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公开(公告)号：US20210025890A1
公开(公告)日：2021-01-28
申请号：US17063640
申请日：2020-10-05
申请人： GENENTECH, INC.
IPC分类号： G01N33/577 , G01N33/557 , G01N33/74
摘要： The presently disclosed subject matter provides antibodies that bind FGF21 and methods of using the same. In particular, the present disclosure provides immunoassay methods for detecting and quantifying active and total FGF21 levels in a sample and kits for performing such methods.
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公开(公告)号：US20180100018A1
公开(公告)日：2018-04-12
申请号：US15809232
申请日：2017-11-10
申请人： Genentech, Inc.
发明人： Junichiro Sonoda , Yan WU
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395 , C07K16/40 , A61K39/00
CPC分类号： C07K16/2863 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K16/40 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/56 , C07K2317/75 , C07K2317/92
摘要： The invention provides nucleic acid molecules encoding anti-fibroblast growth factor receptor-1 (FGFR1) antibodies and vectors and host cells comprising the nucleic acid molecules.
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公开(公告)号：US20210087283A1
公开(公告)日：2021-03-25
申请号：US17073498
申请日：2020-10-19
申请人： Genentech, Inc.
发明人： Junichiro Sonoda , Yan Wu
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06 , C07K16/40
摘要： The invention provides FGFR1 agonists, including agonistic anti-FGFR1 antibodies, and methods of using the same.
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公开(公告)号：US10246518B2
公开(公告)日：2019-04-02
申请号：US15837801
申请日：2017-12-11
申请人： Genentech, Inc.
发明人： Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
摘要： The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号：US09884919B2
公开(公告)日：2018-02-06
申请号：US15214160
申请日：2016-07-19
申请人： GENENTECH, INC.
发明人： Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
IPC分类号： A61K39/395 , C07K16/40 , C07K14/71 , C07K16/28 , A61K39/00
CPC分类号： C07K16/40 , A61K2039/505 , C07K14/71 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/75 , C07K2317/92
摘要： The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号：US09873748B2
公开(公告)日：2018-01-23
申请号：US14582100
申请日：2014-12-23
申请人： GENENTECH, INC.
发明人： Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
CPC分类号： C07K16/40 , A61K2039/505 , C07K14/71 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/75 , C07K2317/92
摘要： The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号：US20160319038A1
公开(公告)日：2016-11-03
申请号：US15214160
申请日：2016-07-19
申请人： GENENTECH, INC.
发明人： YONGMEI CHEN , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
CPC分类号： C07K16/40 , A61K2039/505 , C07K14/71 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/75 , C07K2317/92
摘要： The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号：US10882921B2
公开(公告)日：2021-01-05
申请号：US16284774
申请日：2019-02-25
申请人： GENENTECH, INC.
发明人： Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
摘要： The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号：US10208120B2
公开(公告)日：2019-02-19
申请号：US14934059
申请日：2015-11-05
申请人： Genentech, Inc.
发明人： Yiyuan Yin , Avi Ashkenazi , Paul J. Carter , Mark Chen , Junichiro Sonoda
摘要： The invention provides dual specific anti-FGFR2 and FGFR3 (FGFR2/3) antibodies, and compositions comprising and methods of using these antibodies.
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公开(公告)号：US20180105605A1
公开(公告)日：2018-04-19
申请号：US15837801
申请日：2017-12-11
申请人： Genentech, Inc.
发明人： Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
CPC分类号： C07K16/40 , A61K2039/505 , C07K14/71 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/75 , C07K2317/92
摘要： The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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