公开(公告)号：US10806725B2

公开(公告)日：2020-10-20

申请号：US15155258

申请日：2016-05-16

Applicant: GEORGETOWN UNIVERSITY

Inventor： Sivanesan Dakshanamurthy ,  Milton L. Brown ,  Robert Clarke ,  Ayesha N. Shajahan-Haq ,  Jacqueline Smith

IPC: A61K31/4439 ,  A61K31/426 ,  A61K31/427 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/04 ,  C07D417/14 ,  A61K31/41 ,  C07D213/32 ,  A61K31/444 ,  A61K45/06

Abstract: Small molecule inhibitors of XBP1 splicing by IRE1α are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

公开(公告)号：US20170007588A1

公开(公告)日：2017-01-12

申请号：US15155258

申请日：2016-05-16

Applicant: GEORGETOWN UNIVERSITY

Inventor： Sivanesan Dakshanamurthy ,  Milton L. Brown ,  Robert Clarke ,  Ayesha N. Shajahan-Haq ,  Jacqueline Smith

IPC: A61K31/4439

Abstract: Small molecule inhibitors of XBP1 splicing by IRE1α are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

Abstract translation: 提供了通过IRE1α剪接XBP1的小分子抑制剂，以及它们用于治疗或预防癌症（例如内分泌耐药性乳腺癌），糖尿病和肥胖症的方法。