公开(公告)号：US20230021613A1

公开(公告)日：2023-01-26

申请号：US17776686

申请日：2020-12-03

Applicant: Givaudan SA

Inventor： Eric EICHHORN ,  Christophe ULLMANN

IPC: C12P17/02 ,  C12N9/90

Abstract: Squalene Hopene Cyclase (SHC) enzymes and variants thereof and their uses for making (−)-Ambrox from homofarnesol and Ambra oxide from bishomofarnesol.

公开(公告)号：US20250027126A1

公开(公告)日：2025-01-23

申请号：US18703116

申请日：2022-10-20

Applicant: GIVAUDAN SA

Inventor： Eric EICHHORN ,  Alessandro SCARDUA ,  Christophe ULLMANN

IPC: C12P17/08 ,  A61K8/49 ,  A61Q13/00 ,  C07D313/20 ,  C07D493/08 ,  C12N9/90

Abstract: Improved methods of making amberketal and amberketal homologues and compositions comprising same, improved squalene-hopene cyclase (SHC) enzymes to be used in said methods, nucleic acid constructs and vectors encoding said enzymes, and host cells expressing said enzymes.