公开(公告)号：US20230357809A1

公开(公告)日：2023-11-09

申请号：US18322167

申请日：2023-05-23

Applicant: Givaudan SA

Inventor： Ghislain SANHAJI ,  Alix ROUSSEAUX ,  Sandrine NOEL ,  Eric EICHHORN

IPC: C12P17/04 ,  C07D307/92 ,  A61Q13/00

CPC classification number: C12P17/04 ,  C07D307/92 ,  A61Q13/00 ,  C07B2200/07 ,  C07B2200/13 ,  C12Y504/99017

Abstract: A solid form of (−)-Ambrox formed by a bioconversion process.

公开(公告)号：US20180148751A1

公开(公告)日：2018-05-31

申请号：US15568945

申请日：2016-04-22

Applicant: Givaudan SA

Inventor： Eric EICHHORN ,  Boris SCHILLING ,  Denis WAHLER ,  Laurent FOURAGE ,  Esther LOCHER

IPC: C12P17/04 ,  C07D307/92 ,  C12N9/90

CPC classification number: C12P17/04 ,  C07D307/92 ,  C12N9/90

Abstract: There is provided SHC/HAC derivatives, amino acid sequences comprising the SHC/HAC derivatives, nucleotide sequences encoding the SHC/HAC derivatives, vectors comprising nucleotide sequences encoding the SHC/HAC derivatives, recombinant host cells comprising nucleotide sequences encoding the SHC/HAC derivatives and applications of the recombinant host cells comprising either SHC/HAC derivatives or WT SHC/HAC enzymes in methods to prepare (−)-Ambrox and SHC/HAC enzymes in methods to prepare (−)-Ambrox.

公开(公告)号：US20250027126A1

公开(公告)日：2025-01-23

申请号：US18703116

申请日：2022-10-20

Applicant: GIVAUDAN SA

Inventor： Eric EICHHORN ,  Alessandro SCARDUA ,  Christophe ULLMANN

IPC: C12P17/08 ,  A61K8/49 ,  A61Q13/00 ,  C07D313/20 ,  C07D493/08 ,  C12N9/90

Abstract: Improved methods of making amberketal and amberketal homologues and compositions comprising same, improved squalene-hopene cyclase (SHC) enzymes to be used in said methods, nucleic acid constructs and vectors encoding said enzymes, and host cells expressing said enzymes.

公开(公告)号：US20230203548A1

公开(公告)日：2023-06-29

申请号：US17998540

申请日：2021-06-30

Applicant: Givaudan SA

Inventor： Eric EICHHORN ,  Andreas GOEKE

IPC: C12P7/54 ,  C12N9/02 ,  C12P7/04

CPC classification number: C12P7/54 ,  C12N9/0073 ,  C12P7/04

Abstract: An enzyme-mediated method for the production of acetates as defined by formula (I), the products of said method, and uses of said products.

公开(公告)号：US20210254112A1

公开(公告)日：2021-08-19

申请号：US17240262

申请日：2021-04-26

Applicant: Givaudan SA

Inventor： Eric EICHHORN ,  Boris SCHILLING ,  Denis WAHLER ,  Laurent FOURAGE ,  Esther LOCHER

IPC: C12P17/04 ,  C12N9/90 ,  C07D307/92

Abstract: There is provided SHC/HAC derivatives, amino acid sequences comprising the SHC/HAC derivatives, nucleotide sequences encoding the SHC/HAC derivatives, vectors comprising nucleotide sequences encoding the SHC/HAC derivatives, recombinant host cells comprising nucleotide sequences encoding the SHC/HAC derivatives and applications of the recombinant host cells comprising either SHC/HAC derivatives or WT SHC/HAC enzymes in methods to prepare (−)-Ambrox and SHC/HAC enzymes in methods to prepare (−)-Ambrox.

公开(公告)号：US20240401094A1

公开(公告)日：2024-12-05

申请号：US18797477

申请日：2024-08-07

Applicant: Givaudan SA

Inventor： Ghislain SANHAJI ,  Alix ROUSSEAUX ,  Sandrine NOEL ,  Eric EICHHORN

IPC: C12P17/04 ,  A61Q13/00 ,  C07D307/92

Abstract: A solid form of (−)-Ambrox formed by a bioconversion process.

公开(公告)号：US20230021613A1

公开(公告)日：2023-01-26

申请号：US17776686

申请日：2020-12-03

Applicant: Givaudan SA

Inventor： Eric EICHHORN ,  Christophe ULLMANN

IPC: C12P17/02 ,  C12N9/90

Abstract: Squalene Hopene Cyclase (SHC) enzymes and variants thereof and their uses for making (−)-Ambrox from homofarnesol and Ambra oxide from bishomofarnesol.

公开(公告)号：US20230009254A1

公开(公告)日：2023-01-12

申请号：US17777336

申请日：2020-12-03

Applicant: Givaudan SA

Inventor： Eric EICHHORN ,  Felix FLACHSMANN

IPC: C12P17/04 ,  C07C33/02 ,  C07D307/92

Abstract: An enzyme-mediated method for the production of 3a-ethyl-6,6,9a-trimethyldodecahydronaphtho[2,1-b]furan, the products of said method, and uses of said products.

公开(公告)号：US20180134678A1

公开(公告)日：2018-05-17

申请号：US15568535

申请日：2016-04-22

Applicant: Givaudan SA

Inventor： Eric EICHHORN

IPC: C07D307/92 ,  C07B63/00 ,  B01D9/00 ,  C11B9/00 ,  C12P17/04

CPC classification number: C07D307/92 ,  B01D9/005 ,  C07B63/00 ,  C07B2200/09 ,  C11B9/0076 ,  C12P17/04 ,  C12Y504/99017

Abstract: A method of isolating and purifying (−)-Ambrox from a reaction mixture comprising (−)-Ambrox and one or more of the compounds (II), (III) and (IV)

公开(公告)号：US20240417409A1

公开(公告)日：2024-12-19

申请号：US18701983

申请日：2022-10-20

Applicant: GIVAUDAN SA

Inventor： Eric EICHHORN ,  Thierry GRANIER

IPC: C07D493/08 ,  A61K8/49 ,  A61Q15/00

Abstract: The disclosure relates to sesquiterpene homologues, their use as fragrance and a method of their production.