公开(公告)号：US09637768B2

公开(公告)日：2017-05-02

申请号：US14894757

申请日：2014-05-30

申请人： GENECHEM INC.

发明人： Jin Suk Woo ,  Byung-Gee Kim ,  Dae Hee Kim ,  Yun Hee Choi ,  Jae-Kyung Song ,  Sun Youp Kang ,  Won Min Seo ,  Ji Young Yang ,  Sang Mi Lee

IPC分类号： C12P19/18 ,  C12P19/26 ,  C12P19/60 ,  C07K9/00 ,  C12P19/12 ,  C12P21/00 ,  C12P19/44

CPC分类号： C12P19/18 ,  C07K9/008 ,  C12P19/12 ,  C12P19/26 ,  C12P19/44 ,  C12P19/60 ,  C12P21/005 ,  Y02P20/582

摘要： The present invention relates to a method for preparing a sialic acid derivative characterized by performing both of a process for preparing CMP-N-acetylneuraminic acid using N-acetyl-D-glucosamine and a process for preparing the sialic acid (neuraminic acid) derivative that combines a sialic acid with a galactose derivative or a lactose derivative, together, in one reactor. According to the method for preparing a sialic acid derivative of the present invention, expensive cytidine 5′-monophosphate (CMP) is capable of being recycled in a reactor, such that an amount of the CMP introduced into the reactor may be reduced, and the sialic acid derivative is capable of being prepared at a significantly high efficiency by using cheap N-acetyl-D-glucosamine, and pyruvate as substrates.

公开(公告)号：US20160130621A1

公开(公告)日：2016-05-12

申请号：US14894757

申请日：2014-05-30

申请人： GENECHEM INC.

发明人： Jin Suk Woo ,  Byung-Gee Kim ,  Dae Hee Kim ,  Yun Hee Choi ,  Jae-Kyung Song ,  Sun Youp Kang ,  Won Min Seo ,  Ji Young Yang ,  Sang Mi Lee

IPC分类号： C12P19/18 ,  C12P19/26 ,  C12P19/12 ,  C07K9/00 ,  C12P21/00

CPC分类号： C12P19/18 ,  C07K9/008 ,  C12P19/12 ,  C12P19/26 ,  C12P19/44 ,  C12P19/60 ,  C12P21/005 ,  Y02P20/582

摘要： The present invention relates to a method for preparing a sialic acid derivative characterized by performing both of a process for preparing CMP-N-acetylneuraminic acid using N-acetyl-D-glucosamine and a process for preparing the sialic acid (neuraminic acid) derivative that combines a sialic acid with a galactose derivative or a lactose derivative, together, in one reactor. According to the method for preparing a sialic acid derivative of the present invention, expensive cytidine 5′-monophosphate (CMP) is capable of being recycled in a reactor, such that an amount of the CMP introduced into the reactor may be reduced, and the sialic acid derivative is capable of being prepared at a significantly high efficiency by using cheap N-acetyl-D-glucosamine, and pyruvate as substrates.

摘要翻译： 本发明涉及一种唾液酸衍生物的制备方法，其特征在于使用N-乙酰基-D-葡糖胺制备CMP-N-乙酰神经氨酸的方法和制备唾液酸（神经氨酸）衍生物的方法， 在一个反应​​器中将唾液酸与半乳糖衍生物或乳糖衍生物结合在一起。 根据本发明的唾液酸衍生物的制备方法，可以将昂贵的胞苷5'-单磷酸（CMP）在反应器中循环使用，使得引入到反应器中的CMP量减少， 唾液酸衍生物能够通过使用便宜的N-乙酰基-D-葡糖胺和丙酮酸盐作为底物以显着高的效率制备。