公开(公告)号：US20210380686A1

公开(公告)日：2021-12-09

申请号：US17306509

申请日：2021-05-03

Applicant: Genzyme Corporation

Inventor： Yunxiang Zhu ,  Jozsef Karman ,  Ronnie Wei ,  Canwen Jiang ,  Seng Cheng

IPC: C07K16/28 ,  C07K14/74 ,  C07K14/47 ,  C07K14/705

Abstract: The present invention provides a bispecific biologic comprising a ligand specific for CTLA-4 and a ligand specific for a pMHC complex.

公开(公告)号：US20250002578A1

公开(公告)日：2025-01-02

申请号：US18741190

申请日：2024-06-12

Applicant: GENZYME CORPORATION

Inventor： Yunxiang Zhu ,  Jozsef Karman ,  Ronnie Wei ,  Canwen Jiang ,  Seng Cheng

IPC: C07K16/28 ,  C07K14/47 ,  C07K14/705 ,  C07K14/74

Abstract: The present invention provides a bispecific biologic comprising a ligand specific for CTLA-4 and a ligand specific for a pMHC complex.

公开(公告)号：US20180030134A1

公开(公告)日：2018-02-01

申请号：US15788433

申请日：2017-10-19

Applicant: Genzyme Corporation

Inventor： Yunxiang Zhu ,  Jozsef Karman ,  Ronnie Wei ,  Canwen Jiang ,  Seng Cheng

IPC: C07K16/28 ,  C07K14/47 ,  C07K14/705 ,  C07K14/74

Abstract: The present invention provides a bispecific biologic comprising a ligand specific for CTLA-4 and a ligand specific for a pMHC complex.

公开(公告)号：US12043665B2

公开(公告)日：2024-07-23

申请号：US17306509

申请日：2021-05-03

Applicant: Genzyme Corporation

Inventor： Yunxiang Zhu ,  Jozsef Karman ,  Ronnie Wei ,  Canwen Jiang ,  Seng Cheng

IPC: C07K16/28 ,  A61K38/17 ,  A61K39/395 ,  A61P37/06 ,  C07K14/47 ,  C07K14/705 ,  C07K14/74

CPC classification number: C07K16/2803 ,  C07K14/47 ,  C07K14/70532 ,  C07K14/70539 ,  C07K2319/00

Abstract: The present invention provides a bispecific biologic comprising a ligand specific for CTLA-4 and a ligand specific for a pMHC complex.

公开(公告)号：US11028170B2

公开(公告)日：2021-06-08

申请号：US15788433

申请日：2017-10-19

Applicant: Genzyme Corporation

Inventor： Yunxiang Zhu ,  Jozsef Karman ,  Ronnie Wei ,  Canwen Jiang ,  Seng Cheng

IPC: C07K14/47 ,  C07K14/705 ,  C07K19/00 ,  A61K38/17 ,  A61K39/395 ,  C07K16/28 ,  C07K14/74

Abstract: The present invention provides a bispecific biologic comprising a ligand specific for CTLA-4 and a ligand specific for a pMHC complex.