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公开(公告)号：US11311526B2
公开(公告)日：2022-04-26
申请号：US16089794
申请日：2017-03-31
Inventor： Milton L. Brown , Yali Kong , Courtney Houchen , Sripathi M. Sureban , Parthasarathy Chandrakesan
IPC: A61K31/454 , A61P39/00 , A61K31/4184
Abstract: Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.
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公开(公告)号：US20200306234A1
公开(公告)日：2020-10-01
申请号：US16089794
申请日：2017-03-31
Inventor： Milton L. Brown , Yali Kong , Courtney Houchen , Sripathi M. Sureban , Parthasarathy Chandrakesan
IPC: A61K31/454 , A61K31/4184 , A61P39/00
Abstract: Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein Z is —O—or —N(H)—.
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公开(公告)号：US12246011B2
公开(公告)日：2025-03-11
申请号：US18207447
申请日：2023-06-08
Inventor： Milton L. Brown , Yali Kong , Courtney Houchen , Sripathi M. Sureban , Parthasarathy Chandrakesan
IPC: A61K31/454 , A61K31/4184 , A61P39/00
Abstract: Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.
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公开(公告)号：US20180105505A1
公开(公告)日：2018-04-19
申请号：US15573183
申请日：2016-05-12
Applicant: GEORGETOWN UNIVERSITY
Inventor： Milton L. Brown , Yali Kong , Jacqueline Smith , Kan Wang , Shujie Hou
IPC: C07D311/02 , C07C271/28 , C07C321/14 , C07C69/017 , C07C69/003 , A61K47/69 , A61P35/00 , G01N21/64
CPC classification number: C07D311/02 , A61K31/352 , A61K47/6957 , A61P35/00 , C07C69/003 , C07C69/017 , C07C271/28 , C07C321/14 , C07D311/18 , C07D311/58 , G01N21/64
Abstract: A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject.
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公开(公告)号：US09714222B2
公开(公告)日：2017-07-25
申请号：US15040840
申请日：2016-02-10
Applicant: GEORGETOWN UNIVERSITY
Inventor： Jeffrey A. Toretsky , Milton Lang Brown , Perrer N. Tosso , Aykut Uren , Yali Kong
IPC: C07D209/38 , C07D209/34
CPC classification number: C07D209/38 , C07D209/34
Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.
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Patent Agency Ranking
公开(公告)号：US11672789B2
公开(公告)日：2023-06-13
申请号：US17728485
申请日：2022-04-25
Inventor： Milton L. Brown , Yali Kong , Courtney Houchen , Sripathi M. Sureban , Parthasarathy Chandrakesan
IPC: A61K31/454 , A61P39/00 , A61K31/4184
CPC classification number: A61K31/454 , A61K31/4184 , A61P39/00
Abstract: Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I
or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.-
公开(公告)号：US20160159741A1
公开(公告)日：2016-06-09
申请号：US15040840
申请日：2016-02-10
Applicant: GEORGETOWN UNIVERSITY
Inventor： Jeffrey A. Toretsky , Milton Lang Brown , Perrer N. Tosso , Aykut Uren , Yali Kong
IPC: C07D209/38
CPC classification number: C07D209/38 , C07D209/34
Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.
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8.发明授权公开(公告)号：US09290449B2
公开(公告)日：2016-03-22
申请号：US14388671
申请日：2013-04-11
Applicant: GEORGETOWN UNIVERSITY
Inventor： Jeffrey A. Toretsky , Milton Lang Brown , Perrer N. Tosso , Aykut Uren , Yali Kong
IPC: C07D209/38 , C07D209/34
CPC classification number: C07D209/38 , C07D209/34
Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.
Abstract translation: 提供了与EWS-FLI1蛋白抑制剂有关的化合物，组合物和方法。 该化合物可用于治疗包括尤文氏肉瘤肿瘤家族在内的癌症。
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公开(公告)号：US20150329488A1
公开(公告)日：2015-11-19
申请号：US14696005
申请日：2015-04-24
Applicant: Georgetown University
Inventor： Jeffrey A. Toretsky , Aykut Uren , Milton Lang Brown , Yali Kong
IPC: C07D209/38 , A61K45/06 , A61K31/404
CPC classification number: C07D209/38 , A61K31/404 , A61K38/00 , A61K45/06 , C07D401/06 , C07K7/06 , C07K7/08
Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
Abstract translation: 提供了作为EWS-FLI1蛋白抑制剂的肽和化合物。 肽和化合物可用于治疗尤文氏肉瘤的肿瘤家族。 还提供了制备化合物的方法和鉴定EWS-FLI1蛋白抑制剂的测定法。
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10.发明申请公开(公告)号：US20150051260A1
公开(公告)日：2015-02-19
申请号：US14388671
申请日：2013-04-11
Applicant: GEORGETOWN UNIVERSITY
Inventor： Jeffrey A. Toretsky , Milton Lang Brown , Perrer N. Tosso , Aykut Uren , Yali Kong
IPC: C07D209/38 , C07D209/34
CPC classification number: C07D209/38 , C07D209/34
Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.
Abstract translation: 提供了与EWS-FLI1蛋白抑制剂有关的化合物，组合物和方法。 该化合物可用于治疗包括尤文氏肉瘤肿瘤家族在内的癌症。
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