-
公开(公告)号：US20220002430A1
公开(公告)日：2022-01-06
申请号：US17235805
申请日：2021-04-20
Applicant: Genentech, Inc.
Inventor： Camellia W. ADAMS , Andrew C. CHAN , Craig W. CROWLEY , Henry B. LOWMAN , Gerald R. NAKAMURA , Leonard G. PRESTA
IPC: C07K16/28
Abstract: The invention provides humanized and chimeric anti-CD20 antibodies for treatment of CD20 positive malignancies and autoimmune diseases.
-
公开(公告)号：US20160060330A1
公开(公告)日：2016-03-03
申请号：US14835494
申请日：2015-08-25
Applicant: Genentech, Inc.
Inventor： Leonard G. PRESTA
IPC: C07K16/18
CPC classification number: C07K16/18 , A61K2039/505 , C07K16/28 , C07K16/2839 , C07K16/2887 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/52 , C07K2317/524 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2319/00 , C07K2319/30 , C12N2799/022
Abstract: The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.
Abstract translation: 本发明涉及包含变体Fc区的多肽。 更具体地，本发明涉及由于Fc区中一个或多个氨基酸修饰而具有改变的效应子功能的含Fc区的多肽。
-
公开(公告)号：US20170158773A1
公开(公告)日：2017-06-08
申请号：US15217838
申请日：2016-07-22
Applicant: Genentech, Inc.
Inventor： Camellia W. ADAMS , Andrew C. CHAN , Craig W. CROWLEY , Henry B. LOWMAN , Gerald R. NAKAMURA , Leonard G. PRESTA
IPC: C07K16/28
CPC classification number: C07K16/2887 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/75 , C07K2317/92
Abstract: The invention provides humanized and chimeric anti-CD20 antibodies for treatment of CD20 positive malignancies and autoimmune diseases.
-
Patent Agency Ranking
公开(公告)号：US20140342404A1
公开(公告)日：2014-11-20
申请号：US13860462
申请日：2013-04-10
Applicant: GENENTECH, INC.
Inventor： Leonard G. PRESTA
IPC: C07K16/28
CPC classification number: C07K16/18 , A61K2039/505 , C07K16/28 , C07K16/2839 , C07K16/2887 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/52 , C07K2317/524 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2319/00 , C07K2319/30 , C12N2799/022
Abstract: The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.
-
公开(公告)号：US20140147436A1
公开(公告)日：2014-05-29
申请号：US13946920
申请日：2013-07-19
Applicant: GENENTECH, INC.
Inventor： Leonard G. PRESTA
IPC: C07K16/28
CPC classification number: C07K16/18 , A61K2039/505 , C07K16/28 , C07K16/2839 , C07K16/2887 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/52 , C07K2317/524 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2319/00 , C07K2319/30 , C12N2799/022
Abstract: The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.
Abstract translation: 本发明涉及包含变体Fc区的多肽。 更具体地，本发明涉及由于Fc区中一个或多个氨基酸修饰而具有改变的效应子功能的含Fc区的多肽。
-
6.发明申请METHOD FOR MAKING MULTISPECIFIC ANTIBODIES HAVING HETEROMULTIMERIC AND COMMON COMPONENTS 审中-公开制备具有异源性和共同成分的多重抗体的方法公开(公告)号：US20140322756A1
公开(公告)日：2014-10-30
申请号：US14142663
申请日：2013-12-27
Applicant: GENENTECH, INC.
Inventor： W. Robert ARATHOON , Paul J. CARTER , Anne M. MERCHANT , Leonard G. PRESTA
IPC: C07K16/28
CPC classification number: C07K16/2863 , A61K38/00 , C07K1/22 , C07K16/2809 , C07K16/2812 , C07K16/46 , C07K16/468 , C07K2317/732 , Y10S435/972
Abstract: The invention relates to a method of preparing heteromultimeric polypeptides such as bispecific antibodies, bispecific immunoadhesins and antibody-immunoadhesin chimeras. The invention also relates to the heteromultimers prepared using the method. Generally, the method provides a multispecific antibody having a common light chain associated with each heteromeric polypeptide having an antibody binding domain. Additionally the method further involves introducing into the multispecific antibody a specific and complementary interaction at the interface of a first polypeptide and the interface of a second polypeptide, so as to promote heteromultimer formation and hinder homomultimer formation; and/or a free thiol-containing residue at the interface of a first polypeptide and a corresponding free thiol-containing residue in the interface of a second polypeptide, such that a non-naturally occurring disulfide bond is formed between the first and second polypeptide. The method allows for the enhanced formation of the desired heteromultimer relative to undesired heteromultimers and homomultimers.
Abstract translation: 本发明涉及制备异源多聚体多肽如双特异性抗体，双特异性免疫粘附素和抗体免疫粘附素嵌合体的方法。 本发明还涉及使用该方法制备的异源多聚体。 通常，该方法提供具有与具有抗体结合结构域的每个异聚多肽相关联的共同轻链的多特异性抗体。 另外，该方法还包括将多特异性抗体引入第一多肽的界面处的第二多肽的界面上的特异性和互补相互作用，以促进异源多聚体形成并阻碍同源多聚体形成; 和/或在第二多肽的界面处的第一多肽和相应的游离含硫醇残基的界面处的游离含硫醇残基，使得在第一和第二多肽之间形成非天然存在的二硫键。 该方法允许相对于不想要的异多元反应物和同源多聚体增强所需异源多聚体的形成。
-
公开(公告)号：US20190071511A1
公开(公告)日：2019-03-07
申请号：US15905406
申请日：2018-02-26
Applicant: Genentech, Inc.
Inventor： Camellia W. ADAMS , Andrew C. CHAN , Craig W. CROWLEY , Henry B. LOWMAN , Gerald R. NAKAMURA , Leonard G. PRESTA
Abstract: The invention provides humanized and chimeric anti-CD20 antibodies for treatment of CD20 positive malignancies and autoimmune diseases.
-
公开(公告)号：US20140322221A1
公开(公告)日：2014-10-30
申请号：US14229683
申请日：2014-03-28
Applicant: Genentech, Inc.
Inventor： Kathy L. MILLER , Leonard G. PRESTA
IPC: C07K16/46 , A61K45/06 , A61K39/395 , A61K47/48
CPC classification number: C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/6879 , A61K2039/505 , C07K16/00 , C07K16/2878 , C07K16/2896 , C07K16/32 , C07K2317/55 , C07K2317/64 , C07K2317/73 , C07K2317/77 , C07K2319/00
Abstract: The present application describes engineered antibodies, with three or more functional antigen binding sites, and uses, such as therapeutic applications, for such engineered antibodies.
Abstract translation: 本申请描述了具有三个或更多个功能性抗原结合位点的工程抗体，以及用于这些工程化抗体的用途，例如治疗应用。
-
-
-
-
-
-
-
Search Results
8
records
(took 0.02 seconds)
