公开(公告)号：US10343971B2

公开(公告)日：2019-07-09

申请号：US16071739

申请日：2017-02-15

Applicant: GIVAUDAN SA

Inventor： Andreas Goeke ,  Felix Flachsmann ,  Dominique Lelievre ,  Andreas Natsch ,  Francis Voirol ,  Yue Zou ,  Thierry Granier

IPC: C07C69/608 ,  C07C229/04 ,  C07C323/52 ,  A61Q13/00 ,  A61K8/37 ,  A61K8/46 ,  C07C69/533 ,  C07C69/56

Abstract: A compound of formula I wherein R1, R2, R3 and R4 can be independently selected from H or Me, n=0, 1, the dotted lines are indicating single bonds, or in case n=0 an isolated double bond at position 3′, or in case n=1 an isolated double bond at position 3′ or 4′, and the wavy bond is indicating an unspecified configuration of the adjacent double bond. Said compounds, as well as precursors capable to generate said compounds, are useful as fragrance ingredients.

公开(公告)号：US10125356B2

公开(公告)日：2018-11-13

申请号：US14796281

申请日：2015-07-10

Applicant: Givaudan SA

Inventor： Andreas Natsch ,  Roger Emter

IPC: C12N9/52 ,  C12Q1/37

Abstract: Provided are methods to identify modulators and in particular inhibitors of body malodor formation employing peptidase enzymes, the peptidase enzymes and corresponding nucleotide sequences, expression vectors, transfected host cells, methods of forming the peptidase enzymes and methods to prevent body malodor.

公开(公告)号：US20160046921A1

公开(公告)日：2016-02-18

申请号：US14796281

申请日：2015-07-10

Applicant: Givaudan SA

Inventor： Andreas Natsch ,  Roger Emter

IPC: C12N9/52

CPC classification number: C12N9/52 ,  C12Q1/37 ,  G01N2500/02 ,  G01N2800/00

Abstract: Provided are methods to identify modulators and in particular inhibitors of body malodour formation employing peptidase enzymes, the peptidase enzymes and corresponding nucleotide sequences, expression vectors, transfected host cells, methods of forming the peptidase enzymes and methods to prevent body malodour.

Abstract translation: 提供了鉴定调节剂的方法，特别是使用肽酶，肽酶和相应的核苷酸序列，表达载体，转染的宿主细胞，形成肽酶的方法和预防身体恶臭的方法来鉴定身体恶臭形成的抑制剂。

公开(公告)号：US10512599B2

公开(公告)日：2019-12-24

申请号：US15235587

申请日：2016-08-12

Applicant: Givaudan SA

Inventor： Andreas Natsch ,  Michael Wasescha

IPC: A61K8/40 ,  A61K8/33 ,  A61K8/37 ,  A61K8/35 ,  A61K8/368 ,  A61K31/275 ,  A61K31/05 ,  A61K8/34 ,  A61Q13/00 ,  A61Q15/00 ,  A61Q19/00

Abstract: The invention relates to organic compounds having the ability to reduce or suppress the onset of skin irritation induced by extraneous cause selected from the group of 2-heptylcyclopentanone, 2-ethoxynaphthalene; 2-methoxynaphthalene; 1-methoxy-4-(prop-1-enyl)benzene; 1-(cyclopropylmethyl)-4-methoxybenzene; wherein X, Y, and R1 to R11 have the same meaning as given in the description. Furthermore the invention refers to compositions for topical application to the skin comprising them. It further relates to a method of reducing or suppressing the formation of skin irritation.