻嗪酮衍生物及其用途

    公开(公告)号：US07767665B2

    公开(公告)日：2010-08-03

    申请号：US12099779

    申请日：2008-04-08

    申请人： Masahiro Kajino ,  Yutaka Nakayama ,  Akira Kawada ,  Haruhide Kimura ,  Taisuke Tawaraishi

    发明人： Masahiro Kajino ,  Yutaka Nakayama ,  Akira Kawada ,  Haruhide Kimura ,  Taisuke Tawaraishi

    IPC分类号： C07D417/04 ,  A61K31/538

    CPC分类号： C07D417/04 ,  A61K31/5415 ,  C07D417/14

    摘要： This invention provides a compound represented by the formula (I): wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents; R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I), which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

    摘要翻译： 本发明提供由式（I）表示的化合物：其中R1是氢原子，卤素原子，羟基，硝基，任选卤代烷基，任选具有取代基的烷氧基，任选具有取代基的酰基或氨基; R 2是可以具有取代基的吡啶基，呋喃基，噻吩基，吡咯基，喹啉基，吡嗪基，嘧啶基，哒嗪基，吲哚基，四氢喹啉基或噻唑基。 n为1或2; 或盐。 本发明提供一种安全药物，其包含具有优异的细胞凋亡抑制作用和MIF结合作用的式（I）化合物，用于预防和/或治疗心脏病，神经退行性疾病，脑血管病，中枢神经感染性疾病， 外伤，脱髓鞘疾病，骨和关节疾病，肾脏疾病，肝病，骨发育不良，艾滋病，癌症等。

    1, 3-benzothiazinone derivatives and use thereof
    3.
    发明授权
    1, 3-benzothiazinone derivatives and use thereof 有权
    1,3-苯并噻嗪酮衍生物及其用途

    公开(公告)号：US07399759B2

    公开(公告)日：2008-07-15

    申请号：US10488384

    申请日：2002-09-02

    申请人： Masahiro Kajino ,  Akira Kawada ,  Yutaka Nakayama ,  Haruhide Kimura ,  Taisuke Tawaraishi

    发明人： Masahiro Kajino ,  Akira Kawada ,  Yutaka Nakayama ,  Haruhide Kimura ,  Taisuke Tawaraishi

    IPC分类号： C07D417/04 ,  A61K31/538

    CPC分类号： C07D417/04 ,  A61K31/5415 ,  C07D417/14

    摘要： This invention provides a compound represented by the formula (I): wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents; R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I), which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

    摘要翻译： 本发明提供由式（I）表示的化合物：其中R 1是氢原子，卤素原子，羟基，硝基，任选卤代烷基，任选具有取代基的烷氧基，任选具有 取代基; R 2是吡啶基，呋喃基，噻吩基，吡咯基，喹啉基，吡嗪基，嘧啶基，哒嗪基，吲哚基，四氢喹啉基或噻唑基，它们各自可以具有取代基; n为1或2; 或盐。 本发明提供了一种安全药物，其包含具有优异的细胞凋亡抑制作用和MIF结合作用的式（I）化合物，用于预防和/或治疗心脏病，神经退行性疾病，脑血管病，中枢神经感染性疾病， 外伤，脱髓鞘疾病，骨和关节疾病，肾脏疾病，肝病，骨发育不良，艾滋病，癌症等。

    1, 3-benzothiazinone derivatives and use thereof
    4.
    发明申请
    1, 3-benzothiazinone derivatives and use thereof 有权
    1,3-苯并噻嗪酮衍生物及其用途

    公开(公告)号：US20050032786A1

    公开(公告)日：2005-02-10

    申请号：US10488384

    申请日：2002-09-02

    申请人： Masahiro Kajino ,  Akira Kawada ,  Yutaka Nakayama ,  Haruhide Kimura

    发明人： Masahiro Kajino ,  Akira Kawada ,  Yutaka Nakayama ,  Haruhide Kimura

    IPC分类号： A61K31/5415 ,  A61P1/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P13/12 ,  A61P17/00 ,  A61P19/00 ,  A61P19/02 ,  A61P25/00 ,  A61P31/00 ,  A61P43/00 ,  C07D417/04 ,  C07D417/14 ,  C07D279/16

    CPC分类号： C07D417/04 ,  A61K31/5415 ,  C07D417/14

    摘要： This invention provides a compound represented by the formula (I): wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents; R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I), which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

    摘要翻译： 本发明提供由式（I）表示的化合物：其中R 1为氢原子，卤素原子，羟基，硝基，任选卤代烷基，任选具有取代基的烷氧基，任选具有取代基的酰基或氨基; R 2是吡啶基，呋喃基，噻吩基，吡咯基，喹啉基，吡嗪基，嘧啶基，哒嗪基，吲哚基，四氢喹啉基或噻唑基，其各自可以具有取代基; n为1或2; 或盐。 本发明提供一种安全药物，其包含具有优异的细胞凋亡抑制作用和MIF结合作用的式（I）化合物，用于预防和/或治疗心脏病，神经退行性疾病，脑血管病，中枢神经感染性疾病， 外伤，脱髓鞘疾病，骨和关节疾病，肾脏疾病，肝病，骨发育不良，艾滋病，癌症等。

    1,3-Benzothiazinone derivatives, process for producing the same use thereof
    5.
    发明授权
    1,3-Benzothiazinone derivatives, process for producing the same use thereof 失效
    1,3-苯并噻嗪酮衍生物，其制备方法相同

    公开(公告)号：US07659267B2

    公开(公告)日：2010-02-09

    申请号：US10537520

    申请日：2003-12-04

    申请人： Masahiro Kajino ,  Yutaka Nakayama ,  Haruhide Kimura

    发明人： Masahiro Kajino ,  Yutaka Nakayama ,  Haruhide Kimura

    IPC分类号： C07D279/16 ,  A61K31/5415

    CPC分类号： C07D263/58 ,  A61K31/5415 ,  C07D279/08

    摘要： As prophylactic and/or therapeutic agents for cardiovascular diseases, bone or joint diseases, infectious diseases, inflammatory diseases, kidney diseases, etc. having safe and excellent effects of cell death inhibition, MIF binding, etc., there are provided compounds represented by formula: [wherein, R1 represents a halogen atom, etc., R2 represents a group represented by formula: (wherein, R3 represents hydrogen atom, an optionally substituted alkoxy, etc., R4 represents hydrogen atom, bromine atom, cyano, etc., R5 represents hydrogen atom, hydroxy, etc., R6 represents hydrogen atom, etc., R7 represents hydrogen atom, etc.) etc., and n represents an integer of 0 to 4] or salts thereof.

    摘要翻译： 作为具有安全且优异的细胞死亡抑制作用，MIF结合等的心血管疾病，骨或关节疾病，感染性疾病，炎性疾病，肾脏疾病等的预防和/或治疗剂，提供了式 [其中，R1表示卤素原子等，R2表示由式（其中R3表示氢原子，任选取代的烷氧基等，R4表示氢原子，溴原子，氰基等）表示的基团， R5表示氢原子，羟基等，R6表示氢原子等，R7表示氢原子等）等，n表示0〜4的整数]或其盐。

    1,3-Benzothiazinone derivatives, process for producing the same and use thereof
    6.
    发明申请
    1,3-Benzothiazinone derivatives, process for producing the same and use thereof 失效
    1,3-苯并噻嗪酮衍生物，其制备方法及其用途

    公开(公告)号：US20060052371A1

    公开(公告)日：2006-03-09

    申请号：US10537520

    申请日：2003-12-04

    申请人： Masahiro Kajino ,  Yutaka Nakayama ,  Haruhide Kimura

    发明人： Masahiro Kajino ,  Yutaka Nakayama ,  Haruhide Kimura

    IPC分类号： A61K31/5415 ,  C07D279/16

    CPC分类号： C07D263/58 ,  A61K31/5415 ,  C07D279/08

    摘要： As prophylactic and/or therapeutic agents for cardiovascular diseases, bone or joint diseases, infectious diseases, inflammatory diseases, kidney diseases, etc. having safe and excellent effects of cell death inhibition, MIF binding, etc., there are provided compounds represented by formula: [wherein, R1 represents a halogen atom, etc., R2 represents a group represented by formula: (wherein, R3 represents hydrogen atom, an optionally substituted alkoxy, etc., R4 represents hydrogen atom, bromine atom, cyano, etc., R5 represents hydrogen atom, hydroxy, etc., R6 represents hydrogen atom, etc., R7 represents hydrogen atom, etc.) etc., and n represents an integer of 0 to 4] or salts thereof.

    摘要翻译： 作为具有安全且优异的细胞死亡抑制作用，MIF结合等的心血管疾病，骨或关节疾病，感染性疾病，炎性疾病，肾脏疾病等的预防和/或治疗剂，提供了式 ：

    Multilayer wiring substrate and manufacturing method of multilayer wiring substrate
    9.
    发明授权
    Multilayer wiring substrate and manufacturing method of multilayer wiring substrate 失效
    多层布线基板及多层布线基板的制造方法

    公开(公告)号：US08604350B2

    公开(公告)日：2013-12-10

    申请号：US13143490

    申请日：2011-02-22

    申请人： Tsuyoshi Himori ,  Shogo Hirai ,  Hiroyuki Ishitomi ,  Satoru Tomekawa ,  Yutaka Nakayama

    发明人： Tsuyoshi Himori ,  Shogo Hirai ,  Hiroyuki Ishitomi ,  Satoru Tomekawa ,  Yutaka Nakayama

    IPC分类号： H05K1/09 ,  H05K1/11 ,  H01K3/10

    CPC分类号： H05K3/4069 ,  H05K3/4623 ,  H05K3/4626 ,  H05K2201/0195 ,  H05K2201/0272 ,  H05K2203/0425

    摘要： A multilayer wiring board includes an insulating resin layer, wirings laid on their respective opposite surfaces of the insulating resin layer, and a via-hole conductor for electrically connecting the wirings. The via-hole conductor includes metal and resin portions. The metal portion includes first metal regions including a joined unit made of copper particles for connecting the wirings, second metal regions mainly composed of, for example, tin, a tin-copper alloy, or a tin-copper intermetallic compound, and third metal regions mainly composed of bismuth and in contact with the second metal regions. The copper particles forming the joined unit are in plane contact with one another to form plane contact portions, and the second metal regions at least partially are in contact with the first metal regions.

    摘要翻译： 多层布线板包括绝缘树脂层，布置在其绝缘树脂层的相应相对表面上的布线，以及用于电连接布线的通孔导体。 通孔导体包括金属和树脂部分。 金属部分包括第一金属区域，其包括由用于连接布线的铜颗粒形成的接合单元，主要由例如锡，锡 - 铜合金或锡 - 铜金属间化合物构成的第二金属区域和第三金属区域 主要由铋组成并与第二金属区域接触。 形成接合单元的铜粒子彼此平面接触以形成平面接触部分，并且第二金属区域至少部分地与第一金属区域接触。