公开(公告)号：US11247989B2

公开(公告)日：2022-02-15

申请号：US16198581

申请日：2018-11-21

Applicant: GENENTECH, INC. ,  CONSTELLATION PHARMACEUTICALS, INC.

Inventor： Patrick Cyr ,  Sarah Bronner ,  F. Anthony Romero ,  Steven Magnuson ,  Vickie Hsiao-Wei Tsui ,  Jeremy M. Murray ,  John Wai ,  Kwong Wah Lai ,  Fei Wang ,  Kevin X. Chen

IPC: C07D471/04 ,  C07D519/00

Abstract: The present invention relates to a compound formula (I): and to salts thereof, wherein R1, R2 X, and Y have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

公开(公告)号：US20150147333A1

公开(公告)日：2015-05-28

申请号：US14517709

申请日：2014-10-17

Applicant: GENENTECH, INC.

Inventor： Elaine Storm ,  Frederic J. de Sauvage ,  Jeremy M. Murray ,  Cameron L. Noland ,  Yan Wu ,  Christine Tan ,  Jo-Anne Hongo ,  Yongmei Chen

IPC: C07K16/18 ,  A61K39/395 ,  A61K45/06 ,  A61K47/48

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6843 ,  A61K2039/505 ,  C07K16/2818 ,  C07K16/3046 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided herein are anti-RSPO antibodies, in particular anti-RSPO2 antibodies and/or anti-RSPO3 antibodies, and methods of using the same.

Abstract translation: 本文提供抗RSPO抗体，特别是抗RSPO2抗体和/或抗RSPO3抗体，以及使用该抗RSP2抗体的方法。

公开(公告)号：US20180312579A1

公开(公告)日：2018-11-01

申请号：US15837647

申请日：2017-12-11

Applicant: Genentech, Inc,

Inventor： Elaine Storm ,  Frederic J. de Sauvage ,  Jeremy M. Murray ,  Cameron L. Noland ,  Yan Wu ,  Christine Tan ,  Jo-Anne Hongo ,  Yongmei Chen

IPC: C07K16/18 ,  A61K39/395 ,  A61K45/06 ,  A61K47/68 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6843 ,  A61K2039/505 ,  C07K16/2818 ,  C07K16/3046 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided herein are anti-RSPO antibodies, in particular anti-RSPO2 antibodies and/or anti-RSPO3 antibodies, and methods of using the same.

公开(公告)号：US09573899B2

公开(公告)日：2017-02-21

申请号：US15074027

申请日：2016-03-18

Applicant: Genentech, Inc.

Inventor： Robert Blake ,  Paola Di Lello ,  Jason Drummond ,  Christine Johanna Heideker ,  Lorna Kategaya ,  Till Maurer ,  Jeremy M. Murray ,  Chudi Ndubaku ,  Richard Pastor ,  Lionel Rouge ,  Vickie Tsui ,  Ingrid E. Wertz ,  Kebing Yu

IPC: C07D213/02 ,  C07D213/73 ,  A61K31/44 ,  A61K45/06 ,  C07D409/04 ,  A61K31/4436 ,  A61K31/5355 ,  C07D401/04 ,  A61K31/444 ,  A61K31/506 ,  A61K31/496 ,  A61K31/4439 ,  C07D213/74 ,  C07D403/04

CPC classification number: C07D213/73 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5355 ,  A61K45/06 ,  C07D213/74 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04

Abstract: 2-Aminopyridine compounds of Formula I are provided, and various substituents including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for modulating USP7, and for treating cancer and immune disorders such as inflammation mediated by USP7. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract translation: 提供了式I的2-氨基吡啶化合物，以及可用于调节USP7的各种取代基，包括立体异构体，互变异构体和其药学上可接受的盐，以及用于治疗癌症和免疫病症如USP7介导的炎症。 公开了使用式I化合物进行体外，原位和体内诊断以及哺乳动物细胞或相关病理学条件下的这些疾病的治疗的方法。

公开(公告)号：US20220127265A1

公开(公告)日：2022-04-28

申请号：US17570139

申请日：2022-01-06

Applicant: GENENTECH, INC. ,  CONSTELLATION PHARMACEUTICALS, INC.

Inventor： Patrick Cyr ,  Sarah Bronner ,  F. Anthony Romero ,  Steven Magnuson ,  Vickie Hsiao-Wei Tsui ,  Jeremy M. Murray ,  John Wai ,  Kwong Wah Lai ,  Fei Wang ,  Kevin X. Chen

IPC: C07D471/04 ,  C07D519/00

Abstract: The present invention relates to a compound formula (I): and to salts thereof, wherein R1, R2 X, and Y have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

公开(公告)号：US20190241558A1

公开(公告)日：2019-08-08

申请号：US16198581

申请日：2018-11-21

Applicant: GENENTECH, INC. ,  CONSTELLATION PHARMACEUTICALS, INC.

Inventor： Patrick Cyr ,  Sarah Bronner ,  F. Anthony Romero ,  Steven Magnuson ,  Vickie Hsiao-Wei Tsui ,  Jeremy M. Murray ,  John Wai ,  Kwong Wah Lai ,  Fei Wang ,  Kevin X. Chen

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: The present invention relates to a compound formula (I): and to salts thereof, wherein R1, R2 X, and Y have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

公开(公告)号：US20160272588A1

公开(公告)日：2016-09-22

申请号：US15074027

申请日：2016-03-18

Applicant: Genentech, Inc.

Inventor： Robert Blake ,  Paola Di Lello ,  Jake Drummond ,  Christine Johanna Heideker ,  Lorna Kategaya ,  Till Maurer ,  Jeremy M. Murray ,  Chudi Ndubaku ,  Richard Pastor ,  Lionel Rouge ,  Vickie Tsui ,  Ingrid E. Wertz ,  Kebing Yu

IPC: C07D213/73 ,  A61K45/06 ,  C07D409/04 ,  A61K31/4436 ,  C07D213/74 ,  C07D401/04 ,  A61K31/444 ,  A61K31/506 ,  A61K31/496 ,  A61K31/4439 ,  A61K31/44 ,  A61K31/5355

CPC classification number: C07D213/73 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5355 ,  A61K45/06 ,  C07D213/74 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04

Abstract: 2-Aminopyridine compounds of Formula I are provided, and various substituents including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for modulating USP7, and for treating cancer and immune disorders such as inflammation mediated by USP7. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.