公开(公告)号：US20250057867A1

公开(公告)日：2025-02-20

申请号：US18589387

申请日：2024-02-27

Applicant: Gilead Sciences, Inc.

Inventor： Bruce S. Ross ,  Michael Joseph Sofia ,  Ganapati Reddy Pamulapati ,  Suguna Rachakonda ,  Hai-Ren Zhang ,  Byoung-Kwon Chun ,  Peiyuan Wang

IPC: A61K31/7072 ,  A61K9/20 ,  A61K45/06 ,  C07F9/24 ,  C07H19/06 ,  C07H19/10 ,  C07H23/00

Abstract: Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.

公开(公告)号：US12227520B2

公开(公告)日：2025-02-18

申请号：US18050650

申请日：2022-10-28

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Ana Z. Gonzalez Buenrostro ,  Hongyan Guo ,  Xiaochun Han ,  Lan Jiang ,  Jiayao Li ,  Michael L. Mitchell ,  Hyung-Jung Pyun ,  Scott D. Schroeder ,  Gregg M. Schwarzwalder ,  Nathan D. Shapiro ,  Devleena M. Shivakumar ,  Qiaoyin Wu ,  Hong Yang ,  Jennifer R. Zhang

IPC: C07D498/18 ,  A61P31/18 ,  C07D471/18

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20250049908A1

公开(公告)日：2025-02-13

申请号：US18743701

申请日：2024-06-14

Applicant: Gilead Sciences, Inc.

Inventor： Jiani Li ,  Xinan Liu ,  Azure T. Makadzange ,  Stephen R. Martin ,  Sarah Schmidt ,  Hesham Shehata ,  Felix Stemeseder ,  Evguenia Svarovskaia ,  Archana V. Boopathy

IPC: A61K39/12 ,  A61K39/00 ,  A61P31/18 ,  C07K14/005 ,  C07K16/10 ,  C07K16/28 ,  C12N15/10 ,  C12N15/86

Abstract: Provided are HIV-1 fusion polypeptides, polynucleotides encoding such fusion polypeptides, vectors expressing such fusion polypeptides for use in eliciting an immune response against HIV-1; pharmaceutical and immunogenic compositions and kits comprising such fusion polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HIV-1. Further provided are methods for design of antiviral vaccines, including vaccines to elicit an immune response against HIV-1.

公开(公告)号：US20250042913A1

公开(公告)日：2025-02-06

申请号：US18596486

申请日：2024-03-05

Applicant: Gilead Sciences, Inc.

Inventor： Michael O'Neil Hanrahan Clarke ,  Richard L. Mackman ,  Dustin Siegel

IPC: C07D495/04 ,  C07D519/00 ,  C07H7/06 ,  C07H11/04

Abstract: Provided herein are formulations, methods and substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds.

公开(公告)号：US20250034186A1

公开(公告)日：2025-01-30

申请号：US18755378

申请日：2024-06-26

Applicant: Gilead Sciences, Inc.

Inventor： Byoung-Kwon Chun ,  Edward Doerffler ,  Dustin S. Siegel ,  Andrew C. Stevens ,  Tiago Vieira

IPC: C07F9/6561 ,  A61P31/14 ,  A61P31/16 ,  C07D487/04

Abstract: The present disclosure provides a compound of Formula I: which is useful in treating a variety of diseases, such as diseases caused by respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, HCV and/or HBV infection

公开(公告)号：US20250034182A1

公开(公告)日：2025-01-30

申请号：US18750925

申请日：2024-06-21

Applicant: Gilead Sciences, Inc.

Inventor： Byoung-Kwon Chun ,  Michael O. Clarke ,  Deeba Ensan ,  Rao V. Kalla ,  Richard L. Mackman ,  Jagadeesh N. Manda ,  Devan Naduthambi ,  Dustin S. Siegel

IPC: C07F9/09 ,  A61P31/14

Abstract: Phospholipid compounds and methods of using the same, singly or in combination with additional agents, and pharmaceutical formulations of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US12202849B2

公开(公告)日：2025-01-21

申请号：US17885883

申请日：2022-08-11

Applicant: Gilead Sciences, Inc.

Inventor： Chiajen Lai ,  Bing Shi ,  Robert G. Strickley

IPC: C07F9/6561 ,  A61K9/00 ,  A61K31/675 ,  A61K45/06

Abstract: The present invention relates to novel crystalline forms of salts and/or co-crystals of tenofovir alafenamide, the pharmaceutical formulations, and the therapeutic uses thereof in treating viral infections.

公开(公告)号：US12202842B2

公开(公告)日：2025-01-21

申请号：US18181116

申请日：2023-03-09

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  David W. Lin ,  Jonathan William Medley ,  Devan Naduthambi ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang ,  Qingming Zhu

IPC: C07D413/08 ,  A61K31/553 ,  A61K45/06 ,  A61P35/00 ,  C07D513/08 ,  C07D513/10 ,  C07D513/18 ,  C07D513/20 ,  C07D513/22 ,  C07D519/00 ,  C07K16/28

Abstract: The present disclosure generally relates to compounds of Formula (1) and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US12187753B2

公开(公告)日：2025-01-07

申请号：US18236532

申请日：2023-08-22

Applicant: Gilead Sciences, Inc.

Inventor： Julie Farand ,  Tezcan Guney ,  Darryl Kato ,  John O. Link ,  James B. C. Mack ,  William J. Watkins

IPC: C07F9/09

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.

公开(公告)号：US20250002471A1

公开(公告)日：2025-01-02

申请号：US18268469

申请日：2021-12-21

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Eda Y. Canales ,  Weng K. Chang ,  Scott E. Lazerwith ,  Daniel G. Shore

IPC: C07D401/14 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/499 ,  A61K31/4995 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/55 ,  A61K31/551 ,  C07D401/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D495/04 ,  C07D498/10

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.