公开(公告)号：US11311526B2

公开(公告)日：2022-04-26

申请号：US16089794

申请日：2017-03-31

申请人： Georgetown University ,  The Board of Regents of the University of Oklahoma

发明人： Milton L. Brown ,  Yali Kong ,  Courtney Houchen ,  Sripathi M. Sureban ,  Parthasarathy Chandrakesan

IPC分类号： A61K31/454 ,  A61P39/00 ,  A61K31/4184

摘要： Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.

公开(公告)号：US20200306234A1

公开(公告)日：2020-10-01

申请号：US16089794

申请日：2017-03-31

申请人： Georgetown University ,  The Board of Regents of the University of Oklahoma

发明人： Milton L. Brown ,  Yali Kong ,  Courtney Houchen ,  Sripathi M. Sureban ,  Parthasarathy Chandrakesan

IPC分类号： A61K31/454 ,  A61K31/4184 ,  A61P39/00

摘要： Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein Z is —O—or —N(H)—.

公开(公告)号：US20180105505A1

公开(公告)日：2018-04-19

申请号：US15573183

申请日：2016-05-12

申请人： GEORGETOWN UNIVERSITY

发明人： Milton L. Brown ,  Yali Kong ,  Jacqueline Smith ,  Kan Wang ,  Shujie Hou

IPC分类号： C07D311/02 ,  C07C271/28 ,  C07C321/14 ,  C07C69/017 ,  C07C69/003 ,  A61K47/69 ,  A61P35/00 ,  G01N21/64

CPC分类号： C07D311/02 ,  A61K31/352 ,  A61K47/6957 ,  A61P35/00 ,  C07C69/003 ,  C07C69/017 ,  C07C271/28 ,  C07C321/14 ,  C07D311/18 ,  C07D311/58 ,  G01N21/64

摘要： A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject.

公开(公告)号：US09714222B2

公开(公告)日：2017-07-25

申请号：US15040840

申请日：2016-02-10

申请人： GEORGETOWN UNIVERSITY

发明人： Jeffrey A. Toretsky ,  Milton Lang Brown ,  Perrer N. Tosso ,  Aykut Uren ,  Yali Kong

IPC分类号： C07D209/38 ,  C07D209/34

CPC分类号： C07D209/38 ,  C07D209/34

摘要： Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.

公开(公告)号：US11672789B2

公开(公告)日：2023-06-13

申请号：US17728485

申请日：2022-04-25

申请人： Georgetown University ,  The Board of Regents of the University of Oklahoma

发明人： Milton L. Brown ,  Yali Kong ,  Courtney Houchen ,  Sripathi M. Sureban ,  Parthasarathy Chandrakesan

IPC分类号： A61K31/454 ,  A61P39/00 ,  A61K31/4184

CPC分类号： A61K31/454 ,  A61K31/4184 ,  A61P39/00

摘要： Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I




or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.

公开(公告)号：US20160159741A1

公开(公告)日：2016-06-09

申请号：US15040840

申请日：2016-02-10

申请人： GEORGETOWN UNIVERSITY

发明人： Jeffrey A. Toretsky ,  Milton Lang Brown ,  Perrer N. Tosso ,  Aykut Uren ,  Yali Kong

IPC分类号： C07D209/38

CPC分类号： C07D209/38 ,  C07D209/34

摘要： Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.

公开(公告)号：US09290449B2

公开(公告)日：2016-03-22

申请号：US14388671

申请日：2013-04-11

申请人： GEORGETOWN UNIVERSITY

发明人： Jeffrey A. Toretsky ,  Milton Lang Brown ,  Perrer N. Tosso ,  Aykut Uren ,  Yali Kong

IPC分类号： C07D209/38 ,  C07D209/34

CPC分类号： C07D209/38 ,  C07D209/34

摘要： Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.

摘要翻译： 提供了与EWS-FLI1蛋白抑制剂有关的化合物，组合物和方法。 该化合物可用于治疗包括尤文氏肉瘤肿瘤家族在内的癌症。

公开(公告)号：US20150329488A1

公开(公告)日：2015-11-19

申请号：US14696005

申请日：2015-04-24

申请人： Georgetown University

发明人： Jeffrey A. Toretsky ,  Aykut Uren ,  Milton Lang Brown ,  Yali Kong

IPC分类号： C07D209/38 ,  A61K45/06 ,  A61K31/404

CPC分类号： C07D209/38 ,  A61K31/404 ,  A61K38/00 ,  A61K45/06 ,  C07D401/06 ,  C07K7/06 ,  C07K7/08

摘要： Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.

摘要翻译： 提供了作为EWS-FLI1蛋白抑制剂的肽和化合物。 肽和化合物可用于治疗尤文氏肉瘤的肿瘤家族。 还提供了制备化合物的方法和鉴定EWS-FLI1蛋白抑制剂的测定法。

公开(公告)号：US20150051260A1

公开(公告)日：2015-02-19

申请号：US14388671

申请日：2013-04-11

申请人： GEORGETOWN UNIVERSITY

发明人： Jeffrey A. Toretsky ,  Milton Lang Brown ,  Perrer N. Tosso ,  Aykut Uren ,  Yali Kong

IPC分类号： C07D209/38 ,  C07D209/34

CPC分类号： C07D209/38 ,  C07D209/34

摘要： Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.

摘要翻译： 提供了与EWS-FLI1蛋白抑制剂有关的化合物，组合物和方法。 该化合物可用于治疗包括尤文氏肉瘤肿瘤家族在内的癌症。

公开(公告)号：US20230310407A1

公开(公告)日：2023-10-05

申请号：US18207447

申请日：2023-06-08

申请人： Georgetown University ,  The Board of Regents of the University of Oklahoma

发明人： Milton L. Brown ,  Yali Kong ,  Courtney Houchen ,  Sripathi M. Sureban ,  Parthasarathy Chandrakesan

IPC分类号： A61K31/454 ,  A61P39/00 ,  A61K31/4184

CPC分类号： A61K31/454 ,  A61P39/00 ,  A61K31/4184

摘要： Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I




or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.