公开(公告)号：US09637768B2

公开(公告)日：2017-05-02

申请号：US14894757

申请日：2014-05-30

申请人： GENECHEM INC.

发明人： Jin Suk Woo ,  Byung-Gee Kim ,  Dae Hee Kim ,  Yun Hee Choi ,  Jae-Kyung Song ,  Sun Youp Kang ,  Won Min Seo ,  Ji Young Yang ,  Sang Mi Lee

IPC分类号： C12P19/18 ,  C12P19/26 ,  C12P19/60 ,  C07K9/00 ,  C12P19/12 ,  C12P21/00 ,  C12P19/44

CPC分类号： C12P19/18 ,  C07K9/008 ,  C12P19/12 ,  C12P19/26 ,  C12P19/44 ,  C12P19/60 ,  C12P21/005 ,  Y02P20/582

摘要： The present invention relates to a method for preparing a sialic acid derivative characterized by performing both of a process for preparing CMP-N-acetylneuraminic acid using N-acetyl-D-glucosamine and a process for preparing the sialic acid (neuraminic acid) derivative that combines a sialic acid with a galactose derivative or a lactose derivative, together, in one reactor. According to the method for preparing a sialic acid derivative of the present invention, expensive cytidine 5′-monophosphate (CMP) is capable of being recycled in a reactor, such that an amount of the CMP introduced into the reactor may be reduced, and the sialic acid derivative is capable of being prepared at a significantly high efficiency by using cheap N-acetyl-D-glucosamine, and pyruvate as substrates.

公开(公告)号：US20230270788A1

公开(公告)日：2023-08-31

申请号：US17767453

申请日：2020-10-08

申请人： GENECHEM INC. ,  UNIVERSITY INDUSTRY FOUNDATION, YONSEI UNIVERSITY WONJU CAMPUS ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION,YONSEI UNIVERSITY

发明人： Sung Hoon KIM ,  Ah Reum BAEK ,  Sung Rae CHO ,  Jin Suk WOO ,  Li La KIM ,  Dae Hee KIM

IPC分类号： A61K35/28 ,  A61K35/545 ,  C12N5/0775

CPC分类号： A61K35/28 ,  A61K35/545 ,  C12N5/0662 ,  C12N2500/34 ,  C12N2500/38 ,  C12N2501/11 ,  C12N2501/155 ,  C12N2501/12 ,  C12N2501/237

摘要： The present application pertains to a sialyloligosaccharide for augmenting the stemness of stem cells and a use thereof and provides a composition for augmenting stemness of stem cells, a method of culturing stem cells in a medium containing a sialyloligosaccharide, a method of augmenting stemness of stem cells, a stem cell with augmented stemness, obtained by the method, and a cell therapy composition including the stem cells as an active ingredient. The composition or the method according to one or more embodiments may suppress the aging of stem cells and may maintain and augment stemness.

公开(公告)号：US20220089631A1

公开(公告)日：2022-03-24

申请号：US17270184

申请日：2019-08-22

申请人： Genechem Inc.

发明人： Jin Suk WOO ,  Dae Hee KIM ,  Sang Mi LEE ,  Sang Eun YOO ,  Won Min SEO ,  Ji Young YANG ,  Li La KIM

IPC分类号： C07H17/04 ,  C07H15/18 ,  A61K9/00 ,  A61K9/48 ,  A61K9/20 ,  A61P31/16

摘要： The present invention relates to a use of a compound comprising a multivalent sialyloligosaccharide residue, an optical isomer thereof or a pharmaceutically acceptable salt thereof, and a composition comprising the same as an active ingredient for preventing or treating viral infectious diseases. The present invention shows high hemagglutination inhibitory activity and virus neutralizing activity so as to have excellent antiviral activity, thereby being effectively usable as a composition for preventing or treating viral infectious diseases.

公开(公告)号：US20160130621A1

公开(公告)日：2016-05-12

申请号：US14894757

申请日：2014-05-30

申请人： GENECHEM INC.

发明人： Jin Suk Woo ,  Byung-Gee Kim ,  Dae Hee Kim ,  Yun Hee Choi ,  Jae-Kyung Song ,  Sun Youp Kang ,  Won Min Seo ,  Ji Young Yang ,  Sang Mi Lee

IPC分类号： C12P19/18 ,  C12P19/26 ,  C12P19/12 ,  C07K9/00 ,  C12P21/00

CPC分类号： C12P19/18 ,  C07K9/008 ,  C12P19/12 ,  C12P19/26 ,  C12P19/44 ,  C12P19/60 ,  C12P21/005 ,  Y02P20/582

摘要： The present invention relates to a method for preparing a sialic acid derivative characterized by performing both of a process for preparing CMP-N-acetylneuraminic acid using N-acetyl-D-glucosamine and a process for preparing the sialic acid (neuraminic acid) derivative that combines a sialic acid with a galactose derivative or a lactose derivative, together, in one reactor. According to the method for preparing a sialic acid derivative of the present invention, expensive cytidine 5′-monophosphate (CMP) is capable of being recycled in a reactor, such that an amount of the CMP introduced into the reactor may be reduced, and the sialic acid derivative is capable of being prepared at a significantly high efficiency by using cheap N-acetyl-D-glucosamine, and pyruvate as substrates.

摘要翻译： 本发明涉及一种唾液酸衍生物的制备方法，其特征在于使用N-乙酰基-D-葡糖胺制备CMP-N-乙酰神经氨酸的方法和制备唾液酸（神经氨酸）衍生物的方法， 在一个反应​​器中将唾液酸与半乳糖衍生物或乳糖衍生物结合在一起。 根据本发明的唾液酸衍生物的制备方法，可以将昂贵的胞苷5'-单磷酸（CMP）在反应器中循环使用，使得引入到反应器中的CMP量减少， 唾液酸衍生物能够通过使用便宜的N-乙酰基-D-葡糖胺和丙酮酸盐作为底物以显着高的效率制备。