公开(公告)号：US20160319038A1

公开(公告)日：2016-11-03

申请号：US15214160

申请日：2016-07-19

Applicant: GENENTECH, INC.

Inventor： YONGMEI CHEN ,  James Ernst ,  Hok Seon Kim ,  Junichiro Sonoda ,  Christoph Spiess ,  Scott Stawicki ,  Yan Wu

IPC: C07K16/40 ,  C07K16/28

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/524 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/75 ,  C07K2317/92

Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.