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    Photoactivated chemical bleaching of dyes using borates
    2.
    发明授权
    Photoactivated chemical bleaching of dyes using borates 有权

    公开(公告)号：US10101322B2

    公开(公告)日：2018-10-16

    申请号：US14621715

    申请日：2015-02-13

    Applicant: GENERAL ELECTRIC COMPANY

    Inventor： Arunkumar Natarajan ,  Anup Sood ,  Lakshmi Sireesha Kaanumalle ,  Christina Lowes

    IPC: G01N33/536 ,  G01N33/58 ,  G01N21/64 ,  G01N1/30

    Abstract: Methods comprising the use of photoactivated chemical bleaching for detecting multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The method further includes the steps of contacting the sample comprising the bound probe with a cationic or zwitterionic borate compound and irradiating the sample, thereby initiating a photoreaction that substantially inactivates the probe by photoactivated chemical bleaching. The method further includes the steps of binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The process of binding, observing and bleaching may be iteratively repeated.

    Borates for photoactivated chemical bleaching
    3.
    发明授权
    Borates for photoactivated chemical bleaching 有权

    公开(公告)号：US09708349B2

    公开(公告)日：2017-07-18

    申请号：US14621776

    申请日：2015-02-13

    Applicant: GENERAL ELECTRIC COMPANY

    Inventor： Arunkumar Natarajan ,  Anup Sood ,  Lakshmi Sireesha Kaanumalle

    IPC: C07F5/02 ,  C07F9/02

    CPC classification number: C07F5/02

    Abstract: A borate compound for use as photoinduced chemical bleaching reagent is disclosed having improved bleaching performance under certain conditions, compared to neutral borates. The compounds are comprised of Formula I; R1R2R3R4BXa   I where each R1, R2, and R3 and R4 is, independently, an alkyl, alkylaryl, or arylalkyl, with the proviso that at least one of R1, R2, and R3 and R4 is an alkyl group and at least two of R1, R2, R3 and R4 group is positively charged; X is an anion; and a equals 1, 2, or 3.

    Methods of analyzing an H and E stained biological sample
    5.
    发明授权
    Methods of analyzing an H and E stained biological sample 有权
    分析H和E染色生物样品的方法

    公开(公告)号：US09176032B2

    公开(公告)日：2015-11-03

    申请号：US13786747

    申请日：2013-03-06

    Applicant: General Electric Company

    Inventor： Anup Sood ,  Kevin Bernard Kenny ,  Arunkumar Natarajan ,  Lakshmi Sireesha Kaanumalle

    IPC: G01N33/53 ,  G01N33/532 ,  G01N33/533 ,  G01N21/76 ,  G01N1/30 ,  G01N33/58 ,  G01N21/64

    CPC classification number: G01N1/30 ,  G01N21/64 ,  G01N21/6428 ,  G01N33/582

    Abstract: Methods comprising the use probing multiple targets in a H&E stained biological sample are provided. The methods include the steps of providing a hematoxylin and eosin stained biological sample containing multiple targets, observing the sample, removing the hematoxylin and partially removing the eosin by washing the sample, contacting the sample with a borate salt, and irradiating the sample to remove the residual eosin fluorescence. The method further includes the optionally performing the additional steps of binding at least one probe to one or more targets to the sample, observing a signal from the probe and contacting the sample with a bleaching agent. The process of binding, observing and bleaching may be iteratively repeated.

    Abstract translation: 提供了包括在H＆E染色的生物样品中使用探测多个靶标的方法。 所述方法包括以下步骤：提供含有多个靶标的苏木精和伊红染色的生物样品，观察样品，除去苏木精并通过洗涤样品部分除去曙红，使样品与硼酸盐接触，并照射样品以除去 残余曙红荧光。 该方法还包括任选地执行将至少一个探针结合至样品的一个或多个靶的附加步骤，观察来自探针的信号并使样品与漂白剂接触。 结合，观察和漂白的过程可以迭代地重复。

    METHODS OF ANALYZING AN H&E STAINED BIOLOGICAL SAMPLE
    6.
    发明申请
    METHODS OF ANALYZING AN H&E STAINED BIOLOGICAL SAMPLE 有权
    分析H＆E污染生物样品的方法

    公开(公告)号：US20130178392A1

    公开(公告)日：2013-07-11

    申请号：US13786747

    申请日：2013-03-06

    Applicant: General Electric Company

    Inventor： Anup Sood ,  Kevin Bernard Kenny ,  Arunkumar Natarajan ,  Lakshmi Sireesha Kaanumalle

    IPC: G01N1/30

    CPC classification number: G01N1/30 ,  G01N21/64 ,  G01N21/6428 ,  G01N33/582

    Abstract: Methods comprising the use probing multiple targets in a H&E stained biological sample are provided. The methods include the steps of providing a hematoxylin and eosin stained biological sample containing multiple targets, observing the sample, removing the hematoxylin and partially removing the eosin by washing the sample, contacting the sample with a borate salt, and irradiating the sample to remove the residual eosin fluorescence. The method further includes the optionally performing the additional steps of binding at least one probe to one or more targets to the sample ,observing a signal from the probe and contacting the sample with a bleaching agent. The process of binding, observing and bleaching may be iteratively repeated.

    Abstract translation: 提供了包括在H＆E染色的生物样品中使用探测多个靶标的方法。 所述方法包括以下步骤：提供含有多个靶标的苏木精和伊红染色的生物样品，观察样品，除去苏木精并通过洗涤样品部分除去曙红，使样品与硼酸盐接触，并照射样品以除去 残余曙红荧光。 该方法还包括任选地执行将至少一个探针结合至样品的一个或多个靶的附加步骤，观察来自探针的信号并使样品与漂白剂接触。 结合，观察和漂白的过程可以迭代地重复。

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