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公开(公告)号：US20160357905A1
公开(公告)日：2016-12-08
申请号：US14730032
申请日：2015-06-03
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brion Daryl Sarachan , John Frederick Graf , Michael John Gerdes
Abstract: Identification of regions-of-interest within cell maps is disclosed. In certain embodiments, identification of the regions-of interest is based on the use of biomarkers selected based on nucleic acid sequence data. The nucleic acid sequence data may be acquired for a homogeneous or heterogeneous set of cells present in the respective tissue sample.
Abstract translation: 公开了细胞图中感兴趣区域的识别。 在某些实施方案中，感兴趣区域的鉴定基于使用基于核酸序列数据选择的生物标志物。 核酸序列数据可以针对存在于各组织样品中的均质或异质的细胞组获得。
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公开(公告)号：US09607375B2
公开(公告)日：2017-03-28
申请号：US14729982
申请日：2015-06-03
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brion Daryl Sarachan , John Frederick Graf , Anup Sood , Vidya Pundalik Kamath
CPC classification number: G06F17/30259 , G06F19/00 , G06F19/321
Abstract: Dynamic linking of pathway maps and cell maps is disclosed in certain embodiments. In such embodiments, the pathway maps are linked to spatially-localized regional nucleic acid data (e.g., sequence data), as opposed to non-spatially selected nucleic acid data. The pathway map and cell map data may be linked so that interactions results in changes or updates to the linked map, such as the selection or highlighting of cells exhibiting pathway map characteristics specified by a user of updating of node values or states to correspond to that of a cell or cells selected by the user.
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公开(公告)号：US20170091527A1
公开(公告)日：2017-03-30
申请号：US14871667
申请日：2015-09-30
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brion Daryl Sarachan , John Frederick Graf , Vidya Pundalik Kamath
CPC classification number: G06K9/00147 , G06K9/00134 , G06K9/0014 , G06K9/3241 , G06K9/6215 , G06K9/6219 , G06K9/6224 , G06K9/6247
Abstract: The present disclosure relates to characterization of biological samples. By way of example, a biological sample may be contacted with a plurality of probes specific for targets in the sample, such as probes for immune markers and segmenting probes. Acquired image data of the sample may be used to segment the images into epithelial and stromal regions to characterize individual cells in the sample based on the binding of the probes. Further, the biological sample may be characterized by a heterogeneity of the characterized cells.
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公开(公告)号：US20160358326A1
公开(公告)日：2016-12-08
申请号：US14729982
申请日：2015-06-03
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brion Daryl Sarachan , John Frederick Graf , Anup Sood , Vidya Pundalik Kamath
CPC classification number: G06F17/30259 , G06F19/00 , G06F19/321
Abstract: Dynamic linking of pathway maps and cell maps is disclosed in certain embodiments. In such embodiments, the pathway maps are linked to spatially-localized regional nucleic acid data (e.g., sequence data), as opposed to non-spatially selected nucleic acid data. The pathway map and cell map data may be linked so that interactions results in changes or updates to the linked map, such as the selection or highlighting of cells exhibiting pathway map characteristics specified by a user of updating of node values or states to correspond to that of a cell or cells selected by the user.
Abstract translation: 在某些实施方案中公开了途径图和细胞图的动态连接。 在这样的实施方案中，与非空间选择的核酸数据相反，途径图连接到空间定位的区域核酸数据（例如序列数据）。 路径图和细胞图谱数据可以被链接，使得交互导致对链接的图的改变或更新，诸如显示由用户更新节点值或状态所指示的路径图特征的细胞的选择或突出显示，以对应于该 的用户选择的单元格或单元格。
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5.发明申请公开(公告)号：US20130332135A1
公开(公告)日：2013-12-12
申请号：US13967123
申请日：2013-08-14
Applicant: General Electric Company
Inventor： John Frederick Graf , Brion Daryl Sarachan , Mary Elizabeth Spilker
IPC: G06F19/00
CPC classification number: G09B23/28 , G06K9/6228 , G06T7/0012 , G06T2207/30004 , G16C99/00 , G16H50/50
Abstract: The quantitative evaluation of biomarker-probe activity is disclosed. In certain embodiments, the biomarker-probe activity may be quantified and analyzed using biodistributions generated using a model. In some embodiments, such biodistributions may be used to generate simulated images from which quantitative thresholds may be derived. In some embodiments, the quantitative thresholds may be used to analyze the biodistributions.
Abstract translation: 公开了生物标志物探针活性的定量评估。 在某些实施方案中，可以使用使用模型生成的生物分布来量化和分析生物标记探针活性。 在一些实施例中，这样的生物分布可以用于产生可以从其导出定量阈值的模拟图像。 在一些实施方案中，定量阈值可用于分析生物分布。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20130170728A1
公开(公告)日：2013-07-04
申请号：US13778576
申请日：2013-02-27
Applicant: General Electric Company
Inventor： Brion Daryl Sarachan , Thomas Paul Repoff , Colin Craig McCulloch , Fiona Mary Ginty , Megan Pearl Rothney , Zhengyu Pang
IPC: G06F19/18
CPC classification number: G06F19/18 , G06F19/24 , G06T7/11 , G06T2207/10056 , G06T2207/20221 , G06T2207/30024
Abstract: The invention relates generally to a process of analyzing and visualizing the expression of biomarkers in an individual cell wherein the cell is examined to develop patterns of expression by using a grouping algorithm, and a system to perform and display the analysis.
Abstract translation: 本发明一般涉及分析和可视化单个细胞中生物标志物的表达的方法，其中通过使用分组算法检查细胞以发展表达模式，以及执行和显示分析的系统。
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公开(公告)号：US09613254B1
公开(公告)日：2017-04-04
申请号：US14871667
申请日：2015-09-30
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brion Daryl Sarachan , John Frederick Graf , Vidya Pundalik Kamath
CPC classification number: G06K9/00147 , G06K9/00134 , G06K9/0014 , G06K9/3241 , G06K9/6215 , G06K9/6219 , G06K9/6224 , G06K9/6247
Abstract: The present disclosure relates to characterization of biological samples. By way of example, a biological sample may be contacted with a plurality of probes specific for targets in the sample, such as probes for immune markers and segmenting probes. Acquired image data of the sample may be used to segment the images into epithelial and stromal regions to characterize individual cells in the sample based on the binding of the probes. Further, the biological sample may be characterized by a heterogeneity of the characterized cells.
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公开(公告)号：US20160357906A1
公开(公告)日：2016-12-08
申请号：US14730037
申请日：2015-06-03
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brion Daryl Sarachan , John Frederick Graf
CPC classification number: G06F19/26 , C12Q1/6841 , G01N21/6456 , G06F19/20 , C12Q2543/10 , C12Q2563/107
Abstract: Identification of regions-of-interest within cell maps is disclosed. In certain embodiments, identification of the regions-of interest is based on the use of a plurality of biomarkers, which may be used to generate a multiplexed image of a tissue sample. Based on the identified regions, cells may be extracted and localized sequence data may be generated specific to the regions-of-interest.
Abstract translation: 公开了细胞图中感兴趣区域的识别。 在某些实施方案中，感兴趣区域的鉴定基于多个生物标志物的使用，其可用于产生组织样本的多路复用图像。 基于所识别的区域，可以提取单元，并且可以生成特定于感兴趣区域的局部序列数据。
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9.发明授权公开(公告)号：US08824769B2
公开(公告)日：2014-09-02
申请号：US13778576
申请日：2013-02-27
Applicant: General Electric Company
Inventor： Brion Daryl Sarachan , Thomas Paul Repoff , Colin Craig McCulloch , Fiona Mary Ginty , Megan Pearl Rothney , Zhengyu Pang
CPC classification number: G06F19/18 , G06F19/24 , G06T7/11 , G06T2207/10056 , G06T2207/20221 , G06T2207/30024
Abstract: The invention relates generally to a process of analyzing and visualizing the expression of biomarkers in an individual cell wherein the cell is examined to develop patterns of expression by using a grouping algorithm, and a system to perform and display the analysis.
Abstract translation: 本发明一般涉及分析和可视化单个细胞中生物标志物的表达的方法，其中通过使用分组算法检查细胞以发展表达模式，以及执行和显示分析的系统。
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公开(公告)号：US20130317844A1
公开(公告)日：2013-11-28
申请号：US13957132
申请日：2013-08-01
Applicant: General Electric Company
Inventor： Christopher Reynolds Hammond , Brion Daryl Sarachan , Matthew David Kelly , Rachel Susannah Midgley , John Michael Brady , Mark Robert Austin , David J. Kerr
IPC: G06F19/00
CPC classification number: G16H80/00 , G06F19/321 , G06Q50/22 , G16H40/20 , G16H50/20
Abstract: A method and system are provided for facilitating decision making, such as in a clinical setting. In accordance with this technique, a set of encoded guidelines are executed to identify information that may be used to generate patient management options. The information is acquired, if available. Based on the encoded guidelines and the acquired information, a set of patient management options are generated and provided to one or more reviewers for review and selection of a patient management option.
Abstract translation: 提供了一种用于促进决策的方法和系统，例如在临床环境中。 根据该技术，执行一组编码指南以识别可用于产生患者管理选项的信息。 获取信息（如果有）。 基于经编码的准则和所获取的信息，生成一组患者管理选项并将其提供给一个或多个审阅者以供审查和选择患者管理选项。
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