公开(公告)号：US20190178799A1

公开(公告)日：2019-06-13

申请号：US16205256

申请日：2018-11-30

Applicant: GENEWAVE

Inventor： Claude WEISBUCH ,  Lucio MARTINELLI ,  Henri BENISTY ,  Christof SCHAFAUER ,  Gabriel SAGARZAZU ,  Thierry GACOIN ,  Mélanie BEDU

IPC: G01N21/64 ,  G01N21/47 ,  G01N21/77

Abstract: A biochip device comprising a substrate constituted by at least one plate of material forming a multimode planar waveguide and carrying chromophore elements suitable for emitting fluorescence in response to excitation by guided waves having an evanescent portion, the device being characterized in that it includes coupling means for coupling excitation light with the waveguide in the form of guided waves, the coupling means being substantially non-directional.

公开(公告)号：US20190257756A1

公开(公告)日：2019-08-22

申请号：US16398890

申请日：2019-04-30

Applicant: GENEWAVE

Inventor： Claude WEISBUCH ,  Lucio MARTINELLI ,  Henri BENISTY ,  Christof SCHAFAUER ,  Gabriel SAGARZAZU ,  Thierry GACOIN ,  Mélanie BEDU

IPC: G01N21/64 ,  G01N21/47 ,  G01N21/77

Abstract: A biochip device comprising a substrate constituted by at least one plate of material forming a multimode planar waveguide and carrying chromophore elements suitable for emitting fluorescence in response to excitation by guided waves having an evanescent portion, the device being characterized in that it includes coupling means for coupling excitation light with the waveguide in the form of guided waves, the coupling means being substantially non-directional.

公开(公告)号：US20220381692A1

公开(公告)日：2022-12-01

申请号：US17818637

申请日：2022-08-09

Applicant: GENEWAVE

Inventor： Claude WEISBUCH ,  Lucio MARTINELLI ,  Henri BENISTY ,  Christof SCHAFAUER ,  Gabriel SAGARZAZU ,  Thierry GACOIN ,  Mélanie BEDU

IPC: G01N21/64 ,  G01N21/47 ,  G01N21/77 ,  G02B5/00 ,  G02B5/02 ,  G02B6/14 ,  G02B6/124

Abstract: A biochip device includes a waveguide, chromophore elements, a diffusing structure, and a sloping surface. The chromophore elements are disposed on a portion of the waveguide and are configured to emit fluorescence in response to excitation by guided light waves transmitted by the waveguide. The diffusing structure is configured to generate guided light waves in the waveguide when illuminated. The sloping surface is sloped relative to a plane of the waveguide and is configured to direct excitation light into the waveguide, and the sloping surface and the waveguide are configured to deflect the excitation light to the diffusing structure to generate guided light waves within the waveguide. The sloping surface may be a face of a prism attached to or integrated with the waveguide, or the sloping surface may be a chamfer formed at an edge of the waveguide.

公开(公告)号：US20220381691A1

公开(公告)日：2022-12-01

申请号：US17818612

申请日：2022-08-09

Applicant: GENEWAVE

Inventor： Claude WEISBUCH ,  Lucio MARTINELLI ,  Henri BENISTY ,  Christof SCHAFAUER ,  Gabriel SAGARZAZU ,  Thierry GACOIN ,  Mélanie BEDU

IPC: G01N21/64 ,  G02B6/42 ,  B01L3/00

Abstract: A biochip device includes a stratified structure, a light coupler, and an optofluidic portion. The stratified structure includes a top layer having a refractive index n1, a bottom layer having a refractive index n3, and an intermediate layer between the top and bottom layers having a refractive index n2. The light coupler optically couples a light source and the top layer to generate waves that are guided in a plurality of directions inside the top layer. The optofluidic portion is supported on a surface of the top layer and includes a hybridizing chamber containing a hybridizing solution and pads supported on the surface of the top layer and situated within the hybridizing chamber. Probe molecules are deposited on the pads. The refractive index n2 of the intermediate layer is greater than or equal to a highest index of refraction of the hybridizing chamber and the hybridizing solution.