公开(公告)号：US20190060347A1

公开(公告)日：2019-02-28

申请号：US16016963

申请日：2018-06-25

Applicant: General Electric Company

Inventor： Anup Sood ,  Lisa Anne Lowery ,  Praveena Mohan ,  James Edward Rothman ,  John Donald Burczak ,  Hae Won Lim

IPC: A61K31/713 ,  A61K41/00 ,  A61K47/64 ,  A61K47/54 ,  C12N15/113 ,  A61K47/06 ,  A61M37/00 ,  A61K9/00 ,  C12N15/11 ,  C12N15/87 ,  A61K47/69

Abstract: The present invention relates to a microbubble complex comprising a microbubble having an outer shell comprising a mixture of native and denatured albumin encapsulating a perfluorocarbon gas, a therapeutic agent, a bifunctional linker having one end attached to the therapeutic agent and the other attached to a ligand and wherein the ligand is bound to the other shell of the microbubble through hydrophobic interactions. Also included are methods for delivering the aforementioned microbubble complex to a tissue target.

公开(公告)号：US11007212B2

公开(公告)日：2021-05-18

申请号：US16016963

申请日：2018-06-25

Applicant: General Electric Company

Inventor： Anup Sood ,  Lisa Anne Lowery ,  Praveena Mohan ,  James Edward Rothman ,  John Donald Burczak ,  Hae Won Lim

IPC: A61K47/64 ,  A61K31/713 ,  A61K47/54 ,  A61K47/69 ,  A61K41/00 ,  C12N15/87 ,  C12N15/11 ,  A61K9/00 ,  A61K47/06 ,  A61M37/00 ,  C12N15/113

Abstract: The present invention relates to a microbubble complex comprising a microbubble having an outer shell comprising a mixture of native and denatured albumin encapsulating a perfluorocarbon gas, a therapeutic agent, a bifunctional linker having one end attached to the therapeutic agent and the other attached to a ligand and wherein the ligand is bound to the other shell of the microbubble through hydrophobic interactions. Also included are methods for delivering the aforementioned microbubble complex to a tissue target.

公开(公告)号：US20180001231A1

公开(公告)日：2018-01-04

申请号：US15209411

申请日：2016-07-13

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Christopher Michael Puleo ,  Craig Patrick Galligan ,  Gregory Andrew Grossmann ,  Erik Leeming Kvam ,  Robert Scott Duthie ,  Kenneth Wayne Rigby ,  Paul Michael Smigelski, JR. ,  Victoria Eugenia Cotero ,  Jason William Castle ,  John Donald Burczak ,  James Edward Rothman

IPC: B01D21/00 ,  G01N1/40 ,  G01N33/49 ,  B01L3/00

Abstract: A separation device, system and associated method are provided herein for separation of particulates form a base fluid. The separation device comprises a first microchannel comprising a fluid inlet and a mesofluidic collection chamber. The mesofluidic collection chamber has a first side and a second side, wherein the mesofluidic collection chamber is operatively coupled to the first microchannel on the first side, and wherein the mesofluidic collection chamber comprises a first fluid outlet at the second side, such that the fluid inlet, first microchannel, and first fluid outlet are in fluidic communication via the mesofluidic collection chamber.

公开(公告)号：US20170007636A1

公开(公告)日：2017-01-12

申请号：US15219419

申请日：2016-07-26

Applicant: General Electric Company

Inventor： Praveena Mohan ,  Anup Sood ,  James Edward Rothman ,  John Donald Burczak ,  Hae Won Lim ,  Lisa Anne Lowery

IPC: A61K31/713 ,  C12N15/113 ,  A61M37/00 ,  A61K47/48 ,  A61K47/06 ,  A61K41/00 ,  A61K9/00

CPC classification number: A61K31/713 ,  A61K9/0019 ,  A61K41/0028 ,  A61K47/06 ,  A61K47/554 ,  A61K47/64 ,  A61K47/643 ,  A61K47/6925 ,  A61M37/0092 ,  A61M2037/0007 ,  C12N15/111 ,  C12N15/1136 ,  C12N15/87 ,  C12N2310/14 ,  C12N2310/3515 ,  C12N2320/32

Abstract: The present invention relates to a microbubble complex comprising a microbubble having an outer shell comprising a mixture of native and denatured albumin encapsulating a perfluorocarbon gas, a therapeutic agent, a bifunctional linker having one end attached to the therapeutic agent and the other attached to a ligand and wherein the ligand is bound to the other shell of the microbubble through hydrophobic interactions. Also included are methods for delivering the aforementioned microbubble complex to a tissue target.

Abstract translation: 本发明涉及一种微泡复合物，其包含具有外壳的微泡，所述微泡包含天然和包封全氟化碳气体的变性白蛋白的混合物，治疗剂，具有连接于治疗剂的一端的双功能连接体，另一端连接于配体 并且其中配体通过疏水相互作用结合到微泡的另一个壳体。 还包括用于将上述微泡复合物递送到组织靶的方法。

公开(公告)号：US10518196B2

公开(公告)日：2019-12-31

申请号：US15209411

申请日：2016-07-13

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Christopher Michael Puleo ,  Craig Patrick Galligan ,  Gregory Andrew Grossman ,  Erik Leeming Kvam ,  Robert Scott Duthie ,  Kenneth Wayne Rigby ,  Paul Michael Smigelski, Jr. ,  Victoria Eugenia Cotero ,  Jason William Castle ,  John Donald Burczak ,  James Edward Rothman

IPC: B01D21/00 ,  B01D21/24 ,  G01N33/49 ,  B01L3/00 ,  G01N1/40 ,  C12M1/12 ,  C12M1/26 ,  B01D17/02 ,  B01D21/02 ,  C12M1/00 ,  C02F1/48 ,  C02F1/44 ,  C02F101/32

Abstract: A separation device, system and associated method are provided herein for separation of particulates form a base fluid. The separation device comprises a first microchannel comprising a fluid inlet and a mesofluidic collection chamber. The mesofluidic collection chamber has a first side and a second side, wherein the mesofluidic collection chamber is operatively coupled to the first microchannel on the first side, and wherein the mesofluidic collection chamber comprises a first fluid outlet at the second side, such that the fluid inlet, first microchannel, and first fluid outlet are in fluidic communication via the mesofluidic collection chamber.

公开(公告)号：US10004760B2

公开(公告)日：2018-06-26

申请号：US15219419

申请日：2016-07-26

Applicant: General Electric Company

Inventor： Praveena Mohan ,  Anup Sood ,  James Edward Rothman ,  John Donald Burczak ,  Hae Won Lim ,  Lisa Anne Lowery

IPC: A61K31/713 ,  A61K41/00 ,  C12N15/87 ,  C12N15/11 ,  A61K9/00 ,  A61K47/06 ,  A61M37/00 ,  C12N15/113 ,  A61K47/54 ,  A61K47/64 ,  A61K47/69

CPC classification number: A61K31/713 ,  A61K9/0019 ,  A61K41/0028 ,  A61K47/06 ,  A61K47/554 ,  A61K47/64 ,  A61K47/643 ,  A61K47/6925 ,  A61M37/0092 ,  A61M2037/0007 ,  C12N15/111 ,  C12N15/1136 ,  C12N15/87 ,  C12N2310/14 ,  C12N2310/3515 ,  C12N2320/32

Abstract: The present invention relates to a microbubble complex comprising a microbubble having an outer shell comprising a mixture of native and denatured albumin encapsulating a perfluorocarbon gas, a therapeutic agent, a bifunctional linker having one end attached to the therapeutic agent and the other attached to a ligand and wherein the ligand is bound to the other shell of the microbubble through hydrophobic interactions. Also included are methods for delivering the aforementioned microbubble complex to a tissue target.