公开(公告)号：US20210403943A1

公开(公告)日：2021-12-30

申请号：US17355605

申请日：2021-06-23

Applicant: GENENTECH, INC.

Inventor： Amy SHEN ,  Shahram MISAGHI ,  Cynthia Young LAM

IPC: C12N15/85 ,  C12P21/00 ,  C12N5/10 ,  C07K16/00

Abstract: The presently disclosed subject matter relates to targeted integration (TI) host cells suitable for the expression of recombinant proteins wherein those TI host cells have been subjected to supertransfection resulting in the random integration (RI) of exogenous nucleic acids encodes into their genome, as well as methods of producing and using said supertransfected TI host cells.