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1.发明授权Substituted pyrazin-2-ones and substituted 5,6,7,8-tetrahydroquinoxalin-2-ones and methods of use thereof 有权取代的吡嗪-2-酮和取代的5,6,7,8-四氢喹喔啉-2-酮及其使用方法公开(公告)号：US08815859B2
公开(公告)日：2014-08-26
申请号：US12990098
申请日：2009-03-31
IPC分类号： A61K31/4965 , A61K31/498 , C07D241/18 , C07D241/44
CPC分类号： C07D241/08 , C07D241/18 , C07D241/38 , C07D401/04 , C07D403/04 , C07D405/04
摘要： Arylpyrazinone derivatives of formula (I), as insulin secretion stimulators, the preparation and use of these pyrazinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.
摘要翻译： 式（I）的吡咯烷酮衍生物作为胰岛素分泌刺激剂，这些吡嗪酮衍生物用于预防和/或治疗糖尿病和病理相关的制备和用途。
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2.发明授权Pyridopyrazinones derivatives insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes 有权吡吡嗪酮衍生物胰岛素分泌刺激剂，获得它们的方法及其用于治疗糖尿病的用途公开(公告)号：US08642617B2
公开(公告)日：2014-02-04
申请号：US13358264
申请日：2012-01-25
IPC分类号： A61K31/44
CPC分类号： C07D471/04
摘要： The present invention relates to pyridopyrazinone derivatives of formula (I), wherein X, Y, Z1 W, A and R1 are as defined in claim 1, as insulin secretion stimulators. The invention also relates to the preparation and use of these pyridopyrazinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.
摘要翻译： 本发明涉及式（I）的吡啶并吡唑酮衍生物，其中X，Y，Z 1 W，A和R 1如权利要求1中所定义，作为胰岛素分泌刺激剂。 本发明还涉及这些吡哆吡嗪酮衍生物用于预防和/或治疗相关的糖尿病和病症的制备和用途。
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3.发明授权Quinoxalinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes 有权喹喔啉酮衍生物作为胰岛素分泌刺激剂，获得它们的方法及其用于治疗糖尿病的用途公开(公告)号：US08415352B2
公开(公告)日：2013-04-09
申请号：US12920736
申请日：2009-01-15
IPC分类号： A61K31/495
CPC分类号： C07D413/10 , C07D241/44 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10
摘要： The present invention relates to quinoxalinone derivatives of formula (I): wherein R1, R2, R3, R4, R5 and R6 are as defined herein, as insulin secretion stimulators. Specific such quinoxaline compounds are also an aspect of the invention. The invention also relates to the preparation and use of these quinoxalinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.
摘要翻译： 本发明涉及式（I）的喹喔啉酮衍生物：其中R1，R2，R3，R4，R5和R6如本文所定义，作为胰岛素分泌刺激剂。 具体的这种喹喔啉化合物也是本发明的一个方面。 本发明还涉及这些喹喔啉酮衍生物用于预防和/或治疗相关的糖尿病和病理学的制备和用途。
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4.发明申请Arylpyrazinone derivatives insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes 有权芳基吡嗪酮衍生物胰岛素分泌刺激剂，获得它们的方法及其用于治疗糖尿病的用途公开(公告)号：US20110046159A1
公开(公告)日：2011-02-24
申请号：US12990098
申请日：2009-03-31
IPC分类号： A61K31/497 , C07D241/18 , C07D401/10 , A61K31/4965 , A61P3/10
CPC分类号： C07D241/08 , C07D241/18 , C07D241/38 , C07D401/04 , C07D403/04 , C07D405/04
摘要： The present invention relates to arylpyrazinone derivatives of formula (I), wherein R1, R2, R3 and A are as defined in claim 1, as insulin secretion stimulators. The invention also relates to the preparation and use of these pyrazinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.
摘要翻译： 本发明涉及式（I）的芳基吡嗪酮衍生物，其中R1，R2，R3和A如权利要求1中所定义，作为胰岛素分泌刺激剂。 本发明还涉及这些吡嗪酮衍生物用于预防和/或治疗相关的糖尿病和病理学的制备和用途。
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5.发明申请Quinoxalinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes 有权喹喔啉酮衍生物作为胰岛素分泌刺激剂，获得它们的方法及其用于治疗糖尿病的用途公开(公告)号：US20110015194A1
公开(公告)日：2011-01-20
申请号：US12920736
申请日：2009-01-15
IPC分类号： A61K31/5377 , C07D241/44 , A61K31/498 , A61P3/10 , C07D413/10
CPC分类号： C07D413/10 , C07D241/44 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10
摘要： The present invention relates to quinoxalinone derivatives of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as defined in claim 1, as insulin secretion stimulators. The invention also relates to the preparation and use of these quinoxalinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.Other preferred compounds are compounds of general formula (I), wherein R1, R2, R3, R4, R5 and R6 can be optionally substituted by one or more groups selected from Z;
摘要翻译： 本发明涉及式（I）的喹喔啉酮衍生物，其中R1，R2，R3，R4，R5和R6如权利要求1中所定义，作为胰岛素分泌刺激剂。 本发明还涉及这些喹喔啉酮衍生物用于预防和/或治疗相关的糖尿病和病理学的制备和用途。 其它优选的化合物是通式（I）的化合物，其中R 1，R 2，R 3，R 4，R 5和R 6可任选被一个或多个选自Z的基团取代;
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6.发明授权Pyrazinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes 有权作为胰岛素分泌刺激剂的吡嗪酮衍生物，其获得方法及其用于治疗糖尿病的用途公开(公告)号：US08637522B2
公开(公告)日：2014-01-28
申请号：US12920932
申请日：2009-01-15
IPC分类号： C07D241/08
CPC分类号： C07D241/08 , C07D241/18
摘要： The present invention relates to pyrazinone derivatives of formula (I), wherein n, R1, R2, R3 and R4 are as defined in claim 1, as insulin secretion stimulators. The invention also relates to the preparation and use of these pyrazinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.
摘要翻译： 本发明涉及式（I）的吡嗪酮衍生物，其中n，R1，R2，R3和R4如权利要求1中所定义，作为胰岛素分泌刺激剂。 本发明还涉及这些吡嗪酮衍生物用于预防和/或治疗相关的糖尿病和病理学的制备和用途。
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7.发明申请Pyrazinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes 有权作为胰岛素分泌刺激剂的吡嗪酮衍生物，其获得方法及其用于治疗糖尿病的用途公开(公告)号：US20110015210A1
公开(公告)日：2011-01-20
申请号：US12920932
申请日：2009-01-15
IPC分类号： A61K31/497 , C07D241/18 , A61K31/4965 , A61P3/10 , A61P5/50 , A61P3/06 , A61P3/04 , A61P9/10 , A61P9/12
CPC分类号： C07D241/08 , C07D241/18
摘要： The present invention relates to pyrazinone derivatives of formula (I), wherein n, R1, R2, R3 and R4 are as defined in claim 1, as insulin secretion stimulators. The invention also relates to the preparation and use of these pyrazinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.
摘要翻译： 本发明涉及式（I）的吡嗪酮衍生物，其中n，R1，R2，R3和R4如权利要求1中所定义，作为胰岛素分泌刺激剂。 本发明还涉及这些吡嗪酮衍生物用于预防和/或治疗相关的糖尿病和病理学的制备和用途。
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8.发明申请PYRIDOPYRAZINONES DERIVATIVES INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES 有权吡咯烷酮衍生物胰岛素分泌刺激物，用于获得它们的方法及其用于治疗糖尿病的方法公开(公告)号：US20120122876A1
公开(公告)日：2012-05-17
申请号：US13358264
申请日：2012-01-25
IPC分类号： A61K31/519 , A61P29/00 , A61P3/04 , C07D471/04 , A61P3/10
CPC分类号： C07D471/04
摘要： The present invention relates to pyridopyrazinone derivatives of formula (I), wherein X, Y, Z1 W, A and R1 are as defined in claim 1, as insulin secretion stimulators. The invention also relates to the preparation and use of these pyridopyrazinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.
摘要翻译： 本发明涉及式（I）的吡啶并吡唑酮衍生物，其中X，Y，Z 1 W，A和R 1如权利要求1中所定义，作为胰岛素分泌刺激剂。 本发明还涉及这些吡哆吡嗪酮衍生物用于预防和/或治疗相关的糖尿病和病症的制备和用途。
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9.发明授权4-(1-piperazinyl) benzoic acid derivatives, process for preparing them and their therapeutic applications 失效4-（1-哌嗪基）苯甲酸衍生物，其制备方法及其治疗应用公开(公告)号：US06281215B1
公开(公告)日：2001-08-28
申请号：US09331155
申请日：1999-10-20
IPC分类号： A61K31495
CPC分类号： C07D295/15 , C07D215/08 , C07D307/52
摘要： New 4-(1-piperazinyl)benzoic acid derivatives of the formula (I) are described. Also described is methods for making these compounds and their use as therapeutic agents. In particular, the compounds find use in the treatment of diabetes.
摘要翻译： 描述了式（I）的新的4-（1-哌嗪基）苯甲酸衍生物。 还描述了制备这些化合物及其作为治疗剂的用途的方法。 特别地，这些化合物可用于治疗糖尿病。
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公开(公告)号：US06437143B1
公开(公告)日：2002-08-20
申请号：US09202076
申请日：1998-12-07
申请人： Gérard Moinet , Gérard Botton , Etienne Prugnard , Liliane Doare , Micheline Kergoat , Didier Mesangeau
发明人： Gérard Moinet , Gérard Botton , Etienne Prugnard , Liliane Doare , Micheline Kergoat , Didier Mesangeau
IPC分类号： C07D27734
摘要： The present invention relates to the field of chemistry and more particularly to that of therapeutic chemistry. The subject of the present invention is more precisely new 5-phenoxyalkyl-2,4-thiazolidinediones of general formula I: in which A represents a linear or branched alkylene group comprising from 2 to 16 carbon atoms D represents a homo- or heterocarbon mono-, di- or tricyclic aromatic structure which may include one or more heteroatoms X represents the substituent of the aromatic structure and is as defined in Claim 1 n is an integer ranging from 1 to 3 with the proviso that if A represents a butyl radical, does not represent the 4-chlorophenyl group. The invention also relates to the tautomeric forms, to the enantiomers, diastereoisomers and epimers of the compounds of general formula I, in free or salified form. The present invention also relates to the processes for producing the compounds of general formula I, their use as antidiabetic agents, and in the treatment of the metabolic syndrome of insulin resistance, as well as the pharmaceutical compositions which contain the compounds of general formula I.
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