公开(公告)号：US20220324866A1

公开(公告)日：2022-10-13

申请号：US17127297

申请日：2020-12-18

申请人： GILEAD SCIENCES, INC. ,  CARNA BIOSCIENCES, INC.

发明人： Masaaki SAWA ,  Mai ARAI ,  Ryoko NAKAI ,  Hirokazu MATSUMOTO ,  Catherine PUGH ,  Eric HU ,  Juan GUERRERO ,  Jesse JACOBSEN ,  Jonathan William MEDLEY ,  Jie XU ,  Latesh LAD ,  Leena PATEL ,  Michael GRAUPE ,  Qingming ZHU ,  Stephen HOLMBO ,  Tetsuya KOBAYASHI ,  Will WATKINS ,  Yasamin MOAZAMI ,  Suet C. YEUNG ,  Julian A. CODELLI ,  Heath A. WEAVER

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K31/519 ,  A61K31/538 ,  A61K31/55 ,  A61K31/395 ,  A61K31/695 ,  C07F7/18 ,  A61K31/5377 ,  A61K31/553 ,  A61K45/06 ,  A61K39/395 ,  A61K31/704 ,  A61K31/7068 ,  A61K35/17 ,  A61K35/15

摘要： The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.