公开(公告)号：US20250164502A1

公开(公告)日：2025-05-22

申请号：US18515382

申请日：2023-11-21

Applicant: Genentech, Inc. ,  University of Copenhagen

Inventor： Cameron L. Noland ,  Jian Mehr-Dean Payandeh ,  Stephan Alexander Pless ,  Han Chow Chua ,  Marc Kschonsak

IPC: G01N33/68 ,  C07K14/47

Abstract: The present disclosure relates to mutant human NaX ion channel (“NaX”) proteins and screening methods using a mutant human NaX that may be used to identify molecules that modulate the activity of human NaX. For example, in some embodiments, screening methods involve performing an ion channel assay on a mutant human NaX in the presence of a potential NaX modulator. The disclosure also relates to molecules that act as modulators of human NaX and associated kits for detecting such molecules.

公开(公告)号：US20180312579A1

公开(公告)日：2018-11-01

申请号：US15837647

申请日：2017-12-11

Applicant: Genentech, Inc,

Inventor： Elaine Storm ,  Frederic J. de Sauvage ,  Jeremy M. Murray ,  Cameron L. Noland ,  Yan Wu ,  Christine Tan ,  Jo-Anne Hongo ,  Yongmei Chen

IPC: C07K16/18 ,  A61K39/395 ,  A61K45/06 ,  A61K47/68 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6843 ,  A61K2039/505 ,  C07K16/2818 ,  C07K16/3046 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided herein are anti-RSPO antibodies, in particular anti-RSPO2 antibodies and/or anti-RSPO3 antibodies, and methods of using the same.

公开(公告)号：US20150147333A1

公开(公告)日：2015-05-28

申请号：US14517709

申请日：2014-10-17

Applicant: GENENTECH, INC.

Inventor： Elaine Storm ,  Frederic J. de Sauvage ,  Jeremy M. Murray ,  Cameron L. Noland ,  Yan Wu ,  Christine Tan ,  Jo-Anne Hongo ,  Yongmei Chen

IPC: C07K16/18 ,  A61K39/395 ,  A61K45/06 ,  A61K47/48

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6843 ,  A61K2039/505 ,  C07K16/2818 ,  C07K16/3046 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided herein are anti-RSPO antibodies, in particular anti-RSPO2 antibodies and/or anti-RSPO3 antibodies, and methods of using the same.

Abstract translation: 本文提供抗RSPO抗体，特别是抗RSPO2抗体和/或抗RSPO3抗体，以及使用该抗RSP2抗体的方法。