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    BIOCHIP DEVICE
    2.
    发明申请
    BIOCHIP DEVICE 有权

    公开(公告)号：US20220381692A1

    公开(公告)日：2022-12-01

    申请号：US17818637

    申请日：2022-08-09

    Applicant: GENEWAVE

    Inventor： Claude WEISBUCH ,  Lucio MARTINELLI ,  Henri BENISTY ,  Christof SCHAFAUER ,  Gabriel SAGARZAZU ,  Thierry GACOIN ,  Mélanie BEDU

    IPC: G01N21/64 ,  G01N21/47 ,  G01N21/77 ,  G02B5/00 ,  G02B5/02 ,  G02B6/14 ,  G02B6/124

    Abstract: A biochip device includes a waveguide, chromophore elements, a diffusing structure, and a sloping surface. The chromophore elements are disposed on a portion of the waveguide and are configured to emit fluorescence in response to excitation by guided light waves transmitted by the waveguide. The diffusing structure is configured to generate guided light waves in the waveguide when illuminated. The sloping surface is sloped relative to a plane of the waveguide and is configured to direct excitation light into the waveguide, and the sloping surface and the waveguide are configured to deflect the excitation light to the diffusing structure to generate guided light waves within the waveguide. The sloping surface may be a face of a prism attached to or integrated with the waveguide, or the sloping surface may be a chamfer formed at an edge of the waveguide.

    BIOCHIP DEVICE
    3.
    发明申请
    BIOCHIP DEVICE 有权

    公开(公告)号：US20220381691A1

    公开(公告)日：2022-12-01

    申请号：US17818612

    申请日：2022-08-09

    Applicant: GENEWAVE

    Inventor： Claude WEISBUCH ,  Lucio MARTINELLI ,  Henri BENISTY ,  Christof SCHAFAUER ,  Gabriel SAGARZAZU ,  Thierry GACOIN ,  Mélanie BEDU

    IPC: G01N21/64 ,  G02B6/42 ,  B01L3/00

    Abstract: A biochip device includes a stratified structure, a light coupler, and an optofluidic portion. The stratified structure includes a top layer having a refractive index n1, a bottom layer having a refractive index n3, and an intermediate layer between the top and bottom layers having a refractive index n2. The light coupler optically couples a light source and the top layer to generate waves that are guided in a plurality of directions inside the top layer. The optofluidic portion is supported on a surface of the top layer and includes a hybridizing chamber containing a hybridizing solution and pads supported on the surface of the top layer and situated within the hybridizing chamber. Probe molecules are deposited on the pads. The refractive index n2 of the intermediate layer is greater than or equal to a highest index of refraction of the hybridizing chamber and the hybridizing solution.

    MICROFLUIDIC CARTRIDGE FOR MOLECULAR DIAGNOSIS, DOCKING STATION USING A MICROFLUIDIC CARTRIDGE, AND PROCESS FOR ANALYZING A BIOLOGICAL SAMPLE
    6.
    发明申请
    MICROFLUIDIC CARTRIDGE FOR MOLECULAR DIAGNOSIS, DOCKING STATION USING A MICROFLUIDIC CARTRIDGE, AND PROCESS FOR ANALYZING A BIOLOGICAL SAMPLE 审中-公开
    用于分子诊断的微流控盒，使用微流控盒的阻塞站和分析生物样品的方法

    公开(公告)号：US20160375438A1

    公开(公告)日：2016-12-29

    申请号：US15039860

    申请日：2014-11-27

    Applicant: GENEWAVE

    Inventor： Yann MARCY ,  Marc ARTIGUE ,  Quentin LE MASNE ,  Kevin MARQ

    IPC: B01L3/00 ,  C12Q1/68 ,  B01L9/00

    Abstract: A microfluidic cartridge for detecting one nucleic acid of a sample, including a plurality of functional volumes split into functional areas and a fluidic network of microchannels. At least three functional areas are fluidly connected to a central distribution hub of fluids by one or more hub-connected microchannels, the central distribution hub being capable of pumping and injecting fluids from a first functional area to a second functional area by passing through the central distribution hub; and at least three valves of hub-connected microchannels are arranged so that the at least three valves are adapted to be actuated mechanically by a single external cam-driven actuator. A docking station using such a microfluidic cartridge and a process for analyzing a biological sample involving a docking station and a microfluidic cartridge are also described.

    Abstract translation: 一种用于检测样品的一个核酸的微流控盒，包括分离成功能区域的多个功能体积和微通道的流体网络。 至少三个功能区域通过一个或多个轮毂连接的微通道流体地连接到流体的中心分配轮毂，中心分配轮毂能够通过穿过中心部分的通道从第一功能区域向第二功能区域泵送和注入流体 配电枢纽; 并且至少三个阀毂连接的微通道被布置成使得至少三个阀适于由单个外部凸轮驱动致动器机械地致动。 还描述了使用这种微流控盒的对接站和用于分析涉及对接站和微流控盒的生物样品的方法。

    Device for supporting chromophore elements
    9.
    再颁专利
    Device for supporting chromophore elements 有权
    用于支持发色团元件的装置

    公开(公告)号：USRE46165E1

    公开(公告)日：2016-09-27

    申请号：US14799092

    申请日：2015-07-14

    Applicant: Genewave

    Inventor： Claude Weisbuch

    IPC: G01N21/01 ,  G01N33/53 ,  G01N21/64

    CPC classification number: G01N21/648 ,  G01N21/6458 ,  G01N21/7703 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6471 ,  G02B6/42

    Abstract: A device for supporting chromophore elements suitable for emitting fluorescence in response to light excitation, the device comprising a substrate having a surface layer carrying the chromophore elements, forming a planar waveguide, and containing photoluminescent constituents which emit guided luminescence at the excitation wavelength(s) of the chromophore elements when they are excited by primary excitation light illuminating the surface layer. The invention is particularly applicable to biochip type devices.

    Abstract translation: 一种用于支持适于发射响应于光激发的荧光的发色元件的装置，所述装置包括具有承载发色团元件的表面层的基底，形成平面波导，并且包含以激发波长发射引导发光的光致发光成分， 的发色团元素当它们被照射表面层的主激发光激发时。 本发明特别适用于生物芯片型装置。

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