公开(公告)号：US20180105505A1

公开(公告)日：2018-04-19

申请号：US15573183

申请日：2016-05-12

Applicant: GEORGETOWN UNIVERSITY

Inventor： Milton L. Brown ,  Yali Kong ,  Jacqueline Smith ,  Kan Wang ,  Shujie Hou

IPC: C07D311/02 ,  C07C271/28 ,  C07C321/14 ,  C07C69/017 ,  C07C69/003 ,  A61K47/69 ,  A61P35/00 ,  G01N21/64

CPC classification number: C07D311/02 ,  A61K31/352 ,  A61K47/6957 ,  A61P35/00 ,  C07C69/003 ,  C07C69/017 ,  C07C271/28 ,  C07C321/14 ,  C07D311/18 ,  C07D311/58 ,  G01N21/64

Abstract: A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject.

公开(公告)号：US10023551B2

公开(公告)日：2018-07-17

申请号：US15573183

申请日：2016-05-12

Applicant: GEORGETOWN UNIVERSITY

Inventor： Milton L. Brown ,  Yali Kong ,  Jacqueline Smith ,  Kan Wang ,  Shujie Hou

IPC: C07D311/58 ,  C07D311/02 ,  A61P35/00 ,  G01N21/64 ,  A61K47/69 ,  C07C321/14 ,  C07C69/017 ,  C07C69/003 ,  C07C271/28

Abstract: A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject.