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公开(公告)号：US11137401B2
公开(公告)日：2021-10-05
申请号：US13057515
申请日：2009-08-05
申请人： Fumiyoshi Okano , Kana Suzuki
发明人： Fumiyoshi Okano , Kana Suzuki
IPC分类号： G01N33/574 , C12Q1/6886
摘要： The present invention relates to a method for detecting cancer, comprising measuring the expression of a polypeptide having a reactivity of binding to an antibody against a CAPRIN-1 protein having an amino acid sequence shown in any one of the even-numbered SEQ ID NOS: 2-30 in the Sequence Listing via an antigen-antibody reaction in a sample separated from a living organism, and, a reagent for detecting a cancer comprising the CAPRIN-1 protein or a fragment thereof, an antibody against the CAPRIN-1 protein or a fragment thereof, or a polynucleotide encoding the CAPRIN-1 protein or a fragment thereof.
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公开(公告)号：US09249409B2
公开(公告)日：2016-02-02
申请号：US12739689
申请日：2008-10-23
申请人： Fumiyoshi Okano , Kana Suzuki
发明人： Fumiyoshi Okano , Kana Suzuki
IPC分类号： G01N33/53 , G01N33/574 , C12N15/10
CPC分类号： C12N15/1037 , G01N33/57484 , G01N2333/4727 , G01N2333/723
摘要： A method for detecting a cancer(s) based on an expression of prescribed polypeptides is disclosed. These polypeptides were isolated, by the SEREX method using a cDNA library derived from canine testis and serum from a cancer-bearing dog, as a polypeptide which binds to an antibody existing in serum derived from cancer-bearing living body. Because these polypeptides react with antibodies specifically existing in serum of a cancer patient, cancers in a living body can be detected by measuring the antibody in a sample. Cancers in a living body can also be detected by measuring the antigen protein of the antibody per se or mRNA encoding it.
摘要翻译： 公开了一种基于规定多肽的表达检测癌症的方法。 通过使用来自犬睾丸的cDNA文库和来自携带癌症的狗的血清的SEREX方法，分离这些多肽作为与存在于含有癌的活体的血清中存在的抗体结合的多肽。 因为这些多肽与癌症患者血清中特异性存在的抗体反应，所以可以通过测量样品中的抗体来检测活体中的癌症。 也可以通过测量抗体本身的抗原蛋白或编码它的mRNA来检测活体中的癌症。
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公开(公告)号：US20110136121A1
公开(公告)日：2011-06-09
申请号：US13057515
申请日：2009-08-05
申请人： Fumiyoshi Okano , Kana Suzuki
发明人： Fumiyoshi Okano , Kana Suzuki
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/112 , G01N33/57407
摘要： The present invention relates to a method for detecting cancer, comprising measuring the expression of a polypeptide having a reactivity of binding to an antibody against a CAPRIN-1 protein having an amino acid sequence shown in any one of the even-numbered SEQ ID NOS: 2-30 in the Sequence Listing via an antigen-antibody reaction in a sample separated from a living organism, and, a reagent for detecting a cancer comprising the CAPRIN-1 protein or a fragment thereof, an antibody against the CAPRIN-1 protein or a fragment thereof, or a polynucleotide encoding the CAPRIN-1 protein or a fragment thereof.
摘要翻译： 本发明涉及一种检测癌症的方法，包括测定具有与抗体相对于抗体的抗体的反应性的多肽的表达，所述CAPRIN-1蛋白质具有偶数序列SEQ ID NO： 2-30在序列表中通过从活体分离的样品中的抗原 - 抗体反应，和用于检测包含CAPRIN-1蛋白或其片段的癌症的试剂，针对CAPRIN-1蛋白的抗体或 或其编码CAPRIN-1蛋白或其片段的多核苷酸。
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公开(公告)号：US20100297646A1
公开(公告)日：2010-11-25
申请号：US12739689
申请日：2008-10-23
申请人： Fumiyoshi Okano , Kana Suzuki
发明人： Fumiyoshi Okano , Kana Suzuki
CPC分类号： C12N15/1037 , G01N33/57484 , G01N2333/4727 , G01N2333/723
摘要： A method for detecting a cancer(s) based on an expression of prescribed polypeptides is disclosed. These polypeptides were isolated, by the SEREX method using a cDNA library derived from canine testis and serum from a cancer-bearing dog, as a polypeptide which binds to an antibody existing in serum derived from cancer-bearing living body. Because these polypeptides react with antibodies specifically existing in serum of a cancer patient, cancers in a living body can be detected by measuring the antibody in a sample. Cancers in a living body can also be detected by measuring the antigen protein of the antibody per se or mRNA encoding it.
摘要翻译： 公开了一种基于规定多肽的表达检测癌症的方法。 通过使用来自犬睾丸的cDNA文库和来自携带癌症的狗的血清的SEREX方法，分离这些多肽作为与存在于含有癌的活体的血清中存在的抗体结合的多肽。 因为这些多肽与癌症患者血清中特异性存在的抗体反应，所以可以通过测量样品中的抗体来检测活体中的癌症。 也可以通过测量抗体本身的抗原蛋白或编码它的mRNA来检测活体中的癌症。
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