公开(公告)号：US20240360507A1

公开(公告)日：2024-10-31

申请号：US18684929

申请日：2021-12-30

Applicant: GENESPECTOR S.R.O.

Inventor： Stanislav KMOCH ,  Lenka PIHEROVA ,  Hana HARTMANNOVA ,  Michal POHLUDKA ,  Martin RADINA

IPC: C12Q1/6876 ,  C12Q1/6851

CPC classification number: C12Q1/6876 ,  C12Q1/6851 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: Method for predicting a severity of an infectious disease and biomarker for use in carrying out the method and monitoring a therapy of an infectious disease using an RT-qPCR method, while the method is being performed on a nasopharyngeal swab sample determining the amount of serum amyloid A mRNA, preferably SAA1, and the amount of serum amyloid A mRNA is normalized to the amount of mRNA of a constitutively expressed gene, which is preferably UBC. Based on the determined normalized value of the amount of SAA1 mRNA in the sample, the severity of the course of an infectious disease, which may be of viral, bacterial, or fungal origin, is predicted, and the effectiveness of a therapy of the given disease is further monitored.